A5045630692- AI in cancer detection
- Cell Image Analysis Techniques
- Pancreatic and Hepatic Oncology Research
- Epigenetics and DNA Methylation
- Thyroid Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Neonatal Respiratory Health Research
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Neurogenesis and neuroplasticity mechanisms
- BRCA gene mutations in cancer
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Neuroscience of respiration and sleep
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Reproductive tract infections research
- Genomics and Chromatin Dynamics
- Gastrointestinal disorders and treatments
- Head and Neck Cancer Studies
- Brain Metastases and Treatment
- CAR-T cell therapy research
- Medical Image Segmentation Techniques
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
Weill Cornell Medicine
2022-2024
Presbyterian Hospital
2021-2024
Cornell University
2021-2024
New York Hospital Queens
2021-2024
NewYork–Presbyterian Hospital
2021-2024
The Ohio State University
2013-2024
University Hospitals of Cleveland
2019-2020
Case Western Reserve University
2018-2020
University School
2019-2020
Bellingham Technical College
2016
Human congenital central hypoventilation syndrome (CCHS), resulting from mutations in transcription factor PHOX2B, manifests with impaired responses to hypoxemia and hypercapnia especially during sleep. To identify brainstem structures developmentally affected CCHS, we analyzed two postmortem neonatal-lethal cases confirmed polyalanine repeat expansion (PARM) or Non-PARM (PHOX2B∆8) mutation of PHOX2B. Both human showed neuronal losses within the locus coeruleus (LC), which is important for...
Objectives/Hypothesis To determine speech, eating, aesthetics, social disruption, and overall quality-of-life outcomes over a year period in patients who underwent transoral robotic surgery as part of carcinoma unknown primary diagnosis treatment. Study Design Observational prospective study. Methods Twenty-two for the management were included. Patients prospectively completed Head Neck Cancer Inventory during preoperative visit, at 3-week, 3-month, 6-month, 12-month postoperative visits....
Keratocystic odontogenic tumors (KCOTs) are locally aggressive neoplasms with recurrence rates of up to 60%. Approximately 5% KCOTs associated nevoid basal cell carcinoma (Gorlin) syndrome and 90% these show genomic inactivation the PTCH1 gene encoding Patched 1. Sporadic reportedly have mutations in 30% cases, but previous analyses been limited by low tumor DNA yield. The aim this study was identify recurrent aberrations sporadic using a next-generation sequencing panel complete exonic...
Transoral robotic surgery (TORS) has emerged as a novel, safe, and feasible procedure for the resection of supraglottic laryngeal cancers. The purpose this study was to demonstrate surgical technique TORS laryngectomy (SGL).A patient with T2N0M0 cancer limited larynx selected TORS.En bloc tumor accomplished negative margins together bilateral selective neck dissection. There no perioperative or early postoperative complication. extubated immediately after surgery. Oral diet initiated within...
Abstract Introduction The International System for Reporting Serous Fluid Cytopathology proposed five diagnostic categories: Nondiagnostic (ND), Negative Malignancy (NFM), Atypia of Undetermined Significance (AUS), Suspicious (SFM) and Malignant (MAL) (Primary or Metastatic). indeterminate (AUS/SFM) categories are challenging management. goal this study is to reveal the root causes contributing diagnoses (ID). Materials Methods We searched our archives between 1 January 2017 30 June 2019,...
Molecular testing (MT) of thyroid fine-needle aspiration (FNA)-derived genetic material is commonly used to assess malignancy risk for indeterminate cases. The Bethesda System Reporting Thyroid Cytopathology (TBS) provides limited guidance the appropriate use category III (atypia undetermined significance [AUS]). authors combined MT with cytomorphology monitor AUS diagnoses in a cytopathology laboratory.Neoplasia-associated alterations (NGAs) were determined by preoperative FNA biopsies or...
