A5048188398- Liver Disease and Transplantation
- Non-Invasive Vital Sign Monitoring
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Muscle and Compartmental Disorders
- Drug-Induced Hepatotoxicity and Protection
- Complement system in diseases
- Electrolyte and hormonal disorders
- Blood groups and transfusion
- Cardiovascular Health and Disease Prevention
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Dermatology and Skin Diseases
- Organ Transplantation Techniques and Outcomes
- Autoimmune and Inflammatory Disorders Research
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Vascular anomalies and interventions
- Optical Imaging and Spectroscopy Techniques
- Mechanical Circulatory Support Devices
University of Rostock
2015-2024
Universitätsmedizin Rostock
2011-2019
Pediatric Nephrology of Alabama
2009-2010
•In a first-in-man, randomized-controlled trial of DIALIVE vs. standard care, the primary endpoint safety was met.•DIALIVE achieved acceptable performance characteristics for albumin exchange and reduction in endotoxin.•DIALIVE significantly reduced time to resolution ACLF improved prognostic scores compared with care.•DIALIVE had greater impact on pathophysiologically relevant biomarkers associated ACLF. Background & AimsAcute-on-chronic liver failure (ACLF) is characterized by severe...
Albumin is an important transport protein for non-water-soluble protein-bound drugs and uraemic toxins. Its capacity reduced in patients with advanced chronic kidney disease (CKD) unbound fractions of toxins are related to complications CKD. We investigated whether this reduction could be quantified how it correlated the stages Albumin-binding (ABiC) a dye-based method that quantifies remaining binding one major site (site II) albumin molecule.Blood samples from 104 CKD were incubated...
Experience with therapeutic plasma exchange (TPE) for acute relapses in clinically isolated syndrome (CIS) or multiple sclerosis (MS) patients has been derived from small and inhomogeneous patient populations so far. In the present study, we retrospectively evaluated features associated TPE response a larger cohort of CIS MS worsening disease.Ninety symptoms were firstly treated TPE. The population consisted 62 women 28 men median age 38 years (range 18-69 years).Primary endpoint was...
Abstract Thyrotoxic crisis (thyroid storm) is a life‐threatening condition. Standard therapy based on thiamazole, prednisolone, and nonselective beta‐blockers. Extracorporeal plasmapheresis an additional tool for removing circulating thyroxine in patients who do not respond quickly to conventional standard therapy. As can be bound by albumin, the aims of present report were investigate potential extracorporeal single‐pass albumin dialysis (SPAD) remove thyroid hormones compare it with...
Neutrophil granulocytes are the first defense line in bacterial infections. However, also responsible for severe local tissue impairment. In order to use donor granulocytes, but at same time avoid side effects, we developed an extracorporeal immune support system. This first-in-man study investigated whether plasma treatment with a granulocyte bioreactor is tolerable patients septic shock. A further intention was find suitable efficacy end-points subsequent controlled trials.The trial...
Hemophagocytic lymphohistiocytosis is a life-threatening clinical syndrome caused by severe hypercytokinemia brought on highly stimulated but ineffective immune response. Animal studies and case series have demonstrated that reduction in blood cytokine levels achieved with an extracorporeal adsorption cartridge contains blood-compatible porous polymer beads (CytoSorb ® ) can effectively attenuate the inflammatory response during sepsis possibly improve outcomes. We report of two patients...
Clinically Isolated Syndromes (CIS) summarize clinical features of possible multiple sclerosis (MS) as a first event the disease. Escalation therapy in CIS episodes comprises high dose glucocorticosteroid (GCS) treatment followed by therapeutic plasma exchange (TPE) patients unresponsive to GCS. The aim our study was analyze TPE effects patients. Eleven GCS-unresponsive exhibiting were treated with TPE. A median 5.0 (range 3-8) treatments performed volume 3.0 L 2.2-3.5 L). Standard...
