MicroRNAs (miRNAs), are ∼22 nucleotides long, non-coding RNAs that control gene expression post-transcriptionally by binding to their target mRNA's 3′UTRs (untranslated regions). Due roles in various important regulatory processes and pathways, miRNAs have been implicated disease mechanisms such as tumorigenesis when is deregulated. To date, a significant number of messenger (mRNAs) identified verified. It generally accepted can potentially bind many mRNAs, which brings the requirement...

CLX (celecoxib) is a highly hydrophobic non-steroidal anti-inflammatory drug with high plasma protein binding. We describe here the encapsulation of in MLVs (multilamellar vesicles) composed DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) and variable amounts cholesterol. The effects cholesterol content on liposome size, percentage loading vitro release profiles were investigated. Differential scanning calorimetry FTIR (Fourier-transform infrared) spectroscopy used to determine molecular...

In this study, the protective effect of amifostine, which is only FDA-approved radioprotective agent, was investigated against deleterious effects ionizing radiation on rat liver microsomal membranes at molecular level. Sprague−Dawley rats, were either administered amifostine or not, whole-body irradiated with a single dose 800 cGy and decapitated after 24 h. The isolated from livers these rats using FT-IR spectroscopy. results revealed that caused significant decrease in lipid-to-protein...

Multiple sclerosis (MS) is a chronic, progressive, inflammatory and degenerative disease of central nervous system. Here, we aimed to develop method for differential diagnosis Relapsing-Remitting MS (RRMS) clinically isolated syndrome (CIS) patients, as well identify CIS patients who will progress RRMS, from cerebrospinal fluid (CSF) by infrared (IR) spectroscopy multivariate analysis. Spectral analyses demonstrated significant differences in the molecular contents, especially lipids Z...

Diabetes mellitus is associated with a high incidence and poor prognosis of cardiovascular disease. The aim the present study was to examine effect relatively short-term (5 weeks) Type I diabetes on left ventricle, right ventricle vessel (vein) myocardium at molecular level by FTIR (Fourier-transform infrared) microspectroscopy. rats were categorized into two groups: control group (for myocardium, n=8; for n=9; vein, n=9) streptozotocin-induced diabetic n=7; n=8). Two adjacent cross-sections...

Several techniques have been used to identify and classify plants. We proposed Fourier transform infrared (FT-IR) spectroscopy, together with hierarchical cluster analysis, as a rapid noninvasive technique differentiate plants based on their leaf fragments. applied this three different genera, namely, Ranunculus (Ranunculaceae), Acantholimon (Plumbaginaceae), Astragalus (Leguminoseae). All of these genera are angiosperms include large number species in Turkey. ornamental importance, while is...

In recent years, Fourier Transform Infrared (FT-IR) spectroscopy has had an increasingly important role in the field of pathology and diagnosis disease states. current study, FT-IR together with cluster analysis were used as a diagnostic tool discrimination diabetic samples from control ones rat kidney plasma membrane apical sides (brush-border membranes), liver microsomal membranes Extensor digitorum longus (EDL) Soleus (SOL) skeletal muscle tissues. A variety alterations spectral...

Diabetes Mellitus (DM) is a metabolic disorder, characterized by abnormally high blood glucose levels due to decreased secretion or effectiveness in function of insulin. Having role carbohydrate and lipid metabolism, skeletal muscle affected the absence insulin diabetic conditions. This current study reports application Fourier transform infrared (FTIR) spectroscopy determination macromolecular alterations streptozotocin (STZ)-induced rat Soleus (SOL) muscles, which highlight promise this...