A5052789086- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Protein Interaction Studies and Fluorescence Analysis
- Renal function and acid-base balance
- Hemoglobin structure and function
- Drug-Induced Hepatotoxicity and Protection
- Mass Spectrometry Techniques and Applications
- Iron Metabolism and Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Lipid Membrane Structure and Behavior
- Neonatal Health and Biochemistry
- Hemoglobinopathies and Related Disorders
- Respiratory viral infections research
- Infant Nutrition and Health
- Muscle metabolism and nutrition
- Drug Transport and Resistance Mechanisms
- Dialysis and Renal Disease Management
- Analytical Methods in Pharmaceuticals
- Vitamin C and Antioxidants Research
- Organ Transplantation Techniques and Outcomes
- Clinical Laboratory Practices and Quality Control
- Metabolism and Genetic Disorders
- Microbial Inactivation Methods
- Dysphagia Assessment and Management
- Pharmacological Effects and Toxicity Studies
EduInnovation
2017
Charité - Universitätsmedizin Berlin
2007
•In a first-in-man, randomized-controlled trial of DIALIVE vs. standard care, the primary endpoint safety was met.•DIALIVE achieved acceptable performance characteristics for albumin exchange and reduction in endotoxin.•DIALIVE significantly reduced time to resolution ACLF improved prognostic scores compared with care.•DIALIVE had greater impact on pathophysiologically relevant biomarkers associated ACLF. Background & AimsAcute-on-chronic liver failure (ACLF) is characterized by severe...
Background and Aims Circulating albumin in cirrhosis can be dysfunctional because of accumulating structural damages, leading to the concept effective concentration (eAlb), referring portion presenting functional integrity. We aimed estimate eAlb patients with decompensated analyze its relationships function clinical outcomes as compared total (tAlb). Approach Results evaluated 319 hospitalized for acute decompensation (AD) without acute‐on‐chronic liver failure (ACLF) 18 age‐ sex‐comparable...
Human serum albumin (HSA) as the most abundant plasma protein carries multifunctional properties. A major determinant of efficacy relies on its potent binding capacity for toxins and pharmaceutical agents. Albumin is impaired in pathological conditions, affecting function a molecular scavenger. Limited knowledge available functional properties critically ill patients with sepsis or septic shock. prospective, non-interventional clinical trial assessed blood samples from 26 intensive care...
ABSTRACT Background Albumin, as the most abundant plasma protein, represents a target structure for both drug and physicochemical therapeutic approaches to eliminate uraemic toxins more efficiently. Potentially, this approach could reduce mortality of haemodialysis patients. However, little is known about albumin functional properties in these patients its alteration by treatment. Methods The binding detoxification efficiency were assessed electron paramagnetic resonance spectroscopy using...
<h3>Background and Aims</h3> Treatment of ACLF is an unmet need. DIALIVE a novel liver dialysis device that replaces dysfunctional albumin removes PAMPs DAMPs. This RCT tests the hypothesis improves prognosis patients. Primary endpoint was safety, other endpoints included clinical pathophysiologic effects performance. <h3>Method</h3> EUH2020 funded RCT. Patients population had Grades 1–3a, main were evaluated at Day 10. For patient to be evaluable, they 3–5 sessions. No specific...
Maintenance haemodialysis patients have increased morbidity and mortality which is mainly driven by an elevated inflammation level due to the uraemic milieu. A major part of this degree oxidative stress can be assessed albumin redox state (ARS). Aim study was evaluate how ARS affected a treatment different dialyzer properties.ARS determined before after fractionating it into reduced human mercaptalbumin (HMA), reversibly oxidized non-mercaptalbumin 1 (HNA-1), irreversibly 2 (HNA-2)...
<h3>Background</h3> In ACLF, systemic inflammation (SI) due to pathogen and damage associated molecular patterns (PAMPs DAMPs), albumin endothelial dysfunction results in organ failure. DIALIVE, a liver dialysis device replaces dysfunctional removes PAMPs DAMPs. randomised controlled trial, DIALIVE resolved ACLF faster greater proportion of patients compared with standard care (SOC). This substudy aimed evaluated the effect on pathophysiological processes that are causally ACLF....
Early diagnosis of human cancer is crucial importance for successful therapies. Cancer via ESR (electron-spin-resonance) spectroscopy albumin found in blood provides a new promising approach. The frontend signal processing follows protocol our proprietary dasiamobility molecular structure testpsila (MMS-Test) and real-valued 33-dimensional vector representation per sample, which combines representative feature set the binding ability (spin-probes) under investigation. Classical statistical...
Diagnostic medicine has significantly changed during the past decade. The emergence of proteomics and genomics increased our understanding disease. These fields have also revealed vast array proteins that are expressed in various disease processes, such as cancer. Measurement these unique certain diseases may offer diagnostic clues or allow patient prognosis to be assessed. Another approach is measure effects ligands on structure function albumin. Albumin known play an important role...