Abstract Objectives Afirma has recently introduced its Xpression Atlas (XA) as an adjunct to Genomic Sequencing Classifier (GSC) for risk stratification of cytologically indeterminate thyroid nodules. We evaluated the performance XA and associated pathologic findings GSC suspicious Methods Intradepartmental records fine-needle aspirations (FNAs) from January 2021 December 2022 were identified reviewed patient nodule characteristics, FNA findings, molecular test results, final surgical...
Human papillomavirus (HPV) is known to be associated with squamous intraepithelial lesions (SILs). However, there limited and conflicting literature on the relationship between bacterial vaginosis (BV) SIL. The aim of this study determine prevalence BV evaluate association SIL.A retrospective was performed 10,546 cases 2012 2017. HPV results were available in 7,081 cases.BV present 17.6% cases. There significant BV, positive infection, high-grade patients negative infection showed more...
Late embryonic and postnatal cerebellar folial surface area expansion promotes cortical cytoarchitectural lamination. We developed a streamlined sampling scheme to generate unbiased estimates of murine volume using stereologic principles. demonstrate that, during the proliferative phase external granular layer (EGL) expansion, EGL thickness does not change thus is topological proxy for progenitor self-renewal. The constraints indicate phases, migration out balanced by Progenitor self-renewal...
ABSTRACT The postnatal period in mammals represents a developmental epoch of significant change the autonomic nervous system (ANS). This study focuses on development area postrema, crucial ANS structure that regulates temperature, breathing, and satiety, among other activities. We find human postrema undergoes changes during development. To characterize these further, we used transgenic mouse reagents to delineate neuronal circuitry. discovered that, although well‐formed scaffold exists...
Abstract Background Per the College of American Pathologist’s National Breast Fine Needle Aspiration Biopsy (FNAB) Practice Survey, ∼40% laboratories use liquid‐based cytology (LBC) for breast FNAB. The reproducibility International Academy Cytology Yokohama System (YS) reporting FNAB on LBC was explored. Design specimens submitted as only (all ThinPrep) between January 2017 and 2021 were retrieved. Cases without histopathologic follow‐up excluded. Clinical radiologic information collected....
Few cytologically indeterminate thyroid fine-needle aspirations (FNAs) harbor BRAF V600E. Here, we assess interobserver agreement for The Bethesda System Reporting Thyroid Cytopathology (TBSRTC) category III (atypia of undetermined significance [AUS]) FNAs harboring V600E and contrast their features with those non-BRAF alterations, attention to cytopathology experience.
Intraoperative neuropathology of glioma recurrence represents significant visual challenges to pathologists as they carry clinical implications. For example, rendering a diagnosis recurrent can help the surgeon decide perform more aggressive resection if surgically appropriate. In addition, success recent trials for intraoperative administration therapies, such inoculation with oncolytic viruses, may suggest that refinement during neurosurgery is an emerging need pathologists. Typically,...
Aging | doi:10.18632/aging.100990. Patrick E. Gygli, Joshua C. Chang, Hamza N. Gokozan, Fay P. Catacutan, Theresa A. Schmidt, Behiye Kaya, Mustafa Goksel, Faisal S. Baig, Shannon Chen, Amelie Griveau, Wojciech Michowski, Michael Wong, Kamalakannan Palanichamy, Piotr Sicinski, Randy J. Nelson, Catherine Czeisler, José Otero
Abstract BACKGROUND Molecular testing is an essential step in providing patients with advanced non‐small‐cell lung cancer (NSCLC), the most appropriate front‐line targeted therapies. We recently implemented NGS on previously discarded cytology centrifuged supernatant (CCS). METHODS In this study, we reviewed our implementation process to evaluate its performance. Performance and turnaround time (TAT) of molecular all NSCLC cases submitted for from June 2018 September 2019 were evaluated,...
Abstract Patient derived tumor organoids (PDTOs) have become relevant pre-clinical models for therapeutic modelling since they highly recapitulate patients’ response to treatment. Nevertheless, their value immunotherapy has not been fully explored. We developed a processing protocol that enable the establishment of PDTOs and infiltrating lymphocytes (TILs) isolation. By optimization functional assays, we compared T-cells effector functions matching PBMCs TILs, demonstrating after co-culture...