A5079669725- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Anesthesia and Neurotoxicity Research
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Anesthesia and Sedative Agents
- Polyomavirus and related diseases
- Blood Coagulation and Thrombosis Mechanisms
- Viral Infections and Immunology Research
- Complement system in diseases
- Clinical Nutrition and Gastroenterology
- Systemic Lupus Erythematosus Research
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Clostridium difficile and Clostridium perfringens research
- Vascular anomalies and interventions
- Intraoperative Neuromonitoring and Anesthetic Effects
- Aortic Disease and Treatment Approaches
- Hemodynamic Monitoring and Therapy
- Dermatological and COVID-19 studies
- Pericarditis and Cardiac Tamponade
Friedrich Schiller University Jena
2023-2025
Jena University Hospital
2023-2025
University of Rostock
2015-2024
Medizinische Hochschule Brandenburg Theodor Fontane
2023
Universitätsmedizin Rostock
2016-2022
University Medical Center
2022
University Hospital and Clinics
2022
Geriatric Research Education and Clinical Center
2020
Vanderbilt University Medical Center
2020
LMU Klinikum
2020
Sepsis-associated encephalopathy (SAE) contributes to mortality and neurocognitive impairment of sepsis patients. Neurofilament (Nf) light (NfL) heavy (NfH) chain levels as biomarkers for neuroaxonal injury were not evaluated in cerebrospinal fluid (CSF) plasma patients with sepsis-associated before. We conducted a prospective, pilot observational study including 20 septic shock five without serving controls. The assessment SAE comprised neuropsychiatric examination, electroencephalography...
Brain homeostasis deteriorates in sepsis, giving rise to a mostly reversible sepsis-associated encephalopathy (SAE). Some survivors experience chronic cognitive dysfunction thought be caused by permanent brain injury. In this study, we investigated neuroaxonal pathology sepsis.We conducted longitudinal, prospective translational study involving (1) experimental sepsis an animal model; (2) postmortem studies of from patients with sepsis; and (3) prospective, longitudinal human cohort at...
Advances in spine surgery enable technically safe interventions older patients with disabling disease, yet postoperative delirium (POD) poses a serious risk for recovery. This study investigates biomarkers of pro-neuroinflammatory states that may help objectively define the pre-operative POD. enrolled aged ≥60 scheduled elective under general anesthesia. Biomarkers state included S100 calcium-binding protein β (S100β), brain-derived neurotrophic factor (BDNF), Gasdermin D, and soluble...
Experience with therapeutic plasma exchange (TPE) for acute relapses in clinically isolated syndrome (CIS) or multiple sclerosis (MS) patients has been derived from small and inhomogeneous patient populations so far. In the present study, we retrospectively evaluated features associated TPE response a larger cohort of CIS MS worsening disease.Ninety symptoms were firstly treated TPE. The population consisted 62 women 28 men median age 38 years (range 18-69 years).Primary endpoint was...
Qualitative assessment by the Heckmatt scale (HS) and quantitative greyscale analysis of muscle echogenicity were compared for their value in detecting intensive care unit-acquired weakness (ICU-AW). We performed ultrasound (MUS) eight skeletal muscles on day 3 10 after ICU admission. calculated global mean score (MGS), z-score (MZS) (MHS). Longitudinal outcome was defined modified Rankin (mRS) Barthel index (BI) 100 days. In total, 652 pictures from 38 critically ill patients (18 with 20...
Abstract Background Enterovirus infection has been described as a cause of severe viral sepsis in humorally immunosuppressed patients. Case presentation A 20-year-old female with history multiple sclerosis on ocrelizumab therapy persistent agammaglobulinemia and autoimmune hepatitis treated azathioprine/budesonide presented subacute sensorineural hearing loss, hepatitis, pneumonia, enterocolitis pancreatitis. Molecular pathological techniques detected enterovirus RNA samples from the liver,...
Delirium manifests with comparable clinical presentations, regardless of its heterogeneous etiology. This suggests a final common pathway such as decreased electroencephalography (EEG) phase coupling. study investigates if amplitude coupling, another mode neural communication, is altered in delirium due to different etiologies. We analyzed EEGs patients from three sites either postoperative, poststroke or medical and non-delirious control patients. Amplitude envelope correlation corrected...
