A5091706398- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Renal cell carcinoma treatment
- Hormonal and reproductive studies
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Hormonal Regulation and Hypertension
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Neurological Complications and Syndromes
- Advanced Glycation End Products research
- Radiopharmaceutical Chemistry and Applications
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Urinary Tract Infections Management
- Neuroendocrine Tumor Research Advances
- Seaweed-derived Bioactive Compounds
- Cardiovascular Syncope and Autonomic Disorders
- Cancer survivorship and care
- Neurological and metabolic disorders
- Sirtuins and Resveratrol in Medicine
University of Fukui
2012-2024
University of Fukui Hospital
2022
Weatherford College
2021
Obayashi (Japan)
2021
Southern Illinois University School of Medicine
2019
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Abstract BACKGROUND Expression profiles of some microRNAs (miRNAs) were associated with clinicopathological findings in human prostate cancer (PC), but the relative expression miRNAs among Gleason patterns (GPs) remains unclear. In this study, we investigated several known each GP PC. METHODS Formalin‐fixed, paraffin embedded (FFPE) tissue samples obtained from radical prostatectomy (RP) (patient set 1, n = 43, including (GP 3) 22, 4) 35, and 5) 12) needle biopsy 2, 10, 10). Cancer tissues...
Abstract Aims The existence of Angiotensin‐II (Ang‐II) receptors in the bladder wall and pronounced contractile effect Ang‐II on human detrusor muscle have been well established. Studies presented role as a mediator smooth growth collagen production with outlet obstruction. We investigated associations between male lower urinary tract symptoms (LUTS) hypertension (HT), examined whether medications used for HT treatment, particularly receptor blockers (ARBs) influence LUTS. Methods Among...
α-1 blockers and dutasteride are widely used as agents to treat benign prostatic hyperplasia (BPH); the impact of these drugs on inflammation is still unclear. Herein, we investigated treatment BPH in terms degree inflammation. Tissue specimens were obtained from 143 patients who administered up until their operation. Thirty-three had also been treated with before procedure. The was quantified histologically by ratio high endothelial venule (HEV)-like vessels. We divided this retrospective...
Background Benign prostatic hyperplasia (BPH) is a common urologic disease in older men. Prostatic inflammation research has focused on the magnitude of inflammation; its location received little attention. We investigated whether anatomic related to severity lower urinary tract symptoms (LUTS), measured subjectively and objectively. Methods retrospectively analyzed hematoxylin+eosin‐stained tissue specimens from 179 BPH patients who underwent transurethral resection prostate (TURP) or...
This study aimed to evaluate the efficacy of androgen receptor signaling inhibitors (ARSIs) combined with deprivation therapy (ADT) for treating castration-sensitive metastatic prostate cancer in Japanese patients, focusing on effects time development castration-resistant (CRPC) and overall survival (OS). retrospective muti-institutional analysis included 332 patients diagnosed Japan between 2018 2023. The were categorized into two groups: receiving ADT ARSI (ARSI group) those alone or...
Abstract Stress-related peptide corticotropin-releasing factor (CRF) and CRF-related peptides are distributed in the peripheral viscera such as bladder. We investigated contribution of psychological stress (PS) CRF on bladder function. Male rats received sham (SS) or PS using a communication box method for 120 min every day 7 days. One group intraperitoneal CRF-R1 antagonist antalarmin days during exposure. Mean voided volume per micturition was significantly lower compared to SS rats, which...
Chemotherapy with docetaxel (DTX) is used for castration-resistant prostate cancer (CRPC), but it inadequate.We evaluated the effect of combination treatment DTX and mTOR inhibitor temsirolimus (TEM) in PC3 cell line, by focusing on induction autophagy apoptosis.TEM induced not apoptosis even at a high dose, whereas apoptosis. The low-dose TEM caused 34% suppression proliferation compared to monotherapy higher dose DTX. was increased their combination. overcame TEM. suppressed tumor growth...
Aims: Hyperinsulinemia is an important causative factor of prostate enlargement in type 2 diabetes (T2D), however, clinically weight increases during hypoinsulinemic condition. To investigate the pathogenesis and effects phosphodiesterase 5 inhibitor (PDE5i), male Otsuka Long-Evans Tokushima Fatty (OLETF) (LETO) rats were used as T2D control, respectively. Materials Methods: OLETF LETO treated with oral tadalafil (100 μg/kg/day) or vehicle for 12 wks from at age 36 wks. Key findings:...
Abstract Aims We evaluated the relationship between body mass index (BMI), including low BMI, and nocturia in Japanese women. Methods collected data on 18 952 women who participated a multiphasic health screening Fukui, Japan, 2006. The participants were asked to report any current or previous disease. Self‐reported weight height used calculate BMI. analyzed nocturia, as assessed by questionnaire, other variables age, comorbidities. Results participants’ mean age was 60.6 years. Overall,...
Decision-making to stop cancer treatment in patients with advanced is stressful, and it significantly influences subsequent end-of-life palliative treatment. However, little known about the extent which patient's self-decisions influenced prognostic period. This study focused on self-decision investigated impact of their post-cancer survival period place death.We retrospectively analyzed 167 cases genitourinary (kidney cancer: 42; bladder 68; prostate 57) treated at University Fukui Hospital...
Chronic prostatic inflammation is a critical factor that exacerbates lower urinary tract symptoms (LUTS). The serum C-reactive protein (CRP) level one of the most common markers with which to assess degree inflammation, and it has been reported be related severity LUTS. However, not clear whether CRP linked magnitude inflammation. We evaluated relationship between assessed influence on LUTS.We tissue specimens 121 benign hyperplasia (BPH) patients who underwent surgery for BPH preoperative...
<title>Abstract</title> Background This study aimed to evaluate the efficacy of androgen receptor signaling inhibitors (ARSIs) combined with deprivation therapy (ADT) for treating castration-sensitive metastatic prostate cancer in Japanese patients, focusing on effects time development castration-resistant (CRPC) and overall survival (OS). Methods retrospective muti-institutional analysis included 332 patients diagnosed Japan between 2018 2023. The were categorized into two groups: receiving...
ABSTRACT Purpose The bladder dysfunction associated with type 2 diabetes mellitus (T2DM) involves urine storage and voiding disorders. We evaluated the pathologic conditions of wall in a rat model T2DM effects phosphodiesterase-5 (PDE-5) inhibitor tadalafil (TA). Materials Methods Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats (LETO) comprised control groups. TA was orally administered for 12 weeks. blood flow ATP released from epithelium were measured using laser speckle imaging an...
Abstract This study examined whether nocturia can be improved by adhering to an appropriate bedtime among older adults. prospective comparative crossover included alternate 4-week intervention and non-intervention periods with a 2-week washout period. During the intervention, participants went bed at personalized bedtime, as determined data from wrist-wearable device. The frequency-volume chart Pittsburgh Sleep Quality Index were administered before after each analysis 24 of 33 patients...
Bladder dysfunction associated with type 2 diabetes mellitus (T2DM) includes urine storage and voiding disorders. We examined pathological conditions of the bladder wall in a rat T2DM model evaluated effects phosphodiesterase-5 (PDE-5) inhibitor tadalafil.
Introduction Neuroendocrine tumors originating in the kidney are rare, and standard treatments not established. Case presentation An 80‐years‐old man was referred to our hospital with renal dysfunction a left mass. Based on CT bone scintigraphy results, he diagnosed as having large tumor thrombus inferior vena cava, harboring lymph node, liver, lung, iliac metastasis. The biopsy indicated large‐cell neuroendocrine carcinoma. Treatment nivolumab + ipilimumab introduced. local metastatic had...