A5042261152- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Hedgehog Signaling Pathway Studies
- Mitochondrial Function and Pathology
- Genetic and Kidney Cyst Diseases
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Mosquito-borne diseases and control
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Renal and related cancers
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Malaria Research and Control
- ATP Synthase and ATPases Research
- Genetics and Neurodevelopmental Disorders
- Chromatin Remodeling and Cancer
- Vector-borne infectious diseases
- Developmental Biology and Gene Regulation
- Cancer, Hypoxia, and Metabolism
- Melanoma and MAPK Pathways
- Parasites and Host Interactions
- Redox biology and oxidative stress
Memorial Sloan Kettering Cancer Center
2016-2023
Institute of Developmental Physiology
2023
The University of Texas Southwestern Medical Center
2006-2015
Research Institute for Tropical Medicine
2005-2011
Southwestern Medical Center
2006-2009
NeuroDevelopment Center
2008
Abstract We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results the development low-grade to high-grade progressive astrocytomas. When tumors achieve high grade, they are frequently accompanied by Akt activation, reminiscent frequent association PTEN mutations human glioma. In present study, we introduced CNS heterozygosity Pten into Nf1/p53 astrocytoma model. Resulting had accelerated morbidity, shortened survival, full...
The cellular origin of gliomas remains a topic controversy in cancer research. Advances neurobiology, molecular genetics, and functional genomics have ushered new insights through exploiting the development more sophisticated tools to address this question. Diverse distinct cell populations adult brain been reported give rise gliomas, although how these studies relate physiologically mechanisms spontaneous tumour formation via accumulation tumour-initiating mutations within single are less...
Malaria rapid diagnostic tests (RDTs) are now widely used for prompt on-site diagnosis in remote endemic areas where reliable microscopy is absent. Aberrant results, whereby negative test results occur at high parasite densities, have been variously reported over a decade and led to questions regarding the reliability of clinical use.In first trial, serial dilutions recombinant HRP2 antigen were tested on an HRP2-detectiing RDT. In second culture-derived Plasmodium falciparum parasites...
Glioblastoma multiforme (GBM), the most common and aggressive primary brain malignancy, is incurable despite best combination of current cancer therapies. For development more effective therapies, discovery novel candidate tumor drivers urgently needed. Here, we report that peroxiredoxin 4 (PRDX4) a putative driver. PRDX4 levels were highly increased in majority human GBMs as well mouse model GBM. Reducing expression significantly decreased GBM cell growth radiation resistance vitro with...
Malaria rapid diagnostic tests (RDTs) are a potential breakthrough in the provision of accurate diagnosis remote areas, but widescale use is hampered by uncertainty over accuracy under field conditions. Positive control wells, which contain recombinant malaria parasite antigen, novel method for addressing this need quality assurance. The commercially available positive well, reconstituted with blood, was assessed routine monitoring RDT sensitivity malaria-endemic region. When maintained at 4...
Abstract A central question in glioblastoma multiforme (GBM) research is the hierarchy of tumor-initiating cells, and its contribution to malignant phenotype genomic make-up GBM. We examine potential adult lineage restricted nervous system (CNS) progenitors form gliomas. show that targeting Nf1,p53 Pten mutations CNS but not stem cells gives rise fully penetrant identify two phenotypically molecularly distinct GBM subtypes arise from different progenitor lineages. Using multiple inducible...
A central question in glioblastoma research is the identity of tumor-initiating cell and its contribution to malignant phenotype genomic state. We systematically examined potential adult CNS progenitors, immature mature neurons induce fully penetrant using lineage-specific inducible cre mice inactivate tumor suppressors Nf1, Trp53 Pten. Adult progenitors give rise phenotypically molecularly distinct subtypes, which, despite histologic as glioblastoma, are separable based on lineage origin....
<div>Abstract<p>We previously reported that central nervous system (CNS) inactivation of <i>Nf1</i> and <i>p53</i> tumor suppressor genes in mice results the development low-grade to high-grade progressive astrocytomas. When tumors achieve high grade, they are frequently accompanied by Akt activation, reminiscent frequent association <i>PTEN</i> mutations human glioma. In present study, we introduced CNS heterozygosity <i>Pten</i>...
Supplementary Figure 1 from <i>Pten</i> Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas
Supplementary Figure 1 from <i>Pten</i> Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas