A5020824942- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Cardiomyopathy and Myosin Studies
- Cyclopropane Reaction Mechanisms
- Estrogen and related hormone effects
- Steroid Chemistry and Biochemistry
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Porphyrin and Phthalocyanine Chemistry
- Catalytic Alkyne Reactions
- Photodynamic Therapy Research Studies
- Amino Acid Enzymes and Metabolism
- Electron Spin Resonance Studies
- Enzyme Structure and Function
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Hormonal Regulation and Hypertension
- Synthetic Organic Chemistry Methods
- Pharmacogenetics and Drug Metabolism
- Metabolism and Genetic Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Natural product bioactivities and synthesis
- Cancer Research and Treatments
- Carbon dioxide utilization in catalysis
- Hormonal and reproductive studies
Engelhardt Institute of Molecular Biology
2015-2024
Bauman Moscow State Technical University
2020
University of North Carolina at Charlotte
2013-2019
Russian Academy of Sciences
2010-2018
An efficient preparative method for the synthesis of siloxanols based on aerobic Co(OAc)<sub>2</sub> or Cu(OAc)<sub>2</sub>/NHPI-catalyzed oxidation hydride siloxanes has been proposed.
Abstract A new strategy for the three‐component addition of halide anions and acetylenes to donor–acceptor cyclopropanes (DACs) is presented. This reaction, which occurs with high E selectivity, promoted by gallium(III) salts based on 1,2‐zwitterionic reactivity DACs. It opens up a group processes involving The reaction readily broad range substrates tolerant various functional groups. methodology makes it possible assemble highly functionalized vinyl halides, are very convenient building...
A new synthetic concept was suggested in the chemistry of substituted methylidenemalonates that enables their utilization as 1,2-zwitterionic synthons. This strategy is to generate liquid ionic Ga complexes from and GaHal3 with a strict 3/4 composition then use them further synthesis. number different metal halides have been synthesized studied detail. The unique properties gallium among all metals demonstrated explained. On basis discovered class methylidenemalonates, novel reactions...
Fast changes in environmental oxygen availability translate into shifts mitochondrial free radical production. An increase intraerythrocytic reduced glutathione (GSH) during deoxygenation would support the detoxification of exogenous oxidants released circulation from hypoxic peripheral tissues. Although reported, mechanism behind this acute oxygen-dependent regulation GSH red blood cells remains unknown. This study explores role hemoglobin (Hb) modulation levels cells. We have demonstrated...
We have used two complementary time-resolved spectroscopic techniques, dipolar electron-electron resonance and fluorescence energy transfer to determine conformational changes in a single structural element of the myosin motor domain, relay helix, before after recovery stroke. Two double-Cys mutants were labeled with optical probes or spin labels, interprobe distances determined. Both methods resolved distinct states myosin, corresponding straight bent conformations helix. The state was...
The product of p53-induced gene 1 is a member the galectin family, i.e., galectin-7 (Gal-7). To move beyond structural data by X-ray diffraction, we initiated study lectin nuclear magnetic resonance (NMR) and circular dichroism spectroscopies, molecular dynamics (MD) simulations. In concert, our results indicate that lactose binding to human Gal-7 induces long-range effects (minor conformational shifts changes in dynamics) throughout protein result stabilization dimer state, with evidence...
Synthesis of organosilicon products with a "polar" functional group within organic substituents is one the most fundamentally and practically important challenges in today's chemistry silicones. In our study, we suggest solution to this problem, viz., high-efficiency preparative method based on aerobic Co-/N-hydroxysuccinimide (NHSI) catalyzed oxidation p-tolylsiloxanes p-carboxyphenylsiloxanes. This approach "green", commercially available, simple, inexpensive reagents employs mild reaction...
A new strategy for modifying the reactivity of donor–acceptor cyclopropanes (DAC) has been suggested. It involves use isomeric styrylmalonates as alternative sources reactive intermediates. The efficiency approach demonstrated in reactions with aromatic aldehydes. As a result, process construction 5,6-dihydropyran-2-one skeleton developed. efficiently occurs high diastereoselectivity presence BF3·Et2O; products can be easily isolated by crystallization. subsequent resulting dihydropyranones...
The novel class of gallium catalysts based on cationic phthalocyanines (RPcGa+) with SbF6– and Sb2F11– weakly coordinating anions was developed in order to using the catalytic version for gallium-specific chemistry. Two cycloaddition/annulation processes styrylmalonates aromatic aldehydes styrene were implemented this approach. synthetic strategy their structural features studied details, including use specially adapted 71Ga NMR spectroscopy combination 19F 121Sb ones, as well mechanistic aspects.
A new cascade process for reactions of donor-acceptor cyclopropanes (DACs) with spiro[cyclopropanepyrazolines] in the presence EtAlCl2 or Ga halides is reported. The action a Lewis acid results DAC activation and addition carbocationic intermediate to azocyclopropane system pyrazoline opening second three-membered ring halide anion from acid. specific feature this that one activated cyclopropane activates another one, depending on component ratio, can involve two molecules molecule...
The first selective process of formal [2+2]‐cycloaddition donor–acceptor cyclopropanes (DAC) to multiple C–C bonds form a four‐membered ring in the product has been developed. Bicyclobutylidene is used do demonstrate this reaction. promoted by GaCl 3 and occurs through generation 1,2‐zwitterionic intermediates. A carbocationic rearrangement bicyclobutylidene moiety. It results expansion both cyclobutane rings into five‐membered ones formation [2.3.3]propellane skeleton final product.
This study presents a methodology for the synthesis of ionic cyclopropenium-derived triplatinum cluster complex [(Ph3C3)2Pt3(MeCN)4]2+(BF4–)2 and its analogue with replacement one BF4– anions Cl– anion, which represents chain coordination polymer in crystalline form. The structures complexes were studied by several physicochemical methods, primarily X-ray diffraction using synchrotron radiation 195Pt NMR spectroscopy solution measurement analysis 195Pt–195Pt 13C–195Pt spin–spin coupling...
An aptamer is a synthetic oligonucleotide with unique spatial structure that provides specific binding to target. To date, several aptamers hemagglutinin of the influenza A virus have been described, which vary in affinity and strain specificity. Among them, DNA RHA0385 able recognize hemagglutinins highly variable sequences. In this paper, was studied by circular dichroism spectroscopy, nuclear magnetic resonance, size-exclusion chromatography, demonstrating formation parallel G-quadruplex...
Candida albicans and non-albicans species are a common cause of human mucosal infections, as well bloodstream infections deep mycoses. The emergence resistance spp. to antifungal drugs used in practice requires the search for new antimycotics. present study unravels potential synthetic dialk(en)ylthiosulfinates comparison with an enzymatic situ methionine γ-lyase-based thiosulfinate generation system (TGS). kinetics TGS reaction, namely, γ-lyase-catalyzed β-elimination S-alk(en)yl-L-cysteine...