A5004036489- Dermatological and Skeletal Disorders
- Bone Metabolism and Diseases
- Mast cells and histamine
- Cellular Mechanics and Interactions
- Connective tissue disorders research
- Dermatology and Skin Diseases
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Genetic factors in colorectal cancer
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Polyamine Metabolism and Applications
- Ocular Surface and Contact Lens
- Biomedical Research and Pathophysiology
- Wound Healing and Treatments
- Hippo pathway signaling and YAP/TAZ
Manchester Academic Health Science Centre
2021-2025
University of Manchester
2021-2025
Agency for Science, Technology and Research
2025
University of L'Aquila
2020
Abstract Background and objectives Arginase1 (ARG1) is an enzyme expressed by keratinocytes that drives several functions linked to skin barrier function. However, the mechanisms underpinning keratinocyte ARG1 function in homeostasis not fully elucidated. Atopic dermatitis (AD) impaired via altered differentiation susceptibility infection. Therefore, we investigated role of anti-microbial responses. Methods In vitro 2D assays using ARG knockdown or inhibited were used explore formation. was...
Wound infection is a major disruptor of wound healing. Keratinocytes, critical in repair and microbial responses, require the L-arginine hydrolysing enzyme arginase1, for effective pathogens such as Pseudomonas aeruginosa may also need L-arginine. We therefore investigated host-microbial interactions context healing metabolism. Arginase-inhibited murine wounds challenged with P. exhibited significantly delayed re-epithelialisation. This finding was recapitulated vitro using aeruginosa-...