A5072197067- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Bone fractures and treatments
- Elbow and Forearm Trauma Treatment
- Sports injuries and prevention
- Muscle metabolism and nutrition
- Surgical Sutures and Adhesives
- Spaceflight effects on biology
- Esophageal Cancer Research and Treatment
- Organ and Tissue Transplantation Research
- Electrospun Nanofibers in Biomedical Applications
- Anatomy and Medical Technology
- Diabetic Foot Ulcer Assessment and Management
- 3D Printing in Biomedical Research
- Biomedical Ethics and Regulation
- Peripheral Nerve Disorders
- Gastric Cancer Management and Outcomes
- Nerve Injury and Rehabilitation
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Tissue Engineering and Regenerative Medicine
- Angiogenesis and VEGF in Cancer
University of Manchester
2016-2025
Wythenshawe Hospital
2009-2025
Manchester University NHS Foundation Trust
2017-2025
Manchester Academic Health Science Centre
2017-2025
Henry Royce Institute
2016-2024
Manchester University
2023-2024
Sheffield Teaching Hospitals NHS Foundation Trust
2024
National Health Service
2024
Wellcome Centre for Cell-Matrix Research
2023
Kwong Wah Hospital
2021-2023
Purpose To study the effects of early weightbearing and ankle mobilization after acute repair ruptured Achilles tendon. Study Design Comparative longitudinal study. Methods Patients in group 1 were postoperatively immobilized with their gravity equinus, they encouraged to bear weight on operated limb as soon possible full weightbearing, received a single cast change at 2 weeks, accommodated an anterior splint plantigrade position, allowing be plantar flexed fully but not dorsiflexed above...
Peripheral nerve injury (PNI) is a significant health problem that confers lifelong impact on those injured. Current interventions are purely surgical; however, outcomes remain poor. There lack of high-quality epidemiological data needed to identify populations involved, current healthcare demands, and ensure resources distributed the greatest effect, reduce burden.Anonymized hospital episode statistical (HES) admitted patient care was obtained from NHS Digital for all National Health...
The ability of tendons to glide smoothly during muscle contraction is impaired after injury by fibrous adhesions that form between the damaged tendon surface and surrounding tissues. To understand how we incubated excised in fibrin gels (to mimic homeostatic environment at site) assessed cell migration. We noticed cells exiting from only cut ends. Furthermore, treatment with trypsin resulted extravagation shaft tendons. Electron microscopy immunolocalisation studies showed are covered a...
Vascular smooth muscle turnover has important implications for blood vessel repair and the development of cardiovascular diseases, yet lack specific transgenic animal models prevented it's in vivo analysis.The objective this study was to characterize dynamics mechanisms vascular from earliest stages embryonic arterial adult.We show that CD146 is transiently expressed development. By using CRISPR-Cas9 genome editing vitro differentiation assay, we demonstrate regulates balance between...
Surgical robots have the potential to provide surgeons with increased capabilities, such as removing physiologic tremor, scaling motion and increasing manual dexterity. Several surgical specialties subsequently integrated robotic surgery into common clinical practice. Plastic reconstructive microsurgical procedures not yet benefitted significantly from technical developments observed within last two decades. studies successfully demonstrated feasibility of utilising in plastic procedures,...
The repair of tendon injuries is often compromised by post-operative peritendinous adhesions. Placing a physical barrier at the interface between and surrounding tissue could potentially solve this problem reducing adhesion formation. At present, no such system available for routine use in clinical practice. Here, we propose development bilayer membrane combining nanofibrous poly(ε-caprolactone) (PCL) electrospun mesh with layer self-assembling peptide hydrogel (SAPH) laden type-B...
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required functional endocytic system recycles assemble new fibrils. Endogenous collagen production was not for if exogenous available, but the circadian-regulated vacuolar protein sorting (VPS) 33b collagen-binding integrin α11 subunit were fibrillogenesis. Cells lacking VPS33B secrete soluble protomers deficient in...
Abstract Background and objectives Arginase1 (ARG1) is an enzyme expressed by keratinocytes that drives several functions linked to skin barrier function. However, the mechanisms underpinning keratinocyte ARG1 function in homeostasis not fully elucidated. Atopic dermatitis (AD) impaired via altered differentiation susceptibility infection. Therefore, we investigated role of anti-microbial responses. Methods In vitro 2D assays using ARG knockdown or inhibited were used explore formation. was...
Introduction The financial burden of wounds to healthcare systems continues increase, with little progression on advanced treatment options. Single cell RNA sequencing studies have predominantly focused phenotypically different types and are generally descriptive in their analyses. Coordination within the transcriptome can be modelled using hypergraphs, which quantify higher order interactions (coordination between two or more genes) transcriptomic data. Hypergraph modelling analysis entropy...
Purpose To assess the long-term ultrasonographic appearance of rupture Achilles tendon. Subjects and Methods We examined 70 patients at an average 63 months (range 10–120 months) after assessed patient's contralateral tendon also performed ultrasonography on age- sex-matched controls. recorded maximum transverse anteroposterior diameter, presence intratendinous alterations, calcification. Results The diameter ruptured was 11.7 mm (SD = 2.10). patients' normal tendons measured 5.4 0.9), there...