Since the onset of coronavirus disease 2019 (COVID-19) pandemic, doctors and public authorities have demonstrated concern about reduction in quality care for other health conditions due to social restrictions lack resources. Using a population-based stroke registry, we investigated impact COVID-19 pandemic admissions Joinville, Brazil.

Abstract Background/Aims Longitudinal studies assessing the impact of genetic polymorphisms on outcomes in patients with Type 2 Diabetes Mellitus (T2DM) and Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) are scarce. This study aimed to evaluate effect PNPLA3 TM6SF2 risk alleles hepatic extrahepatic T2DM‐MASLD individuals. Methods Patients' were analysed as follows: CC, CG GG; CC CT + TT; combined comparing no mutant allele, one allele G or T ≥2 T. Hierarchical models built...

Abstract Background Bullous pemphigoid (BP) is the most common type of subepidermal bullous disease. The detection linear deposition immunoglobulin G (IgG) and/or C3 at dermo-epidermal junction using direct immunofluorescence (DIF) gold standard for diagnosis; however, it requires a fresh tissue specimen. Since immunohistochemistry (IHC) complement component C4d easy and more accessible, this technique can also serve as an efficient method. Our objective to compare IHC results with DIF in...

Purpose: Twist1 is a transcription factor that regulates embryonic development, stemness, and differentiation, can also stimulate initiation of tumorigenesis in peripheral solid cancers. However, its role central nervous system tumors, including medulloblastoma (MB), the main type malignant brain cancer afflicts children, remains poorly understood. Here, we examined expression Twist1, potential significance prognosis, different histological variants molecular subgroups MB. Methods: Gene data...

To compare the 90-day survival of critically ill people with COVID-19 and acute kidney injury in intensive care units (ICU) public private hospitals. This was a retrospective cohort study undergoing hemodialysis Joinville, Santa Catarina state. The rate ICU 15.7% (95%CI 8.4; 25.1), while it 37.7% 24.9; 50.5%). In multivariate analysis adjusted for sociodemographic variables (Hazard ratio (HR) 2.01; 95%CI 1.31; 3.08) comorbidities (HR 2.09; 1.30; 3.37), admission to associated higher risk...

Fibroblast growth factors (FGFRs) signaling are required for human tooth development. Its dysregulation affects formation and patients with FGFR2 mutations often present dental anomalies in the spectrum of syndrome. This study aimed to investigate whether genetic polymorphisms associated molar fused roots. The null hypothesis is that variations not isolated cases (non-syndromic) molars Panoramic radiographs non-syndromic were used assess occurrence roots molars. Genomic DNA analysis was...

To characterize patients with chronic critical illness and identify predictors of development illness.Prospective data was collected for 1 year in the intensive care unit a general hospital Southern Brazil. Three logistic regression models were constructed to factors associated illness.Among 574 subjects admitted unit, 200 submitted mechanical ventilation. Of these patients, 85 (43.5%) developed illness, composing 14.8% all unit. The model that evaluated association conditions present prior...

Objective and background: The aim of this in vitro study was to compare the efficiency a photodynamic therapy (PDT) technique employing rose bengal (RB) methylene blue (MB) as photosensitizers (PSs) reduce viability Enterococcus faecalis, well-known pathogen found root canal systems. Currently, several clinical applications, including field endodontics, MB is employed association with red laser source for photoinactivation pathogenic bacteria. Methods: In study, used at 0.01% (31.2 mol/L)...

ABSTRACT A number of reports have indicated an increased risk cirrhosis and hepatocellular carcinoma in hepatitis B virus (HBV)-infected individuals carrying HBV e antigen (HBeAg)-negative variants. Although distinct core promoter precore mutations distributed according to geographical locality viral genotype been reported, epidemiological data from South America are still scarce. The prevalences genotypes polymorphisms 75 HBeAg-negative Argentinean blood donors were surveyed. observed...

The prevalence and consequences of occult HBV infection in patients with chronic liver disease by HCV remain unknown.To evaluate the a population HCV-infected hepatocellular carcinoma.The serum samples were tested for DNA nested PCR tissue analysis was carried out using immunohistochemical technique 66 HBsAg-negative patients: 26 hepatitis (group 1), 20 carcinoma related to 2) negative viral markers B C (control group).Occult diagnosed 9/46 (19.5%) patients. Prevalence evaluated without...

