A5064513265- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Genomics and Rare Diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Adolescent Sexual and Reproductive Health
- Cancer Genomics and Diagnostics
- Pregnancy and Medication Impact
- Family Dynamics and Relationships
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience of respiration and sleep
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Family Support in Illness
- Child and Adolescent Health
- Cancer survivorship and care
- Melanoma and MAPK Pathways
- Substance Abuse Treatment and Outcomes
- Palliative Care and End-of-Life Issues
- Cutaneous Melanoma Detection and Management
- Islamic Finance and Banking Studies
- Viral Infections and Immunology Research
- RNA modifications and cancer
- Demographic Trends and Gender Preferences
- Youth Development and Social Support
- Restraint-Related Deaths
Rady Children's Hospital-San Diego
2023-2025
University of Washington
2024
Children’s Institute
2023-2024
Johns Hopkins Medicine
2021-2023
University of California, San Francisco
2023
University of California, San Diego
2018-2023
Johns Hopkins University
2021-2023
University of California System
2023
University of Pennsylvania
2019
Tufts Medical Center
2016
Understanding the causes of infant mortality shapes public health, surveillance, and research investments. However, association single-locus (mendelian) genetic diseases with is poorly understood.
To survey an international sample of providers to determine their current practices for the prevention, screening, and treatment congenital heart block (CHB) due maternal Ro/SSA antibodies.A was designed by organizing committee 9th International Conference Reproduction, Pregnancy Rheumatic Diseases. It sent attendants conference authors recent publications or abstracts at ACR 2012, 2013 2014 on rheumatic diseases pregnancy.In anti-Ro/SSA positive women, 80% 49 respondents recommended...
Rituximab is a CD20-directed cytolytic antibody used for non-Hodgkin lymphoma, chronic lymphocytic leukaemia and RA, off label JIA, multiple sclerosis lupus. Owing to concerns about infant B cell depletion, the manufacturer recommends avoidance of rituximab throughout pregnancy 12 months before conception. The aim this study was add limited data on outcomes in women with exposure rituximab.Data were obtained from MotherToBaby Pregnancy Studies. Participants enrolled prospectively into...
The Mendelian Phenotype Search Engine (MPSE), a clinical decision support tool using Natural Language Processing and Machine Learning, helped neonatologists expedite decisions to whole genome sequencing (WGS) diagnose patients in the neonatal intensive care unit. After MPSE was introduced, utilization of WGS increased, time ordering decreased, diagnostic yield increased.
Recent studies suggest that the anti‑diabetic drug metformin may reduce risk of cancer and have anti‑proliferative effects for some but not all cancers. In this study, we examined on human retinoblastoma cell proliferation in vitro vivo. Two different lines (Y79, WERI) were treated with xenografts Y79 cells established nu/nu immune‑deficient mice used to assess pharmacological levels Metformin inhibited vitro. Similar other studies, high concentrations (mM) blocked cycle G0‑G1, indicated by...
Many studies of sudden unexpected infant death (SUID) have focused on individual domains risk factors (maternal, infant, and environmental), resulting in limited capture this multifactorial outcome. The objective study was to examine the geographic distribution SUID San Diego County, assess maternal, environmental from a large, administrative research platform.Births California between 2005 2017 were linked hospital discharge summaries files. From retrospective birth cohort, cases identified...
Significance Statement We describe circulating proteins associated with albuminuria in a population of African American Study Kidney Disease and Hypertension CKD (AASK) using the largest proteomic platform to date: nearly 7000 proteins, representing approximately 2000 new targets. Findings were replicated subset general cohort kidney disease (ARIC) Chronic Renal Insufficiency Cohort (CRIC). In cross-sectional analysis, 104 significantly Black group, which 67 77 available ARIC 68 71 CRIC....
The adolescent and young adult (AYA) population is a growing group of survivors, exceeding more than 600,000, at high risk for late effects cancer-directed therapy. While many guidelines exist cancer survivorship care, choosing which to use an AYA survivor challenging, yet vital, ensure comprehensive follow-up care.Survivorship care plans (SCPs), including treatment summaries (TS) plans, were created three clinical vignettes (acute lymphoblastic leukemia, osteosarcoma, Hodgkin lymphoma)....
