A5007226207- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Electron Microscopy Techniques and Applications
- Advanced MRI Techniques and Applications
- Advanced Measurement and Metrology Techniques
- Optical measurement and interference techniques
- Digital Radiography and Breast Imaging
- Nerve injury and regeneration
- Nuclear Physics and Applications
- Enzyme Structure and Function
- 3D Printing in Biomedical Research
- Welding Techniques and Residual Stresses
- Quantum, superfluid, helium dynamics
- Non-Destructive Testing Techniques
- Laser-Plasma Interactions and Diagnostics
- Histone Deacetylase Inhibitors Research
- Additive Manufacturing Materials and Processes
- Advanced Chemical Physics Studies
- Graphene research and applications
- Laser Material Processing Techniques
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Stress, Anesthesia, and Immune Response
University College London
2020-2024
The Francis Crick Institute
2024
To report on a micro computed tomography (micro-CT) system capable of x-ray phase contrast imaging and increasing spatial resolution at constant magnification.
X-ray microtomography is a nondestructive, three-dimensional inspection technique applied across vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology, medical research. Phase-contrast imaging extends the domain application x-ray classes samples that exhibit weak attenuation, thus appearing with poor contrast in standard imaging. Notable examples are low-atomic-number materials, like carbon-fiber composites, soft matter, biological...
X-ray microtomography is a powerful non-destructive technique allowing 3D virtual histology of resected human tissue. The achievable imaging field-of-view, however limited by the fixed number detector elements, enforcing requirement to sacrifice spatial resolution in order image larger samples. In applications such as soft-tissue imaging, phase-contrast methods are often employed enhance contrast. Some these methods, especially those suited laboratory sources, rely on optical dimensions...
Dark-field imaging is an x-ray technique used to highlight subpixel, typically micrometer-scale, density fluctuations. It often alongside standard attenuation-based and also phase-contrast imaging, which both see regular use in tomography. We present dark-field computed tomography (CT) with a laboratory edge-illumination setup. The contrast shown increase linearly the path length through imaged object, prerequisite for of tomographic reconstruction approaches. A multimaterial, custom-built...
Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into array of independent circular beamlets are resolved by high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, enables three-dimensional reconstructions refractive index decrement, δ, attenuation coefficient, μ. In this work, angular sensitivity resolution 2DBT images in...
A bstract Tumor-associated macrophages (TAM) enhance cancer progression by promoting angiogenesis, extracellular matrix (ECM) remodeling, and immune suppression. Nerve infiltration is a hallmark of various cancers known to directly contribute tumor growth. However, the role TAM in intratumoral nerve growth remains poorly understood. In this study, we demonstrate that expressed distinct “neural growth” gene signature. actively neural within tumors promote neurites outgrowth. We identify...
We present a dynamic implementation of the beam-tracking x-ray imaging method providing absorption, phase, and ultrasmall angle scattering signals with microscopic resolution high frame rate. demonstrate method's ability to capture processes 22-ms time by investigating melting metals in laser additive manufacturing, which has so far been limited single-modality synchrotron radiography. The simultaneous availability three contrast channels enables earlier segmentation droplets, tracking...
Laser-plasma accelerators are compact linear based on the interaction of high-power lasers with plasma to form accelerating structures up 1000 times smaller than standard radiofrequency cavities, and they come an embedded X-ray source, namely betatron unique properties: small source size femtosecond pulse duration. A still unexplored possibility exploit comes from combining it imaging methods able encode multiple information like transmission phase into a single-shot acquisition approach. In...
Abstract In this work, the application of a time resolved multi-contrast beam tracking technique to investigation melting and solidification process in metals is presented. The use such allows retrieval three contrast channels, transmission, refraction dark-field, with millisecond resolution. We investigated different conditions characterize, at proof-of-concept level, features visible each channels. found that phase channel provides superior visibility density variations, allowing liquid...
X-ray dark-field imaging highlights sample structures through contrast generated by sub-resolution features within the inspected volume. Quantifying signals generally involves multiple exposures for phase retrieval, separating contributions from scattering, refraction, and attenuation. Here, we introduce an approach non-interferometric that presents a single-parameter representation of sample. This fuses attenuation signals, enabling reconstruction unified three-dimensional Notably, our...
The poor soft tissue contrast of X-ray CT necessitates agent use to improve diagnosis across disease applications, yet their detection sensitivity requires high injected doses, which restrict in at-risk populations. Dark-field imaging is emerging as a more sensitive alternative traditional attenuation-based imaging, leveraging scattered radiation produce contrast. Yet aside from large, short-lived microbubbles, the alternate physics dark-field has be exploited for development. Here we...
Edge illumination x-ray phase contrast imaging uses a set of apertured masks to translate effects into variation detected intensity. While the system is relatively robust against misalignment, mask movement during acquisition can lead gradient artifacts. A method has been developed correct images by quantifying misalignment post-acquisition and implementing correction maps remove artifact. Images woven carbon fiber composite plate containing porosity were used as examples demonstrate image...
X-ray dark-field imaging is used to visualize the ultra-small angle x-ray scattering signal that originates from sub-resolution density fluctuations within sample microstructure. Dark-field tomography using edge-illumination system presented as a tool for measuring this in three dimensions. Its applicability different fields shown through example images of multi-material phantom, tissue-engineered esophagus, pouch cell battery and short-fiber reinforced composite material. The multichannel...
X-ray dark-field imaging creates a representation of the sample where contrast is generated by subresolution features within volume under inspection. These are detected local measurement radiation field's angular distribution, and how it affected interaction with matter. typically requires taking multiple exposures for separating contributions to intensity arising from scattering, refraction attenuation; procedure often called phase retrieval. We propose an approach retrieve image single...
Two-directional beam-tracking (2DBT) is a method for phase-contrast imaging and tomography that uses an intensity modulator to structure the X-ray beam into array of independent circular beamlets are resolved by high-resolution detector. It features isotropic spatial resolution, provides two-dimensional phase sensitivity, enables three-dimensional reconstructions refractive index decrement, $\delta$, attenuation coefficient, $\mu$. In this work, we report on angular sensitivity resolution...
Abstract Edge illumination is an X-ray phase contrast imaging technique that allows for the recovery of differential and dark-field (also known as scattering) contrast, in addition to conventional attenuation based contrast. These signals are retrieved by analysing profile a series beamlets across detector. This can provide wealth information about sample, especially biological tissues which produce little using radiography. To perform signal retrieval, Gaussian curves be fit profiles...
X-ray micro tomography is a non-destructive, three-dimensional inspection technique applied across vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology medical research. Phase-contrast imaging extends the domain application classes samples that exhibit weak attenuation, thus appear with poor contrast in standard imaging. Notable examples are low-atomic-number materials, like carbon-fibre composites, soft matter biological tissues. We...