A5071510617- Orthopedic Surgery and Rehabilitation
- Tendon Structure and Treatment
- Bone Tissue Engineering Materials
- Endodontics and Root Canal Treatments
- Electrospun Nanofibers in Biomedical Applications
- Musculoskeletal pain and rehabilitation
- Nerve Injury and Rehabilitation
- Spine and Intervertebral Disc Pathology
- Supramolecular Self-Assembly in Materials
- Dental materials and restorations
- Wound Healing and Treatments
- Sports injuries and prevention
- Surgical Sutures and Adhesives
- Elbow and Forearm Trauma Treatment
- Proteoglycans and glycosaminoglycans research
- Erythrocyte Function and Pathophysiology
- Orthopedic Infections and Treatments
- Pancreatic function and diabetes
- Shoulder Injury and Treatment
- Biomarkers in Disease Mechanisms
- biodegradable polymer synthesis and properties
- Connective tissue disorders research
- Dental Radiography and Imaging
- Tissue Engineering and Regenerative Medicine
- Nanoparticles: synthesis and applications
Henry Royce Institute
2019-2023
University of Manchester
2016-2023
Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, progressive loss of height. Early treatment IVD critical reduction low back pain related disability. As such, minimally invasive therapeutic approaches can halt reverse NP at early stages disease are needed. Recently, we developed an injectable graphene oxide (GO) - self-assembling peptide FEFKFEFK (F: phenylalanine; K:...
The repair of tendon injuries is often compromised by post-operative peritendinous adhesions. Placing a physical barrier at the interface between and surrounding tissue could potentially solve this problem reducing adhesion formation. At present, no such system available for routine use in clinical practice. Here, we propose development bilayer membrane combining nanofibrous poly(ε-caprolactone) (PCL) electrospun mesh with layer self-assembling peptide hydrogel (SAPH) laden type-B...
Antimicrobial silver nanoparticle coatings have attracted interest for reducing prosthetic joint infection. However, few studies report in vivo investigations of the biotransformation nanoparticles within regenerating tissue and its impact on bone formation. We present a longitudinal investigation osseointegration nanoparticle-coated additive manufactured titanium implants rat tibial defects. Correlative imaging at different time points using nanoscale secondary ion mass spectrometry,...
Endoscopic treatment of Barrett's oesophagus often leads to further damage healthy tissue causing fibrotic formation termed as strictures. This study shows that synthetic, self‐assembling peptide hydrogels (PeptiGelDesign) support the activity and function primary oesophageal cells, leading epithelialization stratification during in vitro 3D co‐culture. Following buffering culture media, rat stromal fibroblasts (rOSFs) are incorporated into a library hydrogels, whereas mouse epithelial cells...
Abstract The functional replacement of tendon represents an unmet clinical need in situations rupture, grafting, and complex reconstruction, as usually there is a finite source healthy to use donors. microfibrous architecture critical the function tendon. This study investigates electrospun poly(ɛ‐caprolactone) scaffolds potential biomaterial substitutes for grafts. We assessed performance two electrospinning manufacturers (small‐ large‐scale) effect sterilization techniques—gamma...
Understanding the cracking behaviour of biological composite materials is practical importance. This paper presents first study to track interplay between crack initiation, microfracture and plastic deformation in three dimensions (3D) as a function tubule collagen fibril arrangement elephant dentin using situ X-ray nano-computed tomography (nano-CT). A nano-indenter with conical tip has been used incrementally indent test-pieces oriented at 0°, 45° 70° long axis tubules (i.e. radial tusk)....
Self-assembling peptide hydrogels (SAPH) are a popular biomaterial due to their biocompatibility with wide range of cell types, synthetic design, structural properties that provide more accurate 3D microenvironment, and potential for cell- and/or drug-delivery system. Mimicking solid tumors in vitro using is one method testing anti-cancer drug efficacy observing cancerous cell-ECM interactions within In this study, SAPH, PeptiGel®Alpha1, was used model the breast tumor microenvironment....
The polymeric blend of poly (lactic-co-glycolic acid) (PLGA) and polyisoprene (PI) has recently been explored for application as stents tracheal stenosis spring the treatment craniosynostosis. From positive results presented in other biomedical applications comes possibility investigating this material scaffold tissue engineering (TE), acquiring a deeper knowledge about by exploring new processing technique while attending to most fundamental demands TE scaffolds. PLGA/PI was processed into...
Timely, recent developments in X-ray microcomputed tomography (XμCT) imaging such as increased resolution and improved sample preparation enable nondestructive time-lapse of polymeric biomaterials when implanted soft tissue, which we demonstrate herein. Imaging the full three-dimensional (3D) structure an biomaterial provides new opportunities to assess micromechanics interface between implant tissues how this changes over time force is applied load-bearing musculoskeletal applications. In...
Understanding the cracking behaviour of biological compositematerials is practical importance. This paper presents first studyto track interplay between crack initiation, microfracture andplastic deformation in three dimensions as a function tubule andcollagen fibrils arrangement elephant dentin using situ X-ray nanocomputed tomography (nano-CT). A nano-indenter with conical tip hasbeen used to incrementally indent test-pieces oriented at 0°, 45°and 70° long axis tubules (i.e. radial tusk)....
The relationship of self-assembling peptide hydrogel (SAPHs) material properties with hepatocyte viability, metabolism and morphology using a series PeptiGel® SAPHs is presented. Negatively charged promote higher cell viability proliferation for hepatocytes rather than positively SAPHs. Alpha7, novel negatively constitutes an ideal environment in vitro the 3D culture hepatocytes, supporting major hepatic functions differentiated over 14 days. Specifically, cultured HepG2 cells within lead to...
Intervertebral disc (IVD) degeneration is a process that starts in the central nucleus pulposus (NP) and leads to inflammation, extracellular matrix (ECM) degradation, progressive loss of height. Early treatment IVD critical reduction low back pain related disability. As such, minimally invasive therapeutic approaches can halt reverse NP at early stages disease are needed. Recently, we developed novel injectable graphene oxide (GO) - self-assembling peptide FEFKFEFK (F: phenylalanine; K:...