A5079485527- Lung Cancer Diagnosis and Treatment
- Diversity and Career in Medicine
- Gastric Cancer Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Economic and Financial Impacts of Cancer
- Bariatric Surgery and Outcomes
- Global Cancer Incidence and Screening
- Surgical Simulation and Training
- Esophageal Cancer Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Thyroid and Parathyroid Surgery
- Dysphagia Assessment and Management
- Nausea and vomiting management
- Global Health Care Issues
- COVID-19 and healthcare impacts
- Cancer survivorship and care
- Health and Conflict Studies
- Cardiac Arrest and Resuscitation
- Spinal Cord Injury Research
- Hospital Admissions and Outcomes
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
Yale University
2019-2024
Yale Cancer Center
2021-2024
Yale New Haven Hospital
2023
Cancer Research Institute
2018
University of Pennsylvania
2015-2018
Penn Center for AIDS Research
2016
University of Pennsylvania Health System
2016
University of Maryland, Baltimore County
2011
The role of metal ions in Alzheimer's disease etiology is unresolved. For the redox-active iron and copper, formation reactive oxygen species by amyloid complexes has been proposed to contribute neurodegeneration. are generated copper redox cycling between its 1+ 2+ oxidation states. Thus, AβCuI complex potentially a critical reactant associated with etiology. Through competitive chelation, we have measured affinity soluble copper-binding domain amyloid-β peptide for CuI. dissociation...
Clinical trials and compassionate use agreements provide selected patients with access to potentially life-saving treatments before approval by the Food Drug Administration (FDA). Approval from FDA decreases a number of barriers; however, it is unknown whether associated increases in equitable novel therapies reductions disparities among cancer US.
Abstract Background Palliative treatment has been associated with improved quality of life and survival for a wide variety metastatic cancers. However, it is unclear whether the benefits palliative are uniformly experienced across US cancer population. We evaluated patterns outcomes based on socioeconomic, sociodemographic treating facility characteristics. Methods Patients diagnosed between 2008 2019 Stage IV primary nine organ sites were analyzed in National Cancer Database. The...
Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among most common gastrointestinal disorders. Inflamed tissues frequently experience conditions insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia consequent stabilization hypoxia-inducible factor 1α (HIF1α) transcription occur in murine human pancreatitis. Mice lacking pancreas-specific HIF1α expression display markedly impaired pancreatic regeneration following cerulein-induced...
Donation after cardiac death (DCD) liver transplantation is associated with increased biliary complications and graft failure. Yet for unclear reasons, DCD recipients relisted have lower wait-list mortality than other retransplant candidates. We used Organ Procurement Transplantation Network United Sharing data from 2002 to 2011 evaluate all the impact of utilization Model End-Stage Liver Disease (MELD) exception points on outcomes. Of 262 >2 weeks initial transplantation, 82 (31.3%) applied...
<h3>Importance</h3> The 2017 international PACIFIC trial established a role for immunotherapy after chemoradiation unresectable stage III non–small cell lung cancer (NSCLC). However, in the US, patients with NSCLC commonly differ from clinical populations terms of age, health, access to care, and treatment course, which may all factor into efficacy immunotherapy. <h3>Objective</h3> To determine outcomes use general US population. <h3>Design, Setting, Participants</h3> This cohort study...
Available guidelines are inconsistent as to whether patients with newly diagnosed clinical stage II NSCLC should receive routine brain imaging.
For patients with stage IV esophageal cancer, radiation may be used selectively for local control and palliation. We aimed to understand patterns of administration among cancer any potential survival associations.
This cohort study examines the association of insurance status and extent metastatic organ involvement with survival among patients stage IV cancer to better understand outcome disparities in US.
This cohort study examines baseline differences in cancer mortality between Medicaid expansion and nonexpansion states.