Members of the Acinetobacter genus are key pathogens that cause healthcare-associated infections, and they tend to spread develop new antibiotic resistance mechanisms. Oxacillinases primarily responsible for carbapenem antibiotics. Higher rates hydrolysis might be ascribed insertion sequences, such as ISAba1 sequence, near bla OXA genes. The present study examined occurrence genetic elements their relationship with susceptibility carbapenems in clinical isolates calcoaceticus-Acinetobacter...

This article outlines and discusses Brazil's new regulations on the use of human biological materials for research, specifically, Resolution CNS 441/11, enacted by National Health Council Brazil in May 2011, Guidelines Biorepositories Biobanks (Ordinance No. 2201) published Ministry September 2011. The authors examine differences between sample collections single studies large-scale multiple (e.g., Tumor Bank at Brazilian Cancer Institute A. C. Camargo Hospital Biobank). Also discussed are...

INTRODUCTION: Carbapenems are the therapy of choice for treating severe infections caused by Acinetobacter calcoaceticus-Acinetobacter baumannii complex. We aimed to assess prevalence and antimicrobial susceptibility profiles producers distinct oxacillinases among nosocomial isolates A. calcoaceticus-A. complex in a 249-bed general hospital located Joinville, Southern Brazil. METHODS: Of 139 clinical with reduced carbapenems between 2010 2013, 118 from varying anatomical sites sectors were...

Urgent-start peritoneal dialysis (US-PD) has been proposed as a safe modality of renal replacement therapy (RRT) for end-stage disease (ESRD) patients with an indication emergency initiation. We aimed to compare the characteristics, 30-day complications, and clinical outcomes US-PD planned (Plan-PD) over first year therapy.This was single-center retrospective study that included incident adult followed up one year. considered when started within 7 days after Tenckhoff catheter implantation....

Background Stroke is the second leading cause of death in Brazil. The social and financial burden stroke remarkable; however, epidemiological profile remains poorly understood. Objective aim this study was to report incidence, lethality, functional status at 30 90 days post-stroke cities different Brazilian macro-regions. Methods This an observational, prospective, population-based study, led Canoas (South), Joinville (South, reference center), Sertãozinho (Southeast), Sobral (Northeast) It...

Justificativa e objetivos: Infecções Relacionadas à Assistência Saúde (IRAS) causadas por bacilos Gram negativos multirresistentes (BGN-MDR) são consideradas um problema de saúde pública impacto nas taxas mortalidade Unidades Terapia Intensiva (UTI). O objetivo deste estudo foi verificar o perfil fenotípico resistência colistina tigeciclina, como último recurso terapêutico aos BGN-MDR. Métodos: Os dados foram coletados fichas busca ativa do serviço controle infecções prontuários médicos...

A high prevalence of steatotic liver disease has been described in psoriasis. However, the influence genetic polymorphisms yet to be investigated this scenario. This study aims determine frequency steatosis, advanced fibrosis and PNPLA3/TM6SF2 genotypes individuals with psoriasis evaluate impact polymorphisms, metabolic parameters cumulative methotrexate dose on steatosis fibrosis. Cross-sectional that prospectively included outpatients, submitted clinical laboratory analysis, transient...

Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis Joinville, Brazil.All first-ever strokes that occurred Joinville 2010 were followed-up for five years.We included 334 patients. Over years, 156 died, 51 had a recurrent stroke, 128 free stroke. The overall cumulative risk death was 17% (95% CI, 13% 22%) at 30 days 47% 41% 52%) after years. Undetermined with incomplete investigation...

Ischemic stroke (IS) is a multifactorial disease that presents high rates of morbimortality in Brazil. Several studies proved there link between the ABO blood group system and occurrence thrombotic events. Nonetheless, its association with IS not well established.For reason, purpose hereof was to investigate relation groups Brazilian cohort cerebrovascular diseases.Five hundred twenty-nine subjects were included over 12 months, from which 275 presented an episode 254 composed control group....

The spread of carbapenemase- and extended-spectrum β-lactamase (ESBL)-producing gram-negative bacilli (GNB) represent a global public health threat that limits therapeutic options for hospitalized patients. This study aimed to evaluate the in-vitro susceptibility β-lactam-resistant GNB ceftazidime-avibactam (C/A) ceftolozane-tazobactam (C/T), investigate molecular determinants resistance.Overall, 101 clinical isolates Enterobacterales Pseudomonas aeruginosa collected from general hospital in...