A5011107249- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Inflammatory Bowel Disease
- Diabetes Management and Research
- Lipid metabolism and disorders
- Botanical Research and Applications
- Lichen and fungal ecology
- Digestive system and related health
- Arsenic contamination and mitigation
- Allergic Rhinitis and Sensitization
- Bariatric Surgery and Outcomes
- Celiac Disease Research and Management
- Trace Elements in Health
- Regulation of Appetite and Obesity
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
National University of Luján
2017-2025
Centro Científico Tecnológico - San Juan
2020-2024
Instituto Universitario de Ciencias de la Salud - Fundación Héctor A. Barceló
2017-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2023
Favaloro Foundation
2019
University of Buenos Aires
2009-2015
Institute of Astronomy and Space Physics
2012-2015
National University of La Rioja
2014
Bernardino Rivadavia Natural Sciences Museum
2014
ABSTRACT Breast cancer is the leading cause of deaths in women worldwide, with about 20,000 cases annually Argentina. While age, diet, and genetics are known risk factors, most breast have unknown causes, necessitating discovery new factors. The aim this study was analysis prognostic relevance oncobiome Argentinean patients. Sequencing V4 region 16S rRNA gene performed on 34 primary tumor samples, using bioinformatic statistical analyses to identify bacteria hypothetical pathways. Each...
The Metabolic Syndrome (MetS) is a cluster of cardiometabolic risk factors, usually accompanied by the presence insulin resistance (IR) and systemic subclinical inflammation state. Metabolically healthy obese (MHO) individuals seem to be protected against complications. aim this work was characterize phenotypically low-grade IR in MHO comparison with MetS control non obese. We studied two different populations: 940 from general population Buenos Aires 518 Venado Tuerto; grouped three groups:...
The COVID-19 pandemic poses a great challenge to global public health. extraordinary daily use of household disinfectants and cleaning products, social distancing the loss everyday situations that allow contact between individuals, have direct impact on transfer microorganisms within population. Together, these changes, in addition those occur eating habits, can affect composition diversity gut microbiota. A two-time point analysis fecal microbiota 23 Metropolitan Buenos Aires (BA)...
Interactions between communities of the gut microbiome and with host could affect onset progression metabolic associated fatty liver disease (MAFLD), can be useful as new diagnostic prognostic biomarkers. In this study, we performed a multi-omics approach to unravel signatures from 32 biopsy-proven patients (10 simple steatosis -SS- 22 steatohepatitis -SH-) 19 healthy volunteers (HV). Human microbial transcripts were differentially identified groups (MAFLD vs. HV/SH SS), analyzed for...
Disturbances in leptin and insulin signaling pathways are related to obesity metabolic syndrome (MS) with increased risk of diabetes cardiovascular disease. Janus kinase 2 (JAK2) is a tyrosine involved the activation mechanisms that mediate actions. We conducted population cross-sectional study explore association between two common variants JAK2 gene MS traits 724 Argentinean healthy male subjects.
Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key innate immune response activation. We studied two polymorphisms (+3725G/C 11350G/C) 3′ untranslated region (3′UTR) TLR4 gene that may alter its expression their association disorders related to inflammation. cloned 3′UTR into luciferase reporter...
Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction longevity. The insulin receptor (IR) binds IGFs with different affinities triggering cell responses.We showed that IGF-II induces proliferation gene transcription when IR-B is over-expressed. We combined biotinylated ligands streptavidin conjugated quantum dots visible fluorescent proteins to visualize the binding of their...
In order to gain further knowledge of the structure zinc transporter 8 (ZnT8) epitopes, we studied role amino acid at position 325 in antigen and its dimeric conformation for autoantibodies ZnT8 (ZnT8A) recognition.For this purpose, several C-terminal domain variants were designed: monomer carrying Arg325 or Trp325, homo-dimers ZnT8-Arg-Arg325 ZnT8-Trp-Trp325, hetero-dimer ZnT8-Arg-Trp325. Two groups Argentinian diabetic patients subjected analysis using [(35)S]-ZnT8 by radioligand binding...
