A5031285464- Colorectal Cancer Surgical Treatments
- Anorectal Disease Treatments and Outcomes
- Pelvic floor disorders treatments
- Hernia repair and management
- Antimicrobial Resistance in Staphylococcus
- Pelvic and Acetabular Injuries
- Stoma care and complications
- Microscopic Colitis
- Inflammatory Bowel Disease
- Bacterial Identification and Susceptibility Testing
- Diverticular Disease and Complications
- Colorectal and Anal Carcinomas
- Abdominal Surgery and Complications
- Colorectal Cancer Screening and Detection
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Congenital gastrointestinal and neural anomalies
- Inflammatory mediators and NSAID effects
- Bacterial biofilms and quorum sensing
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy-related medical research
- Hidradenitis Suppurativa and Treatments
- Pharmacogenetics and Drug Metabolism
- Pain Mechanisms and Treatments
- Infective Endocarditis Diagnosis and Management
Reinier de Graaf Hospital
2020-2024
Oxford University Hospitals NHS Trust
2015-2019
Churchill Hospital
2015-2019
University of Oxford
2015-2018
Oxford Health NHS Foundation Trust
2018
Creative Research Enterprises (United States)
2016
University Hospital of Geneva
2016
Athens Medical Center
2016
University Medical Center Utrecht
2009-2011
Utrecht University
2005-2009
Background The mecA gene, encoding methicillin resistance in staphylococci, is located on a mobile genetic element called Staphylococcal Cassette Chromosome mec (SCCmec). Horizontal, interspecies transfer of this could be an important factor the dissemination methicillin-resistant S. aureus (MRSA). Previously, we reported isolation closely related methicillin-susceptible Staphylococcus (MSSA), MRSA and potential SCCmec donor epidermidis isolate from same patient. Based fingerprint techniques...
Transanal total mesorectal excision (TaTME) offers a promising alternative to the standard surgical abdominopelvic approach for rectal cancer. The aim of this study was report two-centre experience technique, focusing on short-term and oncological outcome.From May 2013 2015, 40 selected patients with histologically proven adenocarcinoma underwent TaTME in two institutions were prospectively entered an online international registry.Forty (80% men, mean body mass index 27.4 kg/m2 ) requiring...
To study the acquisition and cross-transmission of Staphylococcus aureus in different intensive care units (ICUs).We performed a multicenter cohort study. Six ICUs 6 countries participated. During 3-month period at each ICU, all patients had nasal perineal swab specimens obtained ICU admission during their stay. All S. isolates that were collected genotyped by spa typing multilocus variable-number tandem-repeat analysis for analysis. A total 629 admitted to ICUs, 224 these found be colonized...
Subtotal colectomy (STC) is a well-established treatment for complicated and refractory ulcerative colitis (UC). A laparoscopic approach offers potentially improved outcomes. The aim of the study was to report our experience with STC UC in single large centre.From January 2007 May 2015, all consecutive patients undergoing were retrospectively analysed from prospectively managed database. Patients known Crohn's disease or those one-stage procedures excluded. Demographics, perioperative...
Robotic surgery has gained popularity for the reconstruction of pelvic floor defects. Nonetheless, there is no evidence that robot-assisted reconstructive either appropriate or superior to standard laparoscopy performance procedures it sustainable. The aim this project was address proper role robotic using expert opinion.We set up an international, multidisciplinary group 26 experts participate in a Delphi process on robotics as applied surgery. comprised urogynecologists, urologists, and...
Introduction: Parastomal hernia repair remains a challenge. We describe robotic retromuscular non-keyhole mesh using synthetically reinforced biological (Ovitex) for the of complex and/or recurrent parastomal and technical modifications we made along way to improve our technique. Methods: All patients underwent described repair. Data was collected in database retrospective analysis performed on direct postoperative results early follow-up. Results: Eleven operation. Median follow-up 12...
