A5008603463- Antifungal resistance and susceptibility
- Gut microbiota and health
- Diet and metabolism studies
- Fungal Infections and Studies
- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Inflammatory Bowel Disease
- Nail Diseases and Treatments
- Fungal Biology and Applications
- Medicinal Plants and Neuroprotection
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Parasitic Diseases Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Rabies epidemiology and control
- Gastrointestinal motility and disorders
- Dental Research and COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Venomous Animal Envenomation and Studies
- Advanced Cellulose Research Studies
- Nerve injury and regeneration
Texas Center for Infectious Disease
2019-2023
The University of Texas at San Antonio
2019-2023
University of North Carolina at Chapel Hill
2013-2017
Government of Western Australia Department of Health
2015
Speech Pathology Australia
2015
Curtin University
2015
The University of Western Australia
2015
Kenyon College
2015
Karolinska Institutet
2015
Communities In Schools of Orange County
2013
Objective The relevance of the microbe-gut-brain axis to psychopathology is interest in anorexia nervosa (AN), as intestinal microbiota plays a critical role metabolic function and weight regulation. Methods We characterized composition diversity AN, using stool samples collected at inpatient admission (T1; n = 16) discharge (T2; 10). At T1, participants completed Beck Depression Anxiety Inventories Eating Disorder Examination–Questionnaire. Patients with AN were compared healthy individuals...
Inflammatory bowel diseases (IBD) result from dysregulated immune responses toward microbial and perhaps other luminal antigens in a genetically susceptible host, are associated with altered composition diversity of the intestinal microbiota. The interleukin 10-deficient (IL-10 (-/-) ) mouse has been widely used to model human IBD; however specific alterations that occur microbiota this during onset colonic inflammation have not yet defined. aim our study was define changes IL-10 mice...
ABSTRACT Food-borne pathogens are ongoing problems, and new emerging. The impact of fungi, however, is largely underestimated. Recently, commercial yogurts contaminated with Mucor circinelloides were sold, >200 consumers became ill nausea, vomiting, diarrhea. Mucoralean fungi cause the fatal fungal infection mucormycosis, whose incidence has been continuously increasing. In this study, we isolated an M. strain from a yogurt container, multilocus sequence typing identified as f. . most...
ABSTRACT Microbial protease-mediated disruption of the intestinal epithelium is a potential mechanism whereby dysbiotic enteric microbiota can lead to disease. This was investigated using colitogenic, protease-secreting microbe Enterococcus faecalis . Caco-2 and T-84 epithelial cell monolayers mouse colonic were exposed concentrated conditioned media (CCM) from E. V583 lacking gelatinase gene ( gelE ). The flux fluorescein isothiocyanate (FITC)-labeled dextran across or following exposure...
Objective This study examined associations between the composition and diversity of intestinal microbiota measures depression, anxiety, eating disorder psychopathology, stress, personality in a group healthy adult females. Methods Female participants (n = 91) ages 19–50 years with BMI 18.5–25 kg/m2 were recruited from central North Carolina July 2014 March 2015. Participants provided single fecal sample completed an online psychiatric questionnaire that included five measures: (i) Beck...
Mucor is intrinsically resistant to most known antifungals, which makes mucormycosis treatment challenging. Calcineurin a serine/threonine phosphatase that widely conserved across eukaryotes. When calcineurin function inhibited in , growth shifts less virulent yeast form, an attractive target for development of new antifungal drugs. Previously, we identified two distinct mechanisms through can become inhibitors involving Mendelian mutations the gene FKBP12, including corresponding A or B...
Abstract Anorexia nervosa, a severe psychiatric illness, is associated with an intestinal microbial dysbiosis. Individual signatures dominate in healthy samples, even over time and under controlled conditions, but whether markers of the disorder overcome inter‐individual variation during acute stage illness or renourishment unknown. We characterized daily changes microbiota three acutely ill patients anorexia nervosa entire course hospital‐based found significant, patient‐specific...
Adherent-invasive Escherichia coli (AIEC), a functionally distinct subset of resident intestinal E. associated with Crohn's disease, is characterized by enhanced epithelial adhesion and invasion, survival within macrophages, biofilm formation. Environmental factors, such as iron, modulate production extracellular structures, which in turn influence the formation multicellular communities, biofilms, bacterial interactions host cells. However, physiological functional responses AIEC to...
Genome instability is detrimental for living things because it induces genetic disorder diseases and transfers incorrect genome information to descendants. Therefore, organisms have evolutionarily conserved signaling networks sense repair DNA damage. However, how the damage response pathway regulated maintaining integrity of fungal pathogens this contributes their pathogenicity remain elusive. In study, we investigated in basidiomycete pathogen Cryptococcus neoformans , which causes...
The fecal microbiota of Korean patients with inflammatory bowel disease (IBD) was investigated respect to phenotypes and taxonomic biomarkers for diagnosis prognosis IBD.Fecal samples from 70 ulcerative colitis (UC) patients, 39 Crohn's (CD) 100 healthy control individuals (HC) were collected. amplified via polymerase chain reaction sequenced using Illumina MiSeq. relationships between bacteria clinical analyzed the EzBioCloud database 16S microbiome pipeline.The alpha-diversity...
Infections triggered by pathogenic fungi cause a serious threat to the public health care system. In particular, an increase of antifungal drug-resistant has resulted in difficulty treatment. A limited variety drugs available treat patients left us situation where we need develop new therapeutic approaches that are less prone development resistance fungi. this study, demonstrate efficacy nanoemulsion NB-201, which utilizes surfactant benzalkonium chloride, against human-pathogenic We found...
Procedures such as solid-organ transplants and cancer treatments can leave many patients in an immunocompromised state. This leads to their increased susceptibility opportunistic diseases fungal infections.
Abstract Background Glutamate is one of the major neurotransmitters in central nervous system. It a potent neurotoxin capable neuronal destruction through numerous signal pathways when present high concentration. Glutamate-evoked excitotoxicity has been implicated etiology many neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s (PD), and ischemic stroke. Increasing evidence shown that reactive oxygen species (ROS) provoked by glutamate-linked oxidative stress plays...
Angiogenesis mediated by proteins such as Fibroblast Growth Factor-2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to the disease state associated with various microbial infections. Previous studies our group others have shown that Candida albicans, common agent candidiasis, induces FGF-2 secretion vitro angiogenesis brains kidneys during systemic However, underlying mechanism(s) via which fungus increases production role(s)...
Warfighters are exposed to life-threatening injuries daily and according the Joint Trauma System Military Clinical Practice Guideline-Global Snake Envenomation Management snakebites a concerning threat in all theaters of operation. venom is complex mixture toxins including phospholipases A2 (PLA2) snake metalloproteinases (SVMP) that produce myotoxic, hemotoxic, cytotoxic injuries. Antibody-based antivenom standard care but new approaches small-molecule inhibitors have gained attention...
Angiogenesis mediated by proteins such as Fibroblast Growth Factor – 2 (FGF-2) is a vital component of normal physiological processes and has also been implicated in contributing to disease state associated with various microbial infections. Previous studies our group others have shown that Candida albicans, common agent candidiasis, induces FGF-2 expression vitro, angiogenesis brains kidneys during systemic However, the underlying mechanism(s) via which fungus increases role(s)...
ABSTRACT Introduction Dental caries are a limiting factor in maintaining dental and medical readiness the military. Untreated can lead to dire health consequences. Consistent comprehensive access care is often limited due intensive operational demands on our nation’s warfighters. The standard of for surgical model where diseased tooth tissue surgically removed restored with appropriate restorative materials. While effective, it not practical military environment, especially under time...