A5032916655- Hepatitis B Virus Studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Liver Disease Diagnosis and Treatment
- Influenza Virus Research Studies
- Liver Disease and Transplantation
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Respiratory viral infections research
- HIV/AIDS drug development and treatment
- COVID-19 epidemiological studies
- Trypanosoma species research and implications
- COVID-19 diagnosis using AI
- Research on Leishmaniasis Studies
- Mosquito-borne diseases and control
- Vaccine Coverage and Hesitancy
- Tracheal and airway disorders
- Glycosylation and Glycoproteins Research
- Vibrio bacteria research studies
- Thermal Regulation in Medicine
- Hedgehog Signaling Pathway Studies
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
2013-2024
Instituto de Investigaciones Biomédicas en Retrovirus y Sida
2022
University of Buenos Aires
2022
Marymount University
2022
Consejo Nacional de Investigaciones Científicas y Técnicas
2022
Hepatitis B Foundation
2010
Abstract Human metapneumovirus (hMPV) is a virus, which was first associated with acute lower respiratory infection in children but detected currently all age groups. Clinical symptoms are similar to those described for syncytial virus (RSV) infections, ranging from mild illness severe bronchiolitis and pneumonia children. To date, no cases of hMPV have been reported Argentina. In this study, 440 samples obtained during the period 1998–2002 under 5 years old were evaluated. Routine detection...
During the first few months of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution in a new host, contrasting hypotheses have been proposed about way virus has evolved and diversified worldwide. The aim this study was to perform comprehensive evolutionary analysis describe human outbreak rate different genomic regions SARS-CoV-2. molecular nine SARS-CoV-2 analyzed using three approaches: phylogenetic signal assessment, emergence amino acid substitutions, Bayesian...
Abstract Current diagnostic standards involve severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) detection in nasopharyngeal swabs (NPS), but saliva is an attractive and noninvasive option for diagnosis. The objectives were to determine the performance of comparison with NPS detecting SARS‐CoV‐2 compare optimized home brew reverse‐transcription polymerase chain reaction (RT‐PCR) a commercial RT‐PCR. Paired specimens prospectively collected tested by RT‐PCR from patients presenting...
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the main target for antiviral and vaccine development. Despite its relevance, e information is scarse about evolutionary traces. aim this study was to investigate diversification patterns each clade SARS-CoV-2 through different approaches. Two thousand one hundred sequences representing seven clades were included. Patterns genetic diversifications nucleotide rate estimated genomic region. haplotype...
Genetic variations in the interleukin 28B (IL28B) gene have been associated with viral response to PEG-interferon-α/ribavirin (PR) therapy hepatitis C virus (HCV) genotype 1 infected patients from North America, Europe and Asia. The importance of these IL28B variants for Argentine remains unknown.IL28B host genotypes (rs8099917 rs12979860) were determined a population European ancestry. Results analyzed looking their association sustained virologic (SVR) PR compared other baseline hosts'...
Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple carcinomas (BCC), mainly caused PTCH1 gene mutations. Our current study aimed to establish (1) germinal and somatic mutational status, (2) component Hedgehog (HH) pathway targets expression patterns, (3) profile variations according the genetic background in BCC normal surrounding skin (NSS). We collected 23 blood 20 patient samples analyzed using bidirectional sequencing multiplex...
Abstract Background & Aims HBV infection exhibits geographical variation in its distribution South America. While rates are low central Argentina, the north‐western region intermediate rates. Unfortunately, reasons that could explain this difference still unknown. Methods A total of 1440 Argentines were recruited and grouped into patients, ‐resolved individuals healthy controls. Genetic ancestry was assessed by analysis biparental lineages autosomal typing. SNP s HLA ‐ DPA 1 (rs3077),...
Hepatitis E virus (HEV) is an emergent that causes acute hepatitis in immunocompetent hosts and chronic immunocompromised ones. In Latin America, the main circulating genotype (GT) 3, which usually of zoonotic origin. Diagnosis seroprevalence studies mainly rely on detection specific antibodies. There are scarce data HEV infection America due to lack awareness circulation. Furthermore, some countries, like Argentina, testing not included routine assays. order provide with tools deepen...
