A5059665300- Bone Tissue Engineering Materials
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Osteoarthritis Treatment and Mechanisms
- Crop Yield and Soil Fertility
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Growth and nutrition in plants
- Biofuel production and bioconversion
- Electrospun Nanofibers in Biomedical Applications
- Circadian rhythm and melatonin
- Food composition and properties
- Tissue Engineering and Regenerative Medicine
- Bioenergy crop production and management
- Bone fractures and treatments
- Muscle metabolism and nutrition
- Seed Germination and Physiology
- Physiological and biochemical adaptations
- Spectroscopy Techniques in Biomedical and Chemical Research
- Agricultural Science and Fertilization
- Vitamin C and Antioxidants Research
- Neuroendocrine regulation and behavior
- Plant nutrient uptake and metabolism
- Spaceflight effects on biology
University of Nottingham
1982-2024
University of Aberdeen
1990-2013
Queen's Medical Centre
2013
Monsanto (United States)
1983
Children's Hospital of Los Angeles
1981
University of Southern California
1981
Plant & Food Research
1979
Loughborough University
1979
Summary Two theories of how energy metabolism should be associated with longevity, both mediated via free‐radical production, make completely contrary predictions. The ‘rate living‐free‐radical theory’ ( Pearl, 1928 ; Harman, 1956 Sohal, 2002 ) suggests a negative association, the ‘uncoupling to survive’ hypothesis Brand, 2000 correlation positive. Existing empirical data on this issue is contradictory and extremely confused Rubner, 1908 Yan & Ragland 1975 Daan et al ., 1996 Wolf...
An innovative approach was developed to engineer a multi-layered chitosan scaffold for osteochondral defect repair. A combination of freeze drying and porogen-leaching out methods produced porous, bioresorbable with distinct gradient pore size (mean = 160-275 μm). Incorporation 70 wt% nano-hydroxyapatite (nHA) provided additional strength the bone-like layer. The showed instantaneous mechanical recovery under compressive loading did not delaminate tensile loading. supported attachment...
ABSTRACT The goal of this research is to understand the key factors affecting ethanol production from grain sorghum. Seventy genotypes and elite hybrids with a range chemical compositions physical properties selected ≈1,200 sorghum lines were evaluated for used study relationships composition, structure, features that affect yield fermentation efficiency. Variations 22% in 9% efficiency observed among 70 samples. Genotypes high low conversion efficiencies associated attributes may be...
Abstract Studies on the growth and development of Rumex obtusifolius seedlings under simulated shade conditions show that both light quantity quality contribute to observed responses. In situation plants have lower dry matter, leaf area net assimilation rates. Petiole elongation occurs only after transfer from non‐shade environments. The effects are related phytochrome photoequilibria set up by increased relative photon flux in far‐red found vegetation canopies.
Life-history theory assumes that animal life histories are a consequence of trade-offs between current activities and future reproductive performance or survival, because resource supply is limited. Empirical evidence for such in the wild common, yet investigations underlying mechanisms rare. may have both physiological ecological mediated costs. One hypothesized mechanism elevated energy metabolism increase reactive oxygen species production, leading to somatic damage thus compromising...
Abstract Biodegradable polymer scaffolds have great potential for regenerative medicine applications such as the repair of musculoskeletal tissues. Here, we describe development that blend hydrogel components with thermoplastic materials, combining unique properties both to create mouldable formulations. This study focuses on structural and mechanical composite scaffolds, produced by temperature‐sensitive poly( DL ‐lactic acid‐ co ‐glycolic acid) (PLGA)/poly(ethylene glycol) (PEG) particles...
While oxidative damage owing to reactive oxygen species (ROS) often increases with advancing age and is associated many age-related diseases, its causative role in ageing controversial. In particular, studies that have attempted modulate ROS-induced damage, either upwards or downwards, using antioxidant genetic approaches, generally do not show a predictable effect on lifespan. Here, we investigated whether dietary supplementation vitamin E (α-tocopherol) C (ascorbic acid) affected lifespan...
