A5086467249- Thyroid Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Genetic Syndromes and Imprinting
- Cancer, Hypoxia, and Metabolism
- Sympathectomy and Hyperhidrosis Treatments
- Medical Imaging and Pathology Studies
- Bone health and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Enhanced Recovery After Surgery
- S100 Proteins and Annexins
- Head and Neck Anomalies
- Appendicitis Diagnosis and Management
- interferon and immune responses
- Genetic factors in colorectal cancer
- Frailty in Older Adults
- Aortic aneurysm repair treatments
- Nausea and vomiting management
- Intestinal Malrotation and Obstruction Disorders
- Congenital heart defects research
- Pancreatic and Hepatic Oncology Research
Yale University
2017-2024
University of New Haven
2024
VA Connecticut Healthcare System
2023
Yale New Haven Health System
2023
Yale New Haven Hospital
2019-2023
Abstract Differentiation of pluripotent stem cells into functional parathyroid-like would accelerate development important therapeutic options for subjects with parathyroid-related disorders, from the design and screening novel pharmaceutical agents to durable cellular therapies. We have established a highly reproducible directed differentiation approach leading PTH-expressing human embryonic induced cells. accomplished this through comparison multiple different basal media, inclusion CDK...
Objective We aimed to evaluate trends and outcomes of surgical approaches thyroid surgery. hypothesized that there have been changes over time in the utilization thyroidectomy, including endoscopic, robotic, open approaches, patient may differ between surgery endoscopic or robotic approaches. Study Design Retrospective analysis. Setting The National Cancer Database (NCDB) was queried 2010 2016. Subjects Methods cohort patients. Descriptive statistics were performed using χ 2 test,...
Abstract INTRODUCTION: Treatment emergent adverse events (TEAEs) thyroiditis/thyrotoxicosis and hypothyroidism occur in up to 40% of patients treated with immune checkpoint inhibitors (ICIs). Conventional autoimmune thyroiditis autoantibodies (AutoAbs) (thyroglobulin (TG); thyroid peroxidase (TPO)) do not predict these TEAEs. We previously reported that pretreatment serum AutoAb profiles were associated all severe TEAEs for melanoma ICIs. Herein, we test if pre-existing AutoAbs could ICI...
Studies on human parathyroids are generally limited to hyperfunctioning glands owing the difficulty in obtaining normal tissue. We therefore obtained non-human primate (NHP) provide a suitable alternative for sequencing that would bear close semblance organs. Single-cell RNA expression analysis of from four healthy adult
Abstract Disclosure: P. Balasubramanian: None. A. Ladenheim: S. Gilani: C. Gibson: Kunz: Introduction: Papillary thyroid carcinoma is the most common differentiated carcinoma. Thyroid metastasis from neuroendocrine tumors (NETs) extremely rare with an estimated prevalence of <1%. We report a case 59 year old female co-existence papillary and intrathyroidal lung NET. Case: A 59-year-old metastatic, well-differentiated NET (Ki-67 15%, unable to distinguish between typical atypical) was...
e18110 Background: Hürthle cell carcinoma is a rare type of thyroid cancer. We report the results tumor profiling from patients seen at Yale Cancer Center / Smilow Hospital including with microsatellite instability (MSI) and somatic MSH2 mutation. Methods: 5 metastatic carcinomas were identified between 2014-2017. Tumor was performed by targeted DNA sequencing assays (Oncomine Comprehensive Assay Yale-New Haven Profiling Laboratory, FoundationOne Foundation Medicine, or MSK-IMPACT Memorial...
Abstract Tumorigenesis requires mitigation of osmotic stress and the transcription factor nuclear activated T cells 5 (NFAT5) coordinates this response by inducing transcellular transport ions osmolytes. NFAT5 modulates in vitro behavior several cancer types, but a potential role adrenocortical carcinoma (ACC) has not been studied. A discovery cohort 28 ACCs was selected for analysis. Coverage depth analysis whole-exome sequencing reads assessed copy number alterations 19 ACCs. Quantitative...
Neck ultrasonography with fine-needle aspiration cytology (FNAC) is the diagnostic modality of choice for clinicians who routinely work up a thyroid mass. Distinguishing chronic lymphocytic infiltration from lymphoproliferative process FNAC in patients Hashimoto's thyroiditis presenting goiter can be particularly challenging. A 58 y.o. female history showing interval growth and compressive symptoms over 18 months, was treated lobectomy. Surgical pathology demonstrated lymphoma (TL) mixed...
Objective: Stroke is a rare presenting symptom of pheochromocytoma; therefore, balance between adequate pre-operative medical blockade and expedition surgery to minimize the risk further peri-operative stroke needed. However, currently there are no established guidelines regarding timing or length in these patients. We report case pheochromocytoma 53-year-old woman with hemorrhagic transformation an ischemic stroke. describe clinical course, diagnosis, management our then discuss similar...
Objective: Of the 37 million Americans who have diabetes, up to 25% experience painful diabetic neuropathy (PDN).While conventional medical management (CMM), which includes pharmacotherapies, can be ineffective for many patients, high-frequency (10 kHz) spinal cord stimulation (SCS) has been shown provide substantial symptom relief PDN.Here we report durability of outcomes 24 months (24M) 10 kHz SCS treatment PDN.Methods: We conducted a prospective, multicenter, randomized, controlled trial...