A5075709462- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Diet and metabolism studies
- Advanced Radiotherapy Techniques
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Hepatitis Viruses Studies and Epidemiology
- Advances in Oncology and Radiotherapy
- Genetic Associations and Epidemiology
- Bariatric Surgery and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Economic and Financial Impacts of Cancer
- Liver Disease and Transplantation
- Medical Imaging Techniques and Applications
- Animal Virus Infections Studies
- T-cell and Retrovirus Studies
- Forensic and Genetic Research
- Healthcare Operations and Scheduling Optimization
Hospital Italiano de Buenos Aires
2012-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2014-2024
Instituto Universitario Hospital Italiano
2016-2024
Centro Científico Tecnológico - San Juan
2014-2023
Centro Científico Tecnológico - Tucumán
2020
Universitair Ziekenhuis Brussel
2019
Peking University Cancer Hospital
2016
Peking University
2016
National Research Council
2014
Universidad del Salvador
2014
The global burden of chronic liver disease is rising. Besides environmental, behavioral, viral and metabolic factors, genetic polymorphisms in patatin-like phospholipase-3 (PNPLA3) vitamin D receptor (VDR) genes have been related to the development progression towards cancer. Although their prevalence differs remarkably among ethnic groups, frequency these South American populations -whose background highly admixed- has poorly studied. Hence, aim this study was characterize association with...
Unmet needs exist in metabolic dysfunction-associated steatotic liver disease (MASLD) risk stratification. Our ability to identify patients with MASLD advanced fibrosis and at higher for adverse outcomes is still limited. Incorporating novel biomarkers could represent a meaningful improvement current predictors. With this aim, omics technologies have revolutionized the process of biomarker discovery over past decades. While research field thriving, much publication has been haphazard, often...
ABSTRACT Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A mutant antibodies. Both carried unusual L209V substitution within HBsAg.
This study aimed to assess the prevalence of natural resistance-associated substitutions (RASs) NS3, NS5A and NS5B inhibitors in 86 genotype 1 Hepatitis C Virus (HCV)-infected patients from Buenos Aires, Argentina, determine their effect on therapy outcome. Additionally, virological, clinical host genetic factors were explored as predictors presence baseline RASs. NS3 RASs (39.2%) more prevalent than (25%) (8.9%). In three regions, frequencies significantly higher HCV-1b HCV-1a. The Y93H,...
The COVID-19 pandemic poses a great challenge to global public health. extraordinary daily use of household disinfectants and cleaning products, social distancing the loss everyday situations that allow contact between individuals, have direct impact on transfer microorganisms within population. Together, these changes, in addition those occur eating habits, can affect composition diversity gut microbiota. A two-time point analysis fecal microbiota 23 Metropolitan Buenos Aires (BA)...
Interactions between communities of the gut microbiome and with host could affect onset progression metabolic associated fatty liver disease (MAFLD), can be useful as new diagnostic prognostic biomarkers. In this study, we performed a multi-omics approach to unravel signatures from 32 biopsy-proven patients (10 simple steatosis -SS- 22 steatohepatitis -SH-) 19 healthy volunteers (HV). Human microbial transcripts were differentially identified groups (MAFLD vs. HV/SH SS), analyzed for...
Abstract Background & Aims HBV infection exhibits geographical variation in its distribution South America. While rates are low central Argentina, the north‐western region intermediate rates. Unfortunately, reasons that could explain this difference still unknown. Methods A total of 1440 Argentines were recruited and grouped into patients, ‐resolved individuals healthy controls. Genetic ancestry was assessed by analysis biparental lineages autosomal typing. SNP s HLA ‐ DPA 1 (rs3077),...
Previous studies have revealed that hepatitis B virus (HBV)/D and HBV/F predominate among blood donors from Buenos Aires, Argentina. In the present study, samples two high-risk groups were analysed: 160 corresponding to street- hospital-recruited injecting drug users [81.2% showing 'anti-hepatitis core antigen (anti-HBc) only' serological pattern] 20 surface (HBsAg)(+)/anti-HBc(+) men who sex with men. HBV genotypes assigned by polymerase chain reaction amplification followed restriction...
