A5060995703- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular and Diving-Related Complications
- Pharmacological Effects and Toxicity Studies
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Brain Tumor Detection and Classification
- Intracranial Aneurysms: Treatment and Complications
- Prion Diseases and Protein Misfolding
- Cerebral Venous Sinus Thrombosis
- Congenital Heart Disease Studies
- Sleep and related disorders
- Neurogenesis and neuroplasticity mechanisms
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Healthcare Technology and Patient Monitoring
- Glycogen Storage Diseases and Myoclonus
- Anesthesia and Sedative Agents
- S100 Proteins and Annexins
- Diabetes Treatment and Management
- Vascular anomalies and interventions
Mayo Clinic in Arizona
2025
Houston Methodist
2022-2024
University of Auckland
2024
Methodist Hospital
2022-2024
University of Miami
2016-2018
Michigan Medicine
2018
Sinai Hospital
2018
LifeBridge Health
2018
UConn Health
2018
Washington University in St. Louis
2014-2018
Apolipoprotein E (apoE) is the strongest known genetic risk factor for late onset Alzheimer's disease (AD). It influences amyloid-β (Aβ) clearance and aggregation, which likely contributes in large part to its role AD pathogenesis. We recently found that HJ6.3, a monoclonal antibody against apoE, significantly reduced Aβ plaque load when given APPswe/PS1ΔE9 (APP/PS1) mice starting before of deposition. To determine whether anti-apoE HJ6.3 affects plaques, neuronal network function, behavior...
Amyloid β (Aβ) accumulates in the extracellular space as diffuse and neuritic plaques Alzheimer's disease (AD). Aβ also deposits on walls of arterioles cerebral amyloid angiopathy (CAA) most cases AD sometimes independently AD. Apolipoprotein E (apoE) ɛ4 is associated with increases both CAA humans. Studies mouse models that develop deposition have shown murine apoE human apoE4 different abilities to facilitate plaque or formation when studied independently. To better understand compare...
Background: This study was designed to estimate the costs of index hospitalizations after cardiac arrest in United States. Methods and Results: We used US Nationwide Inpatient Sample (2003–2012) identify patients with arrest. Log transformation inflation-adjusted cost determined for care patient outcomes. Overall, an estimated 1 387 396 were hospitalized The mean age cohort 66 years, 45% women, majority white. procedures included coronary angiography (15%), percutaneous intervention (7%),...
OBJECTIVE Thyroid disorder has been known to affect vascular function and associated with aortic aneurysm formation in some cases; however, the connection not well studied. The authors hypothesized that hypothyroidism is of cerebral aneurysms. METHODS performed a retrospective case-control study consecutive patients who had undergone angiography at an academic, tertiary care medical center period from April 2004 through 2014. Patients unruptured aneurysms were identified among those 3-vessel...
Ventricular dysfunction is common among patients with repaired cyanotic congenital heart disease. To date, no pharmacologic intervention has been demonstrated to be beneficial in this setting. begin addressing knowledge gap, we conducted a single-center prospective, randomized, open-label pilot study investigate the effects of eplerenone on serologic markers collagen turnover and inflammation, 6-minute walk distance, quality life tetralogy Fallot (TOF) or transposition great arteries...
The therapeutic window for acute ischemic stroke with intravenous recombinant tissue plasminogen activator (IV rt-PA) is brief and crucial. American Heart Association/American Stroke Association Target: Best Practice Strategies (TSBPS) aim to improve thrombolysis door-to-needle (DTN) time. We assessed the efficacy of implementation selected TSBPS reduce DTN time in a large tertiary care hospital. A multidisciplinary committee causes delayed implemented focused our urban academic medical...
Background: The current AHA stroke prevention guidelines give Class 1 recommendations that patients with AIS and diabetes should receive glucose-lowering agents cardiovascular benefit to reduce risk of MACE. ADA recommends in ASCVD, when further vascular events is the priority, a GLP1RA be added; concern for heart failure or chronic kidney disease SGLT2i added. Objective: Among cohort presenting AIS, we analyzed rates use during hospitalization and/or outpatient follow-up. Methods: A...
To describe the sensitivity, specificity, and negative positive predictive values of abnormal TTE for detection intracardiac thrombus on advanced cardiac imaging, to better characterize factors likely predict finding an abnormality imaging in cryptogenic strokes.
Background: The current AHA guidelines recommend (class IIb) advanced cardiac imaging in an embolic stroke of unknown source (ESUS). We aim to better characterize the role MRI (cMRI) evaluation patients and determine patient characteristics that may increase positive predictive value cMRI. Method: A retrospective review at a comprehensive center, who had cMRI between 12/2016 11/2020 was conducted using institutional registries. Ischemic with ESUS, cryptogenic (with ESUS as competing...
Objective: Effect of Hypothyroidism on Unruptured Cerebral Aneurysm Dimensions and Endovascular Coiling Outcome Background: In a previous case-control study, we found significant association history hypothyroidism with occurrence unruptured cerebral aneurysm in women within our patient cohort. has been shown to cause mucopolysaccharide deposition blood vessel wall weakening formation some case reports. We hypothesized that may also have larger size. Methods: We performed retrospective...
Background: Endocrine dysfunction, including thyroid function, has been known to affect cerebral vascular dysfunction. Hypothyroidism shown cause mucopolysaccharide deposition which associated with the weakening of blood vessel walls and aneurysm formation in some case reports. However, connection between hypothyroidism not well studied. We hypothesized that maybe occurrence aneurysms. Methods: performed a retrospective case-control study consecutive patients receiving angiography at our...
Background: The current AHA guidelines recommend (class IIb) advanced cardiac imaging in embolic stroke of unknown source (ESUS). We aim to better characterize the role CTA (cCTA) evaluation patients. Method: A retrospective review patients at a comprehensive center, who had cCTA between 12/2016 and 11/2020 was conducted using institutional registries. Ischemic with ESUS, cryptogenic (with ESUS as competing etiology) cardio-embolic etiologies were included. Only cardioembolic which suspicion...
Introduction: Thrombolytic window for acute ischemic stroke is brief and crucial. The AHA/ASA Target: Stroke Best Practice Strategies (TSBPS) aim to help hospitals improve thrombolysis door-to-needle (DTN) time. We assessed long-term efficacy of TSBPS reduce DTN in a tertiary care hospital. Methods: initiated quality improvement program across one regional academic medical center (1,550 beds, 900 annual admissions) that serves multi-ethnic population by establishing multidisciplinary...
We assessed long-term efficacy of implementation AHA/ASA Target: Stroke Best Practice Strategies (TSBPS) to improve thrombolysis door-to-needle (DTN) time in a tertiary care hospital.