In recent years, the field of immunology has been revolutionized by growing understanding fundamental role microbiota in immune system function. The evolved to maintain a symbiotic relationship with these microbes. aim our study was know depth uncharacterized metagenome Buenos Aires (BA) city population and its metropolitan area, being second most populated agglomeration southern hemisphere. For this purpose, we evaluated 30 individuals (age: 35.23 ± 8.26 years BMI: 23.91 3.4 kg/m2), from...
Six pieces of fossil wood from the late Miocene Northwestern Argentina (Salicas Formation) are described.They all assigned to Prosopisinoxylon anciborae Martínez based on presence following diagnostic characters: vessels two distinct diameter classes, simple perforation plates, vestured pits, abundant axial parenchyma and wide rays.Signifi cant anatomical variation exists among specimens but they regarded as a single taxonomic unit because usually gradual transition is observed most variable...
Background: Latent autoimmune diabetes in adults (LADA) is determined by both a noninsulin‐dependent clinical presentation and an pathogenic process. Glutamic acid decarboxylase antibody (GADA) constitutes the most important marker, although IA‐2A ZnT8A also define LADA presentation. Type 2 mellitus (T2DM) prevalent type particularly over 65 years old. Studies about autoimmunity this age group are scarce. Objective: The aim of work was to determine whether three autoantibodies for were...
Pollen grains of Celtis tala (Celtidaceae), Phytolacca dioica (Phytolaccaceae), Schinopsis balansae (Anacardiaceae) and Solidago chilensis (Asteraceae) are examined with light scanning electron microscopy, described, illustrated. These four unrelated species native to southern South America considered an important source skin prick allergy tests. Most relevant pollen characters compared those their closest relatives. (3-, 4-, or 5- porate, verrucate) shares the africana type in lacking a...
Inflammatory bowel disease (IBD) is the most common form of intestinal inflammation associated with a dysregulated immune system response to commensal microbiota in genetically susceptible host. IBD includes ulcerative colitis (UC) and Crohn's (CD), both which are remarkably heterogeneous their clinical presentation treatment. This translates into notable diagnostic challenge, especially underdeveloped countries where on rise access diagnosis or treatment not always accessible for chronic...
The functional dynamics of the gut microbiome and its interactions with human transcriptome represent a niche for non-invasive biomarkers to risk-stratify MAFLD. This study aimed identify transcriptomic signatures associated MAFLD in Argentina. Stool samples, diet, demographic clinical data were obtained from 33 biopsy-proven patients (12 simple steatosis -SS- 21 steatohepatitis -SH-) 19 healthy volunteers (HV). RNA-seq was performed NovaSeq6000®. Data analyzed Maaslin2-v1.2.0,...
ABSTRACT Background and Aims Non-invasive biomarkers are urgently needed to identify patients with non-alcoholic fatty liver disease (NAFLD) especially those at risk of progression. This is particularly true in high prevalence areas such as Latin America. The gut microbiome intestinal permeability may play a role the developing NAFLD NASH, but mechanism by which microbiota composition disruption (or dysbiosis) affect progression still unknown. Targeted metabolomics powerful technology for...
Introduction Insulin and proinsulin autoantibodies (IAA/PAA) are usually the first markers to appear in patients with type 1 Diabetes Mellitus (T1DM) their prevalence ranges from 10 60% child-adolescent population. The reference method for IAA/PAA detection is Radioligand Binding Assay (RBA), a highly specific sensitive technique, but expensive polluting. aim of this work was develop novel flow cytometric microsphere-based immunoassay (FloCMIA) PAA detection, employing recombinant human...
Fungi, archaea and protozoa are the least known members of gut microbiome, but they could represent a niche for biomarkers discovery to risk-stratify MAFLD patients. This study aimed identify metatranscriptomic signatures in patients from Argentina. Stool samples, diet, demographic clinical data were obtained 33 biopsy-proven (12 simple steatosis (SS) / 21 steatohepatitis (SH)) 19 healthy volunteers (HV). PNPLA3 rs738409 SNP was genotyped. RNA-seq performed NovaSeq6000®. Data analyzed with...