Mutational activation of the KRAS oncogene and overexpression cyclooxygenase-2 (COX-2) contribute to colorectal carcinoma (CRC) development, but relationship between these two events is unclear. This study was designed clarify that assess contribution KRAS-dependent COX-2 seeding CRC cells in liver their outgrowth as metastases an experimental mouse model.The effect RNA interference-mediated knockdown on expression activity tested murine C26 cells. The early metastatic tumor cell (by...
Internal rectal prolapse can lead to obstructed defecation, faecal incontinence and pain. In treatment of frail or technically difficult patients, a perineal approach is often used, such as Delorme's STARR. However, in case very high take-off prolapse, these procedures are challenging if not unsuitable. We present trans-anal endoscopic microsurgery surgical option for management this uncommon type specific cases.
The surgical approach to total mesorectal excision (TME) for rectal cancer has undergone a substantial evolution with the adoption of more minimally invasive procedures. Transanal TME (taTME) is latest advanced technique pioneered tackle difficult pelvic dissections. Areas covered: surgery from open laparoscopic, robotic and transanal techniques was explored in this review. outcomes date on approach, taTME, are reviewed future direction proposed. A literature search performed using Embase,...
Abstract Background As global use of surgical robotic systems is steadily increasing, simulation can be an excellent way for surgeons to acquire and retain their skills in a safe environment. To address the need training less wealthy parts world, affordable robot simulator (PoLaRS) was designed. Methods The aim this pilot study compare learning curve data PoLaRS prototype with those Intuitive Surgical’s da Vinci Skills Simulator (dVSS) establish face- construct validity. Medical students...
In advanced pelvic cancer it may be necessary to perform a total exenteration. such cases urinary tract reconstruction is usually achieved with the creation of an ileal conduit stoma on right side patient's abdomen and end colostomy separately left. The potential morbidity from second avoided by use double-barrelled wet (DBWC), as single stoma. Another advantage possibility using vertical rectus abdominis muscle flap for perineal reconstruction.All patients undergoing formation DBWC were...
Abstract Surgeons performing robotic-assisted laparoscopic surgery experience physical stress and overuse of shoulder muscles due to sub-optimal arm support during surgery. The objective is present a novel design prototype dynamic for robotic evaluate its ergonomics performance on the AdLap-VR simulation training device. was designed using mechanical engineering process: Technical requirements, concept creation, selection, 3D-design built prototype. A crossover study performed marble sorting...
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External rectal prolapse may require emergency admission in the elderly and comorbid population. We report safety efficacy of laparoscopic ventral rectopexy patients having an with external prolapse.A retrospective analysis was performed a prospective database all rectopexies from 2006. Outcome follow-up data were assessed.Of 812 performed, 28 included for analysis. The mean length hospital stay 13.0 days. All operations completed successfully without intra-operative complications. Four...
Currently, there is no consensus regarding the best treatment option in recurrent haemorrhoidal disease (HD), due to a lack of solid evidence. The Napoleon trial aims provide high-level evidence on comparative effectiveness and cost-effectiveness repeat rubber band ligation (RBL) versus sutured mucopexy haemorrhoidectomy patients with HD.This multicentre randomized controlled trial. Patients HD grade II III, ≥18 years age who had at least two RBL treatments last three are eligible for...
BACKGROUND: The increasing incidence of fecal incontinence and the use sacral neuromodulation have an impact on health care providers costs. OBJECTIVE: purpose this study was to investigate technical clinical success rates, complications, patient satisfaction implantation permanent nerve stimulation under local anesthesia. DESIGN: A cohort analysis consecutive patients with for over a period 1 year performed. SETTINGS: This conducted at specialized pelvic floor unit in tertiary center....
Pouch-vaginal fistula (PVF) is an uncommon but serious complication of ileo-anal pouch reconstruction. This study aimed to review the recent management PVF, in particular role anti-tumour necrosis factor (anti-TNF) drugs.All patients presenting for PVF our surgical service between 2007 and 2016 were studied. The median duration follow-up from diagnosis was 6 years. Details original surgery, timing presentation final outcome recorded. Primary gastrointestinal (GI) continuity (as defined by...