A5022724296- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Transplantation: Methods and Outcomes
- Neonatal Respiratory Health Research
- Medical Imaging and Pathology Studies
- GDF15 and Related Biomarkers
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Treatments and Mutations
- Cardiovascular Function and Risk Factors
- Nutrition and Health in Aging
- Air Quality and Health Impacts
- Virus-based gene therapy research
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Machine Learning in Materials Science
- Sepsis Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Peptidase Inhibition and Analysis
- Diabetes and associated disorders
- Inhalation and Respiratory Drug Delivery
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
Second Military Medical University
2025
Changhai Hospital
2025
University of Pittsburgh
2008-2024
South China Normal University
2023
Stony Brook University
1992
The transcriptional induction of the alpha or immediate-early gene class herpes simplex virus type 1 effected by trans-induction factor (alpha TIF, ICP25, VP16, Vmw65) requires an alpha-specific cis-acting site. Increased transcription does not result from direct, independent binding but rather TIF-dependent formation a protein-DNA complex containing, in addition to at least one host cell factor. One factors is POU domain protein which recognizes octamer element consensus. There evidence...
Background Deficits in gamma aminobutyric acid (GABA) neuron-related markers, including the GABA-synthesizing enzyme GAD67, calcium-binding protein parvalbumin, neuropeptide somatostatin, and transcription factor Lhx6, are most pronounced a subset of schizophrenia subjects identified as having ‘low GABA marker’ (LGM) molecular phenotype. Furthermore, shares degrees genetic liability, clinical features cortical circuitry abnormalities with schizoaffective disorder bipolar disorder. Therefore,...
Papillon Lefèvre syndrome (PLS) is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and severe periodontitis. The disease caused mutations in the cathepsin C gene (CTSC) that maps to chromosome 11q14. CTSC associated with PLS have been correlated significantly decreased enzyme activity. Mutational analysis of three North American families segregating identified four mutations, including a novel mutation p.G139R. All were dramatically reduced protease A homozygous...
We developed an automated approach to construct a complex reaction network and explore the mechanisms for numerous reactant molecules by integrating several theoretical approaches. Nanoreactor-type molecular dynamics was used generate possible chemical reactions, in which metadynamics overcome barriers, semiempirical GFN2-xTB method reduce computational cost. Reaction events were identified from trajectories using hidden Markov model based on evolution of connectivity. This provided starting...
Conventional spin-transfer torque random access memory (STT-RAM) is a promising technology due to its non-volatility and dense cell structure. However, the long switching time of magnetic tunneling junction (MTJ) limits write speed STT-RAM. In order improve performance, Spin-Hall Effect (SHE) assisted STT-RAM structure (SHE-RAM) has recently been proposed [1]. SHE effect eliminates incubation delay existing in conventional consequently, reduces energy. The corresponding read schemes have...
As part of our studies to identify the gene responsible for hereditary gingival fibromatosis, GINGF (OMIM 135300), we have identified and cloned a novel human that contains highly conserved methyltransferase domain characteristic S-adenosylmethionine-dependent methyltransferases. We localized this (C2orf8 encoding 288L6 SAM-methyltransferase) chromosome 2p22-->p21 by FISH, sublocalized it BAC RP11 flanked D2S2238 D2S2331. Computational analysis aligned ESTs ten exons in hypothetical C2orf8...
<h3>Introduction</h3> Idiopathic pulmonary fibrosis (IPF) is a rare progressive lung disease with limited treatment options and poor prognosis. Genome-wide association studies (GWAS) using additive genetic models which assumes an increase in risk for each copy of the coded allele, have identified multiple relevant genes. Since, variation complex traits could also be influenced by non-additive effects, we performed analyses dominant model, where one or more copies allele are sufficient to...
The 65-kDa herpes simplex virus type 1 encoded alpha trans-induction factor (alpha TIF or VP16) has two important functions: it is required for the efficient transcriptional induction of immediate-early genes, and acts as an essential structural component virion. transcription properties have been well studied in vitro. protein a powerful inducer RNA polymerase II-directed and, similar to cellular transactivators GAL4 CGN4, contains separable DNA binding transactivation domains. In contrast,...