The Mendelian Phenotype Search Engine (MPSE), a clinical decision support tool using Natural Language Processing and Machine Learning, helped neonatologists expedite decisions to whole genome sequencing (WGS) diagnose patients in the Neonatal Intensive Care Unit. After MPSE was introduced, utilization of WGS increased, time ordering decreased, diagnostic yield increased.
Past research has revealed that having a sister who gave birth as teenager is associated with increases in young people's likelihood of engaging risky sexual behavior. To date, however, no study determined if several sisters were adolescent mothers further raises youths' chances activities.Data collected from 1,510 predominantly Hispanic and black 11-17-year-olds California program for youths have at least one pregnant or parenting sister. Correlational analyses, analyses variance regression...
CONTEXT: The siblings of adolescents who have been pregnant or are parents disproportionately high rates teenage pregnancies and births. California's Adolescent Sibling Pregnancy Prevention Program is targeted at these high‐risk youths. METHODS: An evaluation the program was conducted in 1997–1999 with 1,176 predominantly Hispanic 11–17‐year‐olds had least one sibling an adolescent parent pregnant–731 youths were clients 445 received no systematic services. All participants completed...
The objectives of this study were to describe trends in the prevalence postpartum suicidal behaviors California, 2013-2018, and estimate associations between adverse perinatal outcomes behaviors.
For the last 30 years, pregnancy exposure studies, with varying methodologies, have been mainstay of post-marketing surveillance for new drugs likely to be used by women reproductive age. While they provide valuable data inform use during pregnancy, limitations that render them necessary but not sufficient in supplying timely information patients and prescribers. The Organization Teratology Information Specialists MotherToBaby Pregnancy Studies' collaborative research group operates help...
Abstract Duchenne muscular dystrophy (DMD) is a relatively common, severe, progressive, X-linked muscle disorder caused by pathogenic variation in the dystrophin gene. Affected status can be determined at birth, 3-5 years before symptom onset. As effective corticosteroid and genetic therapies are becoming available for DMD, predictive models of DMD progression needed to guide individualized care patients clinical trials new treatments. We developed multivariable, dynamical model progression,...
147 Background: The AYA population is a growing group of survivors, exceeding more than 600,000 who are at high risk for late effects cancer-directed therapy. While many guidelines exist cancer survivorship care, choosing which to use an survivor challenging, yet essential, ensure comprehensive follow-up care. Methods: Survivorship care plans, including treatment summaries and were created three clinical vignettes (acute lymphoblastic leukemia, osteosarcoma, Hodgkin Lymphoma). Four sets used...
43 Background: The AYA population is a growing group of cancer survivors, currently exceeding 600,000 in the US, with 70,000 new diagnoses each year. These survivors experience deficits general health, mental and functional status. Unfortunately, many are lost to follow-up after completion active therapy. They lack clarity about where go for care why such needed. To further complicate this, have not established primary provider (PCP). Methods: We present model survivorship tailored...
6565 Background: Advances in quality of life (QOL) measurement, including improved precision and brevity, greatly enhance the incorporation QOL assessment at point-of-care. In this study we report novel PROMIS Global Health Scale to AYA oncology population. Methods: Patients 18-39 years old, who presented for routine care Tufts Medical Center’s Reid R. Sacco Cancer Program The University Chicago’s Oncology Program/Childhood Survivor Center were invited complete 10-question upon check-in....
CONTEXT: The siblings of adolescents who have been pregnant or are parents disproportionately high rates teenage pregnancies and births. California's Adolescent Sibling Pregnancy Prevention Program is targeted at these high-risk youths. METHODS: An evaluation the program was conducted in 1997–1999 with 1,176 predominantly Hispanic 11–17-year-olds had least one sibling an adolescent parent pregnant–731 youths were clients 445 received no systematic services. All participants completed...