Abstract Introduction Cannabis-based medicines have a number of therapeutic indications, including anti-inflammatory and analgesic effects. The endocannabinoid receptor system, the cannabinoid 1 (CB ) 2 endocannabinoids, are implicated in wide range physiological pathophysiological processes. Pre-clinical clinical studies demonstrated that cannabis-based drugs potential inflammatory diseases, rheumatoid arthritis (RA) multiple sclerosis. aim this study was to determine whether key elements...

Background: The aim of this study was to compare the outcomes displaced distal radial fractures treated with a volar locking plate results such conventional method closed reduction and percutaneous wire fixation supplemental bridging external when required. Our ascertain whether use improves functional outcomes. Methods: A single-center, pragmatic, randomized controlled trial conducted in tertiary care institution. One hundred thirty patients (eighteen seventy-three years age) who had...

Objective Structural changes of osteoarthritis (OA) may occur in the absence pain. In this study, we aimed to identify histopathologic features that are associated with symptomatic knee OA. Methods Medial tibial plateaus and synovium samples were obtained at time total replacement (TKR) surgery for OA (advanced group) or postmortem from subjects who had not sought medical attention pain during last year life (non‐OA control group). To OA, compared patients advanced age‐matched non‐OA...

Background: Clinical studies of osteoarthritis (OA) suggest central sensitization may contribute to the chronic pain experienced. This preclinical study used monosodium iodoacetate (MIA) model OA joint investigate potential contribution spinal sensitization, in particular glial cell activation, behaviour this model. Experimental was induced rat by intra-articular injection MIA and (change weight bearing distal allodynia) assessed. Spinal cord microglia (Iba1 staining) astrocyte (GFAP...

To determine the prevalence of knee pain, radiographic osteoarthritis (RKOA), total replacement (TKR) and associated risk factors in male ex-professional footballers compared with men general population (comparison group).1207 ex-footballers 4085 UK were assessed by postal questionnaire. Current pain was defined as or around knees on most days previous month. Presence severity RKOA standardised radiographs using Nottingham Line Drawing Atlas (NLDA) a subsample 470 491 comparison group. The...

The aim of this study was to investigate whether ACL injury (ACLi) or meniscal increases the risk end-stage osteoarthritis (OA) resulting in total knee replacement (TKR).A matched case-control all TKRs performed UK between January 1990 and July 2011 recorded Clinical Practice Research Datalink (CPRD) undertaken. CPRD contains longitudinal data on approximately 3.6 million patients. Two controls were selected for each case TKR, age, sex general practitioner location as a proxy socioeconomic...

An innovative approach was developed to engineer a multi-layered chitosan scaffold for osteochondral defect repair. A combination of freeze drying and porogen-leaching out methods produced porous, bioresorbable with distinct gradient pore size (mean = 160-275 μm). Incorporation 70 wt% nano-hydroxyapatite (nHA) provided additional strength the bone-like layer. The showed instantaneous mechanical recovery under compressive loading did not delaminate tensile loading. supported attachment...

Abstract Objective To investigate the impact of an experimental model osteoarthritis (OA) on spinal nociceptive processing and role inhibitory endocannabinoid system in regulating sensory at level. Methods Experimental OA was induced rats by intraarticular injection sodium mono‐iodoacetate (MIA), development pain behavior assessed. Extracellular single‐unit recordings wide dynamic range (WDR) neurons dorsal horn were obtained MIA‐treated saline‐treated rats. The levels endocannabinoids...

Objective Describe the self-reported prevalence and nature of Olympic-career injury general health current residual symptoms in a self-selected sample retired Olympians. Methods 3357 Olympians from 131 countries completed cross-sectional online survey, distributed by direct email through World Association National Olympian Associations databases. The survey captured Olympic sport exposure, significant training competition history (lasting > 1 month), (eg, depression) during athlete’s...

A subset of osteoarthritis patients will experience chronic postoperative pain after total knee arthroplasty (TKA), but the source is unclear. The aim this exploratory study was to assess with and without TKA using magnetic resonance imaging (MRI), quantitative sensory testing (QST), clinical assessment assessments catastrophizing thoughts.Forty-six completed 6-month assessment. MRI findings were scored according Osteoarthritis Knee Score recommendation for Hoffa synovitis, effusion size...

An in vivo study of the effects mechanical loading on transport small solutes into normal human lumbar intervertebral discs (IVD) using serial postcontrast magnetic resonance imaging (MRI).To investigate influence a sustained load diffusion and out IVD.Diffusion is an important source disc nutrition IVD remains unknown.Forty (on MRI) 8 healthy volunteers were subjected to post contrast (Gadoteridol) 3 Tesla MRI 2 phases. In phase 1 (control), scanned at different time points--precontrast...

This study investigated aspects of the validity and reliability 30-item Disabilities Arm, Shoulder Hand patient-reported outcome measure (DASH) its relationship with shorter 11-item QuickDASH in patients Dupuytren's disease.Seven hundred fifty-nine DASH questionnaires were studied, covering pre- postoperative undergoing different treatments for disease. Items related to pain rose early after treatment before returning baseline, suggesting that studying is relevant during recovery. Across all...

Objective Pain is a major symptom of osteoarthritis (OA); currently available analgesics either do not provide adequate pain relief or are associated with serious side effects. The aim this study was to investigate the therapeutic potential targeting resolvin receptor system modify OA and pathology. Methods Gene expression 2 receptors (ALX ChemR23) quantified in synovium medial tibial plateau specimens obtained from patients at time joint replacement surgery. Two models were used for...

Phosphate-based glasses (PBGs) are bioactive and fully degradable materials with tailorable degradation rates. PBGs can be produced as porous microspheres through a single-step process, using changes in their formulation geometry to produce varying pore sizes interconnectivity for use range of applications, including biomedical use. Calcium phosphate have recently been proposed orthobiologics, based on vitro cytocompatibility ion release profile. In this study, made two PBG formulations...

Aims To determine mortality risk after first revision total hip arthroplasty (THA) for periprosthetic femoral fracture (PFF), and to compare this primary THA other common indications. Methods The study cohort consisted of THAs recorded in the National Joint Registry between 2003 2015, linked national data. First PFF, infection, dislocation, aseptic loosening were identified. We used a flexible parametric model estimate cumulative incidence function death at 90 days, one year, five years...

Seventy-four patients have had a one-stage proctocolectomy for the management of Crohn's disease. Indications operation were: acute colitis 28 per cent, chronic 39 perianal disease 13 proctitis and 8 bleeding 5 coexisting colonic malignancy 7 cent. There were two hospital deaths (2.7 cent), both associated with sepsis. Late (n = 13) most commonly reoperations recurrent 3), cardiovascular 4) colorectal carcinoma 1). Postoperative complications principally Cumulative reoperation rates at 10...

We examined prospectively collected data from 6782 consecutive hip fractures and identified 327 in 315 women aged ≤65 years. report on their demographic characteristics, treatment outcome compare them with a cohort of 4810 4542 > 65 The first significant increase age-related incidence fracture was at 45, rather than 50, which is when screening by the osteoporosis service starts most health areas. Hip younger are sustained population risk as result underlying disease. Mortality 46 times...