Introduction. Liver disease related to chronic viral hepatitis is a major cause of morbidity and mortality in renal transplant patients. There no agreement upon the influence B (HBV) C (HCV) infection patient graft survival. Aims. The aim study was evaluate HBV HCV on short long term survival, patients transplanted at our institution. Materials methods. We evaluated antiHCV HBsAg status (positive vs. negative); sex; age (> 49 years < transplantation); time dialysis 3 years); acute rejection;...
To determine clinical and virologic characteristics of pandemic (H1N1) 2009 in Buenos Aires, Argentina, we conducted real-time reverse transcription-PCR on samples from patients with influenza-like illness, June 11-30, 2009. Of 513 tested, 54% were positive for influenza virus subtype H1N1. Infection rate was lowest >or=60 years age.
Summary The massive implementation of the vaccine and antiviral agents against hepatitis B virus ( HBV ), targeting envelope viral polymerase genes, induces a selection pressure that might lead to emergence variants impair effectiveness vaccine, diagnostic methods therapy. aim this study was evaluate prevalence escape mutants VEM s), failure DFM s) treatment resistance ARM among individuals from Buenos Aires, Argentina. surface antigen sequences obtained serum samples 530 ‐infected were...
Serology is the preferred method to confirm a Chagas disease diagnosis and screen blood donors. A battery of assays often required due limited accuracy single assays. The Elecsys assay newly developed, double-antigen sandwich for use on cobas e immunoassay analyzers, intended identify individuals infected with Trypanosoma cruzi, screening. performance was evaluated in comparison those other widely used T. cruzi antibody assays, at multiple sites (Europe/Latin America). Relative sensitivity...
Abstract Direct acting antiviral (DAA) therapy against hepatitis C virus (HCV) increases sustained virologic response rates. Nevertheless, drug resistance has occasionally been associated with failure to DAA. However, the information about prevalence of NS5A and NS5B resistance‐associated substitutions (RASs) in Argentina is very scarce. In this study, we determine resistances treatment Argentinean DAA treatment‐naïve patients chronically infected genotype 1 (HCV‐1). retrospective...
Background. Bacterial infections are frequent complications in patients with cirrhosis. Since they associated poor outcomes, antibiotics frequently over-prescribed. Surrogate markers of bacterial infections, like procalcitonin, needed to better discriminate between infected and not patients. Aims. To evaluated the diagnostic accuracy an ultra-sensitive procalcitonin assay for diagnosis Material methods. In a single-center prospective study, we determined basal levels 106 episodes admissions...
Hepatitis E virus (HEV) is the main cause of enteric acute viral hepatitis worldwide. In this epidemiological framework, it has become a threat to blood safety and relevant issue for transfusions. However, there paucity data regarding prevalence HEV infection. The aim study was determine seroprevalence in donors from different regions Argentina.Serum samples 391 individuals attending five donor centers located Argentina were analyzed anti-HEV IgG IgM.Overall, detected 44 out (11.3%) samples....
Background The estimated prevalence of HCV infection in Argentina is around 2%. However, higher rates have been described population studies small urban and rural communities. aim this work was to compare the origin diversification HCV-1b samples from two different epidemiological scenarios: Buenos Aires, a large cosmopolitan city, O'Brien, town with high infection. Patients Methods E1/E2 NS5B regions viral genome 83 patients infected were sequenced. Phylogenetic analysis Bayesian Coalescent...
Background Management of the coronavirus disease 2019 (COVID-19) pandemic caused by a novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requires rapid and simple methods to detect COVID-19 patients identify potential infectors. This study aimed evaluate utility point-of-care (PoC) antigen diagnostic test (Ag-RDT) in these settings. Patients Individuals who consecutively presented for SARS-CoV-2 testing at tertiary care center Buenos Aires, Argentina, underwent PoC Ag-RDT...
Introduction.The COVID-19 pandemic has brought to light the need for rapid diagnostic tests.The gold standard test is reverse transcription-polymerase chain reaction (RT-PCR).RT-PCR requires equipment and trained personnel, results may take a long waiting time.The BD Veritor® System chromatographic method used detection of severe acute respiratory syndrome coronavirus 2 antigen in symptomatic individuals.The primary objective this study assess sensitivity specificity (AT) compared RT-PCR...