A5089939079- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Birth, Development, and Health
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Plasma Diagnostics and Applications
- Cardiovascular Disease and Adiposity
- Trace Elements in Health
- Fatty Acid Research and Health
- Health and Lifestyle Studies
- Lipid metabolism and biosynthesis
- Cellular transport and secretion
- Cardiovascular Health and Disease Prevention
- Dialysis and Renal Disease Management
- Genetics, Bioinformatics, and Biomedical Research
- Astro and Planetary Science
- Natural Products and Biological Research
- Spacecraft and Cryogenic Technologies
- Planetary Science and Exploration
National Heart Lung and Blood Institute
2015-2025
National Institutes of Health
2015-2025
London School of Hygiene & Tropical Medicine
2025
University of Buenos Aires
2010-2019
Instituto de Química y Fisicoquímica Biológicas
2016-2019
Sandia National Laboratories California
2018
Advanced Materials Enterprises (China)
2018
Centro Científico Tecnológico - San Juan
2017
Institute for Atherosclerosis Research
2017
Sandia National Laboratories
2016
Increased small dense low-density lipoprotein-cholesterol (sdLDL-C) is a risk factor for atherosclerotic cardiovascular disease (ASCVD) but typically requires advanced lipid testing. We describe two new equations, first one calculating large buoyant LDL-C (lbLDL-C), based only upon results from the standard panel, and second sdLDL-C.Equations sdLDL-C lbLDL-C were generated with least-squares regression analysis using direct Denka assay as reference (n = 20 171). was assessed risk-enhancer...
Introduction The immune system acts on different metabolic tissues that are implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Leptin and linoleic acid have ability to potentially affect cells, whereas curcumin is a known natural polyphenol with antioxidant anti-inflammatory properties. Aims This study was designed evaluate pro-inflammatory pro-oxidant effects leptin cells from patients NAFLD corroborate modulatory its preventive properties against progression using...
Health professionals are burn out syndrome prone occupational group. In Ethiopia there limited evidences about burnout and work related determinant factors resulting in Burnout syndrome. Therefore, this study aimed to determine the prevalence of associated among health working university hospitals found Sidama region Southern 2023. An institution based multi-center cross-sectional was conducted on 362 three hospital from February 15 30, Study participants were recruited using Simple random...
Background: Current lipid-lowering drugs reduce low-density lipoprotein (LDL) cholesterol by enhancing the LDL receptor (LDLR) pathway and are relatively ineffective in patients with Familial Hypercholesterolemia (FH) due to a dysfunctional LDLR. Angiopoietin-like 3 (ANGPTL3) inhibitors FH through an uncharacterized, LDLR-independent that requires endothelial lipase (EL). Kinetic studies showed ANGPTL3 directly enhanced catabolism; however, EL's role this remains unclear. Here, we aim...
Hepatic lipase is a lipolytic enzyme mostly synthesized and localized at the surface of liver sinusoidal capillaries, which hydrolyses triglycerides phospholipids intermediate density, large low density (LDL) high lipoproteins. activity increased in insulin resistant states. Non-alcoholic fatty disease (NAFLD) characterized by resistance. However, present, no data are available regarding behaviour hepatic with regard to degree steatosis. Our aim was evaluate NAFLD patients its relationship...
Background: Qualitative lipoprotein changes, such as an increase in fasting remnants, are reported subclinical hypothyroidism (SCH). It was hypothesized that changes due to reduced hepatic lipase (HL) activity SCH: HL is enzyme regulated by thyroid hormones, and involved the degradation of triglyceride (TG)-rich remnants. This study aimed quantify remnant-like lipoproteins (RLP), small dense LDL (sdLDL), women with SCH, assess these parameters after levothyroxine replacement therapy....
Objective— To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma subjects with metabolic syndrome (MS)/obesity their relationship atherogenic antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein (LPL) HL as triglyceride (TG)-hydrolyses complete analyses SN1 lipolytic enzymes same patient. Approach Results— Plasma EL, HL, LPL activities were evaluated 59 patients MS 36 controls. A trend toward higher EL was observed MS. increased...
ApoB-100 is a member of large lipid transfer protein superfamily and one the main apolipoproteins found on low-density lipoprotein (LDL) very (VLDL) particles. Despite its clinical significance for development cardiovascular disease, there limited information apoB-100 structure. We have developed novel method based “divide conquer” algorithm, using PSIPRED software, by dividing into five subunits 11 domains. Models each domain were prepared I-TASSER, DEMO, RoseTTAFold, Phyre2, MODELLER....
The close association between nonalcoholic fatty liver and insulin resistance is now widely recognized. While the former characterized by excessive intrahepatic triglyceride accumulation, latter induces overproduction of very-low-density lipoprotein (VLDL) particles. It has not been well elucidated whether these apparently opposite mechanisms impact on VLDL characteristics or not. aim present study was to evaluate secretion features resulting from in rats fed a sucrose-rich diet (SRD, i.e....
Could supplementation with n-3, n-6 and n-9 fatty acids prevent atherogenic alterations of VLDL produced in insulin-resistance?
A significant proportion of patients with elevated LDL and a clinical presentation familial hypercholesterolemia do not carry known genetic mutations associated hypercholesterolemia, such as defects in the receptor. To identify new genes involved cellular uptake LDL, we developed novel whole-genome clustered regularly interspaced short palindromic repeat-Cas9 KO screen HepG2 cells. We identified transgelin (TAGLN), an actin-binding protein, potentially gene endocytosis. In silico validation...
Abstract Background Matrix metalloproteinases ( MMP s), especially ‐2 and ‐9, have been identified in atherosclerotic plaques directly associated with plaque remodelling vulnerability. Cardiovascular disease (CVD) is related to insulin resistance IR ) obesity, characterized by changes plasma levels of inflammatory markers, such as adiponectin C‐reactive protein CRP ). Our aim was evaluate the impact both proteins on ‐9 behaviour individuals . Materials methods Plasma activity, hs‐...
We sought to explore biomarkers of coronary atherosclerosis in an unbiased fashion.We analyzed 665 patients (mean ± SD age, 56 11 years; 47% male) from the GLOBAL clinical study (NCT01738828). Cases were defined by presence any discernable atherosclerotic plaque based on comprehensive cardiac computed tomography (CT). De novo Bayesian networks built out 37,000 molecular measurements and 99 conventional per patient examined potential causality specific biomarkers.Most highly ranked gradient...