A5002356507- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Paraoxonase enzyme and polymorphisms
- Lipid metabolism and disorders
- Pituitary Gland Disorders and Treatments
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Growth Hormone and Insulin-like Growth Factors
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Systemic Lupus Erythematosus Research
- Antioxidant Activity and Oxidative Stress
- Iron Metabolism and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Hemoglobinopathies and Related Disorders
- Vitamin C and Antioxidants Research
- Cardiac Valve Diseases and Treatments
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
University of Buenos Aires
2009-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2009-2025
Inserm
2014-2016
Sorbonne Université
2016
Center for Excellence in Molecular Cell Science
2014
Chinese Academy of Sciences
2014
Shanghai Institutes for Biological Sciences
2014
El Hospital General de Agudos Carlos G. Durand
2011
Institute of Astronomy and Space Physics
2008
Ministerio de Salud
2007
Mediator complex is a molecular hub integrating signaling, transcription factors, and RNA polymerase II (RNAPII) machinery. MED23 involved in adipogenesis smooth muscle cell differentiation, suggesting its role energy homeostasis. Here, through the generation analysis of liver-specific Med23-knockout mouse, we found that liver Med23 deletion improved glucose lipid metabolism, as well insulin responsiveness, prevented diet-induced obesity. Remarkably, acute hepatic knockdown db/db mice...
Eur J Clin Invest 2011; 41 (5): 479–486 Introduction Iron overload (IO) is defined as an increase in storage iron, regardless of the presence or absence tissue damage. Whether increased iron stores are involved pathogenesis cardiovascular disease remains controversial. Objectives To study insulin resistance markers, lipoprotein profile, activities anti and prooxidant enzymes cholesteryl ester transfer protein (CETP) patients with IO. Methods Twenty male IO were compared 20 sex- age-matched...
In acromegalic patients, cardiovascular and metabolic comorbidities contribute to enhance mortality. Available data on the lipoprotein profile of these patients are controversial. Our aim was characterize emergent biomarkers disease in active comparison with sex- age-matched healthy controls.Eighteen acromegaly 18 controls were studied.Glucose levels, hormonal status, C reactive protein (CRP) evaluated by standardized methods. Cholesteryl ester transfer (CETP) lipoprotein-associated...
Acromegaly is characterized by GH excess and insulin resistance. It not known which of these disorders responsible for the increased atherogenic risk in patients.To analyse associations homoeostasis model assessment (HOMA) with biomarkers cardiovascular disease to compare above-mentioned variables between patients active acromegaly controls.This open cross-sectional study was conducted at a University Hospital.Twenty-two outpatients were compared sex- age-matched control subjects.Included...
Active acromegaly is associated with increased mortality from cardiovascular causes. Several studies have shown atherogenic risk factors and biomarkers of inflammation atherosclerosis in association growth hormone excess. The aim this study was to evaluate oxidized low density lipoprotein (oxLDL) levels some modulators LDL oxidative modification patients acromegaly.Open transversal study.Fifteen active 15 controls were studied.We evaluated the oxLDL, thiobarbituric acid reactive substances...
Disturbances in leptin and insulin signaling pathways are related to obesity metabolic syndrome (MS) with increased risk of diabetes cardiovascular disease. Janus kinase 2 (JAK2) is a tyrosine involved the activation mechanisms that mediate actions. We conducted population cross-sectional study explore association between two common variants JAK2 gene MS traits 724 Argentinean healthy male subjects.
Low plasma triiodothyronine (T(3)) levels are considered a prognostic predictor of death in heart failure (HF) patients.To study an association between T(3) and several cardiac, neurohormonal, metabolic markers HF.A total 133 ambulatory HF patients (114 males; mean age 63.2 years) with left ventricular ejection fraction <40% were enrolled. TSH, tetraiodothyronine (T(4)) T(3), N-terminal pro-brain natriuretic peptide (NT-proBNP), other cardiac parameters measured. The lowest tertile (group 1)...