Genomic heterogeneity and quasispecies composition of GB virus C (GBV-C) within plasma lymphocyte subsets in a naturally infected blood donor were investigated. For this purpose, fragments from the 5′ untranslated region (5′ UTR) E2 gene recovered plasma, B T lymphocytes, cloned sequenced. A total 63 clones was analysed: 95.2 % them (n=60) – obtained cells assigned to genotype 2b, while only three derived corresponded genotyope 3. The G215A transition present 90.9 but absent remaining cell...
Introduction Little is known about hepatitis E virus (HEV) infection in patients with cirrhosis. The aim of the present study was to describe frequency HEV and associated risk factors cirrhosis from Argentina. Materials methods We evaluated seroprevalence (IgG anti-HEV) acute infections (IgM RNA) (n = 140) vs. healthy controls 300). Additionally, we compared same outcomes individuals alcohol-related 43) alcohol use disorder (without cirrhosis, n 72). Results overall cohort subjects 25%...
Hepatitis C virus (HCV) represents a major worldwide public health problem. The search for the key molecular biomarkers that may provide insight on basis of differences in disease progression, severity, and response to therapy is crucial understanding natural history HCV, estimating burden infection developing preventive interventions. Initially, epidemiology studies have focused studying viral genetic diversity (genotypes, variants, specific nucleotide amino acid substitutions). However,...
The prevalence of HHV-8 infection varies widely in South American populations, displaying geographical variations its distribution. heterogeneous genetic contributions provided by the transatlantic parental populations that modified Native genomes may explain this epidemiological observation. Aiming to determine genome among healthy blood donors and potential association with ancestry, 772 individuals were screened a highly sensitive PCR protocol ancestry was assessed 414 samples. DNA...
AIM:To evaluate pre-treatment factors associated with sustained virological response (SVR) in patients hepatitis C virus (HCV) genotype 3 treated peginterferon and ribavirin (RBV). METHODS:We retrospectively analyzed treatment naive, mono-infected HCV RBV.Exclusion criteria included presence of other liver disease, alcohol consumption African American or Asian ethnicity.The variables
In order to determine the human pegivirus (HPgV) genotypic diversity in Argentina taking into account potential contribution of migration from neighboring countries, samples 130 Argentine injecting drug users, 116 Argentine- and 50 immigrant-pregnant women were analyzed. HPgV RNA prevalence among immunodeficiency virus (HIV)-positive users was similar HIV-positive pregnant women, as case when comparing HIV-negative (P > 0.05). genotype 2 (HPgV/2) prevalent both contrast HPgV/3 observed Latin...
Summary. Prevalence rates of hepatocellular carcinoma (HCC)‐associated hepatitis B virus (HBV) pre‐S mutants among most genotypes are still lacking. In this study, viral (sub)genotypes 70 Argentine nucleotide sequences (33 newly obtained) were determined by phylogenetic analysis, and the presence such was assessed in American continent for first time. Nucleotide substitutions pre‐S2 start codon observed 10% HBV/A2 sequences. Ten per cent 12.5% HBV/F1b – but none HBV/F4 exhibited a deletion...
_____________________________________________________________________________________________________equally spaced beams with total of 35 segments.Step-andshoot IMRT minimum segment area 5x5 cm and 10 monitor units per was used in each plan.Dvh Energy plans were normalized such that 95% the propagated PTV for phase received prescription dose.Once achieved, doses to OARs, as spinal cord, heart, esophagus, healthy lungs iteratively lowered until standard deviation dose across plan became less...
The functional dynamics of the gut microbiome and its interactions with human transcriptome represent a niche for non-invasive biomarkers to risk-stratify MAFLD. This study aimed identify transcriptomic signatures associated MAFLD in Argentina. Stool samples, diet, demographic clinical data were obtained from 33 biopsy-proven patients (12 simple steatosis -SS- 21 steatohepatitis -SH-) 19 healthy volunteers (HV). RNA-seq was performed NovaSeq6000®. Data analyzed Maaslin2-v1.2.0,...