Endoscopic treatment of Barrett's oesophagus often leads to further damage healthy tissue causing fibrotic formation termed as strictures. This study shows that synthetic, self‐assembling peptide hydrogels (PeptiGelDesign) support the activity and function primary oesophageal cells, leading epithelialization stratification during in vitro 3D co‐culture. Following buffering culture media, rat stromal fibroblasts (rOSFs) are incorporated into a library hydrogels, whereas mouse epithelial cells...
Mesenchymal stem cells are the focus of intense research in bone development and regeneration. The potential microparticles as modulating moieties osteogenic response by utilizing their architectural features is demonstrated herein. Topographically textured varying microscale produced exploiting phase-separation a readily soluble sacrificial component from polylactic acid. influence topographical on primary human mesenchymal cell attachment, proliferation markers osteogenesis investigated....
The role of biomechanical stimuli, or mechanotransduction, in normal bone homeostasis and repair is understood to facilitate effective osteogenesis mesenchymal stem cells (MSCs) vitro. Mechanotransduction has been integrated into a multitude vitro tissue engineering strategies provides an means controlling cell behaviour towards therapeutic outcomes. However, the delivery mechanical stimuli exogenous MSC populations, post implantation, poses significant translational hurdle. Here, we...
ABSTRACT Nine sorghum cultivars (five inbred lines and four hybrids) were grown in 2006 three locations (Mount Hope, KS, Halstead, Plainview, TX) under different irrigation conditions evaluated for composition ethanol fermentation efficiency. The objective was to study, one growing season, the effects of genotype, location, on physical chemical properties efficiencies grain sorghum. Genotype had a significant effect composition, properties, yield. showed large variation starch (61.0–74.8%),...
Biomaterial-based approaches for bone regeneration seek to explore alternative strategies repair non-healing fractures and critical-sized defects. Fracture non-union occurs due a number of factors resulting in the formation Rigorous evaluation biomaterials relevant models assessment their potential translate towards clinical use is vital. Large animal experimentation can be used model fracture while scaling-up materials use. Growth modulate cell phenotype, behaviour initiate signalling...
SUMMARY We examined the effect of increasing photoperiod, at a constant low temperature, on body mass and energy budget bank vole Clethrionomys glareolus. Simultaneously, we determined hypothalamic gene expression neuropeptides receptors known to be involved in short-term balance. Despite an increase mass(approximately 10% initial mass), found no significant changes any energetic parameters (food intake, assimilation rate, resting metabolic rate total daily expenditure by doubly-labelled...
The effects of dietary antioxidant supplementation on oxidative stress and life span are confused. We maintained C57BL/6 mice at 7 ± 2°C supplemented their diet with α-tocopherol from 4 months age. Supplementation significantly increased (p = 0.042) median by 15% (785 days, n 44) relative to unsupplemented controls (682 43) also maximum (oldest 10%, p 0.028). No sex or treatment interaction were observed span, having no effect resting daily metabolic rate. Lymphocyte hepatocyte DNA damage...
<h3>Objective</h3>To develop a biodegradable, modified-release antibiotic pellet capable of eradicating biofilms as potential novel treatment for biofilm infections.<h3>Design</h3>Pellets containing poly(DL-lactic-co-glycolic acid) microparticles, rifampin and clindamycin hydrochloride (3.5%, 7%, or 28% by weight), carrier gel (carboxymethylcellulose poloxamer 407) were tested in vitro. Drug release was assessed using serial plate transfer testing high-performance liquid chromatography,...
Using phantom samples, we investigated the feasibility of spatially-offset Raman spectroscopy (SORS) as a tool for monitoring non-invasively mineralization bone tissue engineering scaffold in-vivo. The samples consisted 3D-printed scaffolds poly-caprolactone (PCL) and hydroxyapatite (HA) blends, with varying concentrations HA, to mimic mineralisation process. were covered by 4 mm layer skin simulate real in-vivo measurement conditions. At concentration HA approximately 1/3 that (~0.6 g/cm3),...