A5055438609- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Orthopaedic implants and arthroplasty
- Automotive and Human Injury Biomechanics
- Bone Tissue Engineering Materials
- Injury Epidemiology and Prevention
- Traffic and Road Safety
- Ultrasound Imaging and Elastography
- Advanced Sensor and Energy Harvesting Materials
- Neonatal Respiratory Health Research
- Cerebrovascular and Carotid Artery Diseases
- Bone health and osteoporosis research
- Anorectal Disease Treatments and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Shoulder Injury and Treatment
- Trauma Management and Diagnosis
- Muscle activation and electromyography studies
- Infant Development and Preterm Care
- Pelvic floor disorders treatments
- Acute Ischemic Stroke Management
- Pelvic and Acetabular Injuries
- Veterinary Orthopedics and Neurology
University of Nottingham
2014-2025
University of Calgary
2018
The University of Melbourne
2017-2018
The Royal Melbourne Hospital
2018
Foothills Medical Centre
2018
Liverpool Heart and Chest Hospital
2012
University of Liverpool
2012
Transport Research Laboratory (United Kingdom)
2012
University of Oxford
1996-2008
University of Bristol
1992-2002
We investigated the distribution of compressive ‘stress’ within cadaver intervertebral discs, using a pressure transducer mounted in 1.3 mm diameter needle. The needle was pulled along midsagittal lumbar disc with face either vertical or horizontal while subjected to constant force. resulting ‘stress profiles’ were analysed order characterise and stress each disc. A total 87 discs from subjects aged between 16 years examined.
A technique was developed for measuring the distribution of stress within loaded cadaveric intervertebral discs. strain-gauged membrane mounted on side a 1.3-mm diameter needle pulled through disc at constant speed. The orientation changed by rotating needle, so that profiles vertical and horizontal components compressive could be obtained. measurements were reproducible did not perturb tissue to any significant extent. Stress varied considerably between discs highly dependent severity...
The aim of the present study was to investigate efficacy infliximab for treatment extrapulmonary sarcoidosis. A prospective, randomised, double-blind, placebo-controlled trial conducted, with at 3 and 5 mg·kg −1 body weight administered over 24 weeks. Extrapulmonary organ severity determined by a novel tool (extrapulmonary physician tool; ePOST) an adjustment number organs involved (ePOSTadj). In total, 138 patients enrolled in versus placebo chronic corticosteroid-dependent pulmonary...
We investigated the distribution of compressive ‘stress’ within cadaver intervertebral discs, using a pressure transducer mounted in 1.3 mm diameter needle. The needle was pulled along midsagittal lumbar disc with face either vertical or horizontal while subjected to constant force. resulting ‘stress profiles’ were analysed order characterise and stress each disc. A total 87 discs from subjects aged between 16 years examined. Our results showed that age-related degenerative changes reduced...
The intervertebral disk is routinely subjected to compressive loads that alter with posture and muscle activity can produce pressures = 2 MPa in human lumbar disks vivo (A. Nachemson G. Elfstrom. Scand. J. Rehabil. Med. 2, Suppl. 1:1-40, 1979; A. M. Morris. Bone Jt. Surg. Am. Vol. 46A: 1077-1092, 1964). We measured the effect of load on hydrostatic bovine caudal disks. With increase applied load, pressure increased linearly nucleus inner annulus. resting after slaughter (0.19 +/- 0.05 MPa)...
Study Design An in vivo experimental investigation of internal disc mechanics and discogenic pain. Objectives To test the hypotheses: 1) The pattern loading intervertebral discs is similar to that measured previously vitro; 2) stress concentrations also are found clinically degenerate vivo; associated with Summary Background Data Stress corresponding potentially painful patterns endplate have been observed vitro. Methods distribution within lumbar patients chronic pain was using...
The ability of materials to define the architecture and microenvironment experienced by cells provides new opportunities direct fate human pluripotent stem (HPSCs) [Robinton DA, Daley GQ (2012) Nature 481(7381):295-305]. However, conditions required for self-renewal vs. differentiation HPSCs are different, a single system that efficiently achieves both outcomes is not available [Giobbe GG, et al. Biotechnol Bioeng 109(12):3119-3132]. We have addressed this dual need developing hydrogel-based...
An in vivo study of the effects mechanical loading on transport small solutes into normal human lumbar intervertebral discs (IVD) using serial postcontrast magnetic resonance imaging (MRI).To investigate influence a sustained load diffusion and out IVD.Diffusion is an important source disc nutrition IVD remains unknown.Forty (on MRI) 8 healthy volunteers were subjected to post contrast (Gadoteridol) 3 Tesla MRI 2 phases. In phase 1 (control), scanned at different time points--precontrast...
Objective To assess the utility of a bespoke smartphone app to map noise and vibration exposure across neonatal road ambulance journeys. Design setting Prospective observational study journeys large UK transport service. Smartphones, with an in-house developed app, were secured incubator trolleys collect data for comparison international standards. A case exploring alternative routes between hospitals was undertaken. Results Over 12-month period, used from 1487 interhospital totalling 81 925...
The hypothesis was tested that stress concentrations in the posterior anulus of an intervertebral disc predispose it to prolapse under high compressive loads and anterolateral bending. distribution inside discs 22 cadaveric lumbar motion segments measured with specimens loaded pure compression combined Each segment then failure Failure occurred vertebral body (n = 12) or posterolateral 10); latter group showed a significantly greater incidence (P<0.001) anulus, when It concluded some are...
Loads acting on scoliotic spines are thought to be asymmetric and involved in progression of the deformity; abnormal loading patterns lead changes bone disc cell activity hence vertebral body wedging. At present however there no direct measurements intradiscal stresses or pressures spines. The aim this study was obtain quantitative stress environment intervertebral discs determine if loads across spine asymmetric. We performed vivo patients with scoliosis, both parallel (termed horizontal)...
This paper evaluates a technique for measuring the distribution of compressive stress within cadaveric intervertebral discs. A strain-gauged pressure transducer, side-mounted near tip 1.3 mm diameter needle, was inserted into cubes disc tissue and intact Regardless position orientation transducer or disc, its output found to be proportional force applied specimen. The measured by pulling instrumented needle through specimen resulting profiles were reproducible 20 per cent. Profiles obtained...
The hypothesis was tested that stress concentrations in the posterior anulus of an intervertebral disc predispose it to prolapse under high compressive loads and anterolateral bending. distribution inside discs 22 cadaveric lumbar motion segments measured with specimens loaded pure compression combined Each segment then failure Failure occurred vertebral body (n = 12) or posterolateral 10); latter group showed a significantly greater incidence (P < 0.001) anulus, when It concluded some are...
Inter-hospital transport of premature infants is increasingly common, given the centralisation neonatal intensive care. However, it known to be associated with anomalously increased morbidity, most notably brain injury, and mortality from multifactorial causes. Surprisingly, there have been relatively few previous studies investigating levels mechanical shock vibration hazard present during this vehicular pathway. Using a custom inertial datalogger, analysis software, we quantify linear head...
We present the development and validation of an image based speckle tracking methodology, for determining temporal two-dimensional (2-D) axial lateral displacement strain fields from ultrasound video streams. refine a multiple scale region matching approach incorporating novel solutions to known problems. Key contributions include automatic similarity measure selection adapt varying density, quantifying trajectory fields, spatiotemporal elastograms. Results are validated using tissue...