A5028800136- Optical Coherence Tomography Applications
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Ophthalmology and Visual Impairment Studies
- Photoacoustic and Ultrasonic Imaging
- Intraocular Surgery and Lenses
- Coronary Interventions and Diagnostics
- Advanced Fluorescence Microscopy Techniques
- Ophthalmology and Visual Health Research
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Optical measurement and interference techniques
- Digital Holography and Microscopy
- Corneal Surgery and Treatments
- Advanced X-ray Imaging Techniques
- Optical Imaging and Spectroscopy Techniques
- Angiogenesis and VEGF in Cancer
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Systemic Lupus Erythematosus Research
- Traumatic Brain Injury and Neurovascular Disturbances
Duke University
2016-2025
Duke Medical Center
2016-2025
Ophthalmology Associates (United States)
2022
Duke University Hospital
2014-2022
Duke University Health System
2019
In this paper, we present a novel technique, based on compressive sensing principles, for reconstruction and enhancement of multi-dimensional image data. Our method is major improvement generalization the multi-scale sparsity tomographic denoising (MSBTD) algorithm recently introduced reducing speckle noise. new technique exhibits several advantages over MSBTD, including its capability to simultaneously reduce noise interpolate missing Unlike our does not require an priori high-quality from...
Recent advances in Doppler techniques have enabled high sensitivity imaging of biological flow to measure blood velocities and vascular perfusion. Here we compare spectrometer-based wavelength-swept OCT implementations theoretically experimentally, characterizing the lower upper observable velocity limits each configuration. We specifically characterize washout limit for OCT, at which signal degradation results loss information, is valid both quantitative qualitative techniques. also clearly...
Segmentation of anatomical structures in corneal images is crucial for the diagnosis and study anterior segment diseases.However, manual segmentation a time-consuming subjective process.This paper presents an automatic approach segmenting layer boundaries Spectral Domain Optical Coherence Tomography using graph theory dynamic programming.Our robust to low-SNR different artifact types that can appear clinical images.We show our method segments three normal adult eyes more accurately compared...
Eye models are valuable tools that can help delineate the role of anatomical parameters on visual performance and guide design advanced ophthalmic instrumentation. We propose an optically accurate wide-field schematic eye reproduces complete aberration profile human across a wide field. The optical is based experimentally measured wavefront aberrations taken with four mm pupil for central 80° horizontal meridian (101 eyes) 50° vertical (10 eyes). Across entire field view, our model shows...
Ultrahigh speed optical coherence tomography (OCT) systems with >100 kHz A-scan rates can generate volumes rapidly minimal motion artifacts and are well suited for 4D imaging (volumes through time) applications such as intra-operative imaging. In systems, high OCT data acquisition efficiency (defined the fraction of usable A-scans generated during total is desired to maximize volumetric frame rate sampling pitch. However, current methods beam scanning using non-resonant resonant mirror...
<h3>Background/aims</h3> To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. <h3>Methods</h3> A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial laser custom sample arm consisting two indirect ophthalmic lenses. Twenty-seven subjects with (choroidal melanomas, choroidal naevi, sclerochoroidal calcification, retinitis pigmentosa, diabetic retinopathy, retinoschisis uveitis)...
Purpose: Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior similarly MRI. Methods: Macular spectral-domain OCT and brain MRI images previously acquired part of Singapore Epidemiology Eye Diseases were analyzed. The right in was automatically segmented. Optical segmentations corrected for display distortions requiring biometry data. fitted...
Abstract Keratoconus (KC) is the most common corneal ectatic disorder affecting >300,000 people in US. KC normally has its onset adolescence, progressively worsening through third to fourth decades of life. patients report significant impaired vision-related quality Genetic factors play an important role pathogenesis. To identify novel genes familial patients, we performed whole exome and genome sequencing a four-generation family. We identified potential variants PPIP5K2 PCSK1 genes....
Optical coherence tomography (OCT) systems utilize 2D scanning methods to acquire reflectance-based volumetric images of samples, such as the human retina, with micrometer-scale depth resolution. A common method for performing this at high speeds is use a pair sequential, single-axis galvanometer scanners. An undesired effect using separated scanners variation in beam position pupil plane, phenomenon known wander or wobble. This can lead loss signal and vignetting artifacts resulting images....
A novel piezoelectric scanning mirror design for endoscopic optical coherence tomography (OCT) is presented. OCT an interferometric technique providing microscopic tomographic sectioning of biological samples with mm-range penetration capability in tissue and suited integration endoscopes using fiber-based light delivery to the sample. The was designed provide wide-range rapid forwarding-looking beam at distal end a compact catheter. scanner provides large ratio aperture device size...
Optical coherence tomography (OCT) has seen widespread success as an in vivo clinical diagnostic 3D imaging modality, impacting areas including ophthalmology, cardiology, and gastroenterology. Despite its many advantages, such high sensitivity, speed, depth penetration, OCT suffers from several shortcomings that ultimately limit utility a microscopy tool, pervasive coherent speckle noise poor lateral resolution required to maintain millimeter-scale depths. Here, we present optical refraction...
Purpose: To evaluate the diagnostic performance of a robotically aligned optical coherence tomography (RAOCT) system coupled with deep learning model in detecting referable posterior segment pathology OCT images emergency department patients. Methods: A model, RobOCTNet, was trained and internally tested to classify as versus non-referable for ophthalmology consultation. For external testing, patients signs or symptoms warranting evaluation were imaged RAOCT. RobOCTNet used images. Model...
We present a method, termed distributed scanning OCT (DSOCT), which reduces the effects of patient motion on corneal biometry utilizing current-generation clinically available spectral domain optical coherence tomography (SDOCT) systems. first performed pilot study power spectrum normal axial eye based repeated (M-mode) SDOCT. Using DSOCT to reduce motion, we conducted preliminary comparing measured anterior and posterior curvatures calculated both topography Scheimpflug photography in...
Purpose: We advance studies of subretinal treatments by developing a microscope-integrated optical coherence tomography (MIOCT) image-based method for measuring the volume therapeutics delivered into space. Methods: A MIOCT measurement was developed and assessed accuracy reproducibility imaging an object known size in model eyes. This then applied to blebs created injection diluted triamcinolone. Bleb volumes obtained from were compared intended surgeon's estimation leakage. Results:...
Current conventional clinical OCT systems image either only the anterior or posterior eye during a single acquisition.This localized imaging limits OCT's use for characterizing global ocular morphometry and biometry, which requires knowledge of spatial relationships across entire eye.We developed "whole eye" optical coherence tomography system that simultaneously acquires volumes with wide field-of-view both chamber (14 x 14 mm) retina (55°) using source detector.This was used to measure...