Delirium following cardiac surgery is a relevant complication in the majority of elderly patients but its prediction challenging. Cardiopulmonary bypass, essential for many interventions surgery, responsible severe inflammatory response leading to neuroinflammation and subsequent delirium. Neurofilament light protein (NfL) tau (tau) are specific biomarkers detect neuroaxonal injury as well glial fibrillary acidic (GFAP), marker astrocytic activation.We thought examine perioperative course...
Intensive care unit-acquired weakness (ICU-AW) is associated with poorer outcome of critically ill patients. Microcirculatory changes and altered vascular permeability skeletal muscles might contribute to the pathogenesis ICU-AW. Muscular ultrasound (MUS) displays increased muscle echogenicity, although its uncertain.We investigated combined measurement serum markers assess ICU-AW clinical patient outcome.Fifteen patients five healthy controls were longitudinally assessed for signs at study...
Background: Therapeutic plasma exchange (TPE) is frequently used in glucocorticosteroid (GCS)-refractory multiple sclerosis (MS) relapses. Data regarding predictors of treatment response are scarce. The objective this study was to analyze predictive factors for TPE GCS-refractory MS patients. Methods: A total 118 patients two tertiary centers were analyzed. Primary outcome defined as marked, mild, or no improvement. Secondary change expanded disability status scale (ΔEDSS). ΔEDSS and relapse...
Prospective quasi-experimental observational study.
Clinically Isolated Syndromes (CIS) summarize clinical features of possible multiple sclerosis (MS) as a first event the disease. Escalation therapy in CIS episodes comprises high dose glucocorticosteroid (GCS) treatment followed by therapeutic plasma exchange (TPE) patients unresponsive to GCS. The aim our study was analyze TPE effects patients. Eleven GCS-unresponsive exhibiting were treated with TPE. A median 5.0 (range 3-8) treatments performed volume 3.0 L 2.2-3.5 L). Standard...
Purpose. Liver dysfunction and failure are severe complications of sepsis result in poor outcome increased mortality. The underlying pathologic mechanisms hepatocyte necrosis during only incompletely understood. Here, we investigated whether procalcitonin, a biomarker sepsis, modulates liver cell function viability. Materials Methods. Employing previously characterized patented biosensor system evaluating toxicity vitro, human hepatocellular carcinoma cells (HepG2/C3A) were exposed to...
Purpose. Granulocyte transfusions have been used to treat immune cell dysfunction in sepsis. A granulocyte bioreactor for the extracorporeal treatment of sepsis was tested a prospective clinical study focusing on dosage norepinephrine patients and influence dynamic based liver tests during therapies. Methods Patients. Ten with severe were treated twice within 72 h system containing granulocytes from healthy donors. Survival, physiologic parameters, extended hemodynamic measurement,...
Intensive care unit-acquired weakness (ICU-AW) is one of the most frequent causes neuromuscular dysfunction in intensive medicine. To date no evidence-based recommendations exist for diagnostics, monitoring or further treatment.To evaluate current clinical practice and treatment strategies ICU-AW on units Germany.We conducted an online survey with a self-designed questionnaire invited 448 members Scientific Working Group Care Medicine (WAKI) Neuroanesthesia (WAKNA) to participate.A total...
Background and Objectives: Intensive care unit-acquired weakness (ICU-AW) is one of the most frequent neuromuscular complications in critically ill patients. We conducted a global survey to evaluate current practices diagnostics, treatment prevention patients with ICU-AW. Materials Methods: A pre-survey was created international experts. After revision, final endorsed by European Society Care Medicine (ESICM) using online platform SurveyMonkey®. In 27 items, we addressed strategies therapy...
Abstract Background The diagnosis of intensive care unit (ICU)-acquired weakness (ICUAW) and critical illness neuromyopathy (CINM) is frequently hampered in the clinical routine. We evaluated a novel panel blood-based inflammatory, neuromuscular, neurovascular biomarkers as an alternative diagnostic approach for ICUAW CINM. Methods Patients admitted to ICU with Sequential Organ Failure Assessment score ≥ 8 on 3 consecutive days within first 5 well healthy controls were enrolled. Medical...