A5075724184- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- NF-κB Signaling Pathways
- TGF-β signaling in diseases
- Injury Epidemiology and Prevention
- Lung Cancer Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Occupational and environmental lung diseases
- Respiratory Support and Mechanisms
- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- Protein Kinase Regulation and GTPase Signaling
University of Pittsburgh
2016-2020
Richard King Mellon Foundation
2020
Interstitial Cystitis Association
2016
Pulmonary and Allergy Associates
2016
Relaxin is a hormone that has been considered as potential therapy for patients with fibrotic diseases.To gauge the efficacy of relaxin-based therapies in idiopathic pulmonary fibrosis (IPF), we studied gene expression relaxin/insulin-like family peptide receptor 1 (RXFP1) IPF lungs and controls.We analyzed data obtained from Lung Tissue Research Consortium correlated RXFP1 cross-sectional clinical demographic data. We also employed ex vivo donor lung fibroblasts to test vitro. tested...
Abstract Idiopathic pulmonary fibrosis (IPF) is a disease characterized by the accumulation of apoptosis-resistant fibroblasts in lung. We have previously shown that high expression transcription factor Twist1 may explain this prosurvival phenotype vitro. However, observation has never been tested vivo. found loss COL1A2+ cells led to increased very significant T and bone marrow–derived matrix-producing cells. Twist1-null expressed levels cell chemoattractant CXCL12. In vitro, we IPF lung...
Klebsiella pneumoniae is a common cause of antibiotic-resistant pneumonia. Follistatin-like protein 1 (FSTL-1) highly expressed in the lung and critical for homeostasis. The role FSTL-1 immunity to bacterial pneumonia unknown. Wild-type (WT) hypomorphic (Hypo) mice were infected with determine infectious burden, immune cell abundance, cytokine production. Hypo/TCRδ-/- Hypo/IL17ra-/- also generated assess γδT17 cells this model. Hypo had reduced K. burden compared that WT controls. increased...
ABSTRACT Relaxin has been considered as a potential therapy for patients with pulmonary fibrosis. We have previously shown, however, that limitation of relaxin-based Idiopathic Pulmonary Fibrosis (IPF) is the loss expression relaxin receptor Relaxin/Insulin Like Receptor 1 (RXFP1) in fibroblasts. The molecular mechanism RXFP1 down-regulation IPF remains unclear. To determine whether microRNAs play role gene expression, we employed bioinformatics approach to identify (miRs) are predicted...