Liver failure is associated with an accumulation of toxic molecules that exert affinity to albumin. Some them have vasoactive activity. So far, albumin has been used as a plasma expander improve the available circulating blood volume. However, recent studies suggested more effective than starch for this indication. It not reported yet whether industrial stabilizers octanoate and N-acetyltryptophanate, added albumin, occupy binding sites substances. The aim study was determine presence...
Therapeutic options to treat multiple sclerosis (MS) relapses comprise glucocorticosteroids (GCS) as first-line and therapeutic plasma exchange (TPE) second-line treatments in GCS-unresponsive patients. No guidelines exist for the treatment of another relapse following TPE. We retrospectively analyzed responsiveness GCS a subsequent TPE previously MS Thirty-seven patients with received (relapse A). All developed after completion again B). The primary study endpoint was clinical response...
The paper will describe the novel multi-wavelength photometric device OxyTrue Hb® which is capable to measure hemoglobin (Hb) and methemoglobin (MetHb) concentration non-invasively. Clinic trails in blood donation centers during dialysis are done prove demonstrate performance of system. results compared gold standard, BGA measurement.
Abstract Extracorporeal liver support procedures based on albumin dialysis require the use of pharmaceutical‐grade human serum (HSA). Those preparations contain octanoate, which is added as stabilizer during production process. For a direct involvement in pathogenesis failure complications well an indirect influence by competitive displacement effects at molecule have been described. During five Single Pass Albumin Dialysis (SPAD) and three Molecular Adsorbent Recirculating System (MARS)...
Haemodialysis patients have been found to an increased risk of developing Pneumocystis pneumonia (PcP) compared the control population. To best our knowledge, no data are available on pulmonary colonization with jirovecii in haemodialysis patients; therefore, aim this study was determine prevalence P. patients, and find related factors. Induced sputa 62 were investigated using quantitative polymerase chain reaction for presence jirovecii. 20.9% colonized 46.2% whom had CD4 cell counts below...
Abstract: Neutrophils are critical effector cells in humoral and innate immunity play a vital role phagocytosis bacterial killing. If they and/or their specific functions lacking, then immunoparalysis may occur, severe diseases like systemic inflammatory response syndrome (SIRS) or sepsis can take fatal course. In this paper, we discuss the possibility of using preconditioned an extracorporeal biohybrid immune support system. A human promyelocytic cell line was stimulated for different times...
Non-invasive and continuous accurate monitoring of a patients cardiovascular system can help to assure the early detection potential abnormalities trigger prompt hemodynamic assessment. Such an assessment is possible due current advances in optical spectroscopy signal processing. This paper presents novel sensor which facilitates real-time standard pulse oximetry parameters additionally total haemoglobin (Hb) concentration, cardiac output other important parameter. New algorithms were tested...
Our patient exhibited a large tumor on his right upper arm where former dialysis access site had been. X-ray, Doppler ultrasound, and magnetic resonance imaging scan could not fully reveal the nature of that tumor. Eventually, surgical approach showed giant aneurysm inflowing brachial artery to partially obliterated arteriovenous fistula. This case highlights importance ongoing care for patients with shunts. Even fistulas, are or no longer in use, can, especially when immunosuppressant...
<h3>Background and Aims</h3> Treatment of ACLF is an unmet need. DIALIVE a novel liver dialysis device that replaces dysfunctional albumin removes PAMPs DAMPs. This RCT tests the hypothesis improves prognosis patients. Primary endpoint was safety, other endpoints included clinical pathophysiologic effects performance. <h3>Method</h3> EUH2020 funded RCT. Patients population had Grades 1–3a, main were evaluated at Day 10. For patient to be evaluable, they 3–5 sessions. No specific...
The left-ventricular stroke volume is an important direct indicator of the heart efficiency and perfusion vessels. Currently a valid measurement beat can only be implemented by invasive measurements procedures at hospitals worldwide. Arterial catheterization limited to intensive care unit (ICU) usage, costly potential risky. Some available noninvasive methods yield rather ability track relative changes. Values delivered these techniques are highly subjective controversial . Enhanced pulse...