A5048464269- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Cellular transport and secretion
- RNA Interference and Gene Delivery
- Chromatin Remodeling and Cancer
- Stress Responses and Cortisol
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- RNA modifications and cancer
- Treatment of Major Depression
- BRCA gene mutations in cancer
- Pluripotent Stem Cells Research
- Nuclear Structure and Function
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
Sun Yat-sen University
2019-2024
Sun Yat-sen Memorial Hospital
2019-2024
Abstract Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact most protein function have remained elusive. We develop PSPHunter, can precisely predict these residues based on machine learning scheme. In vivo in vitro validations demonstrate that truncating just 6 GATA3 disrupts separation, enhancing tumor migration inhibiting growth. Glycine its motifs are...
Xiaoyao pills (XYP) is a commercial Chinese patent medicine used in the treatment of depression. However, mechanisms underlying its therapeutic effects, as well patients who can benefit from XYP, have not been evaluated so far.
Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of protein regulate numerous cellular processes. However, effects PTMs on genome-wide binding CTCF organization three-dimensional (3D) structure have not been fully understood. In this study, we uncovered PTM profiling demonstrated that can be O-GlcNAcylated arginine methylated....
Abstract Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies improving efficiency of production in vitro . In this study, we developed a coupled screening strategy that took advantage an arrayed bi-molecular fluorescence complementation (BiFC) platform protein-protein interaction screens and epiblast-like (EpiLC)-induction assays using reporter mouse embryonic stem cells (mESCs). Investigation candidate partners core human pluripotent...
Polycomb group (PcG) ring finger protein 6 (PCGF6), though known as a member of the transcription-repressing complexes, PcG, also has activation function in regulating pluripotency gene expression. However, mechanism underlying PCGF6 is poorly understood. Here, we found that co-localizes to regions along with factors such OCT4. In addition, was recruited subset super-enhancer (SE) upstream cell cycle-associated genes by OCT4, and increased their By combining promoter capture Hi-C data,...