A5066108764- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Neuroblastoma Research and Treatments
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Parathyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- BRCA gene mutations in cancer
- Intestinal and Peritoneal Adhesions
- Body Contouring and Surgery
- Hernia repair and management
- Pain Management and Opioid Use
- Biomarkers in Disease Mechanisms
- Cancer Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Child and Adolescent Psychosocial and Emotional Development
- Surgical Simulation and Training
- Genetic factors in colorectal cancer
- Venous Thromboembolism Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Intestinal Malrotation and Obstruction Disorders
- Head and Neck Anomalies
University of Chicago
2023-2024
Yale University
2018-2023
American University of Beirut
2017
American University of Beirut Medical Center
2017
Abstract Context Medullary thyroid cancer (MTC) has a historic recurrence rate up to 50%, and surgery remains the only cure. Objective This study aims assess factors related metastatic spread in MTC. Methods Retrospective chart review was performed from 1990 2023 at single specialized tertiary care referral center. Descriptive analysis regression models were used for analysis. Sixty-eight patients with MTC, who underwent surgery, included main outcome measure recurrence. Results Mean age...
Foci of papillary or follicular thyroid carcinoma are frequently noted in thyroidectomy specimens anaplastic (ATC). However, whether ATCs evolve from these co-existing well-differentiated carcinomas (WDTCs) has not been well-understood. To investigate the progression ATC patients with WDTCs, five tumors WDTCs and matching normal tissues were whole-exome sequenced. After mapping somatic alteration landscape, evolutionary lineages constructed by sub-clone analysis. Though each tumor harbored...
This study aims to quantitatively assess use of the NSQIP surgical risk calculator (NSRC) in contemporary practice and identify barriers potential interventions that might increase use. We performed a cross-sectional surgeons at seven institutions. The primary outcomes were self-reported application general clinical specific scenarios as well reported In our sample 99 (49.7% response rate), 73.7% NSRC past month. Approximately half (51.9%) respondents infrequent (<20% preoperative...
Background: Peptide Receptor Radionuclide Therapy (PRRT), a form of Radioligand (RLT), and Capecitabine/Temozolomide (CAPTEM) are cornerstones systemic therapy for metastatic pancreatic neuroendocrine tumors (PNETs). Data regarding comparative efficacy lacking. Herein, we compare the PRRT vs. CAPTEM as second-line/beyond regimens treatment sequencing. Methods: Clinicopathologic, radiographic, genomic data were captured PNETs seen in our multi-disciplinary NET clinic between 2013 2023. The...
Bezoar-induced small bowel obstruction is a rare entity. It should be highly suspected in patients with gastric hypomotility disorders, psychiatric conditions, prior abdominal or bariatric surgery, improper intake of medication. Their diagnosis quite challenging and surgical exploration remains the best treatment choice to ensure viability tissue relieve obstruction. This case 48-year-old female no previous surgery who presented acute pain. The patient's history was remarkable for daily...
Abstract Background: Peptide Receptor Radionuclide Therapy (PRRT) using 177Lu-DOTATATE is an effective treatment for metastatic Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs). However, it remains unknown why some patients (pts) respond more favorably than others. Pre-clinical data suggests that mutations in the MEN1, DAXX, and/or ATRX genes influence DNA repair capabilities and increase radiation effect cancer cells. We therefore thought to evaluate association between response PRRT...
Pre-clinical data suggest that mutations in the MEN1 , DAXX and/or ATRX genes may potentially increase radiation efficacy cancer cells. Herein, we explore association between response to peptide receptor radionuclide therapy (PRRT) and those patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We analyzed tissue-based next generation sequencing (NGS) assay results clinicopathologic from 28 GEP-NETs treated PRRT. Findings were correlated progression-free survival (PFS)...
Purpose: Society tends to accord greater importance biological illnesses, in comparison mental disorders. In Lebanon, a gap was observed the knowledge, attitude and practice (KAP) towards We aimed assess KAP regarding illnesses among university students compare their outlook based on socio-demographic characteristics, educational factors previous exposure Methods: A cross-sectional study conducted Lebanese students. questionnaire filled by 598 were assessed separate sets of questions for two...