A5016475330- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Magnolia and Illicium research
- Sesquiterpenes and Asteraceae Studies
- Bioactive Natural Diterpenoids Research
- Bioactive natural compounds
- Chromatography in Natural Products
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Pharmacological Effects of Natural Compounds
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
- Cell death mechanisms and regulation
- Phytochemistry and Bioactivity Studies
- Traditional Chinese Medicine Analysis
- Synthesis and bioactivity of alkaloids
- melanin and skin pigmentation
- Microbial Natural Products and Biosynthesis
- Flavonoids in Medical Research
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
Guangxi Institute of Botany
2013-2025
Chinese Academy of Sciences
2017-2024
Guangxi Normal University
2013-2021
Guangxi University
2021
Ministry of Education of the People's Republic of China
2016
Beijing University of Chinese Medicine
2009
From the tubers of Stephania kwangsiensis, two undescribed alkaloids (7 R, 14S)-thaicanine α-N-oxide (1) and (6S, 6aS, 7 R)-sukhodianine (2) were isolated, adding 14 which had been reported earlier. The structural definition 1-16 was achieved by analysing mass spectrum nuclear magnetic resonance data, as well comparing calculated ECD spectra with experimental ones. N-O-Dimethylthaicanine (12) polycarpine (14) displayed favourable α-glucosidase inhibitory activities in vitro IC50 values 3.001...
Four new dammarane triterpenoid saponins cypaliurusides Z1-Z4 (1-4) and eight known analogs (5-12) were isolated from the leaves of Cyclocarya paliurus. The structures compounds determined using a comprehensive analysis 1D 2D NMR HRESIMS data. docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for treatment type-II diabetes obesity), hydrogen bonds, hydrophobic interactions, verifying importance sugar unit. effects isolates on insulin-stimulated...
The roots of Melastoma malabathricum subsp. normale (D. Don) Karst. Mey have been used in traditional ethnic medicine systems China to treat inflammation-triggered ailments, such as trauma, toothache, and fever. Therefore, the aim this study is screen for compounds with anti-inflammatory activity title plant. extract M. was separated using various chromatographic methods, silica gel, ODS C18, MCI Sephadex LH-20 column chromatography, well semi-preparative HPLC. One new complex tannin, named...
A pair of enantiomers and a 2,3-dihydro-1H-indene epimers, rac-indidene (rac-1), indidenes B C (2, 3); four new coumarin glucosides (4–7); known (8–11) were isolated from the bark Streblus indicus (Bur.) Corner. The structures 1–11 defined by physical data analyses, including MS, NMR, single-crystal X-ray diffraction. absolute configurations derivatives via experimental calculated ECD data. rac-Indidene showed inhibitory activity against A549 MCF-7 tumor cells with IC50 values in range 2.2 ±...
The characteristics of high polarity and susceptibility to oxidation in phenolic glycosides increase the difficulty their separation from natural products. In present study, two new with similar structures were isolated Castanopsis chinensis Hance using a combination multistep CC high-speed countercurrent chromatography. Preliminary target fractions was carried out by Sephadex LH-20 chromatography (100–0% EtOH H2O). High-speed an optimized solvent system N-Hexane/Ethyl acetate/Methanol/Water...
A new compound, illiciumflavane acid (1), along with 13 known compounds (2–14), were isolated from the fruits of Illicium verum Hook. F. Their structures elucidated through various spectroscopic methods, including 1D NMR (1H NMR, 13C NMR), 2D (HMQC, HMBC and NOESY) HRMS. The stereochemistry at chiral centres was determined using CD spectrum as well analyses coupling constants optical rotation data. Cytotoxicity evaluation four showed that (E)-1,2-bis(4-methoxyphenyl)ethene exhibited...
Two new coumarins 7-O-(6-O-(5-O-3,4,5-tri-methoxycinnamate-β-d-apiofuranosyl-β-d-glucopyranosyl)-6-methoxy coumarin (1) and 7-O-(6-O-(4-(2-hydroxy-1-hydroxymethyl-ethoxy)-3-methoxy-cinnamyl)-β-d-glucopyranosyl)-6-methoxy (2), along with 10 known metabolites, were isolated from the bark of Streblus indicus, their structures identified by comparison experimental published spectroscopic data. (S)-marmesinin (6) scoparone (7) exhibited moderate antimicrobial activity in vitro against...
Free radical scavengers or antioxidants are currently forged as the drug candidates to counter many diseases, such drug-associated toxicity, inflammation, atherogenesis and aging in aerobic organisms [1][2][3] .Thus significance of free radicals pathogenesis various diseases has attracted considerable interest.Minor dietary compositions have been considerably deemed combat ill effects radicals.In addition, since that what may be learn from natural plants could overcome toxicity problem...
Three new compounds (6S,9S)-6′-galloyl-roseoside (1), purpurogallin ethyl carboxylate (2), and tibetana A (3) were isolated from 80% methanol extract of the leaves Castanopsis Hance. Their structures elucidated based on comprehensive spectroscopic methods chemical data, including optical rotation, UV, MS, 1 D 2 NMR spectra. Compounds 3 evaluated for their α-glucosidase inhibitory activity, pancreatic lipase tyrosinase activity.
Castanopsis fordii Hance 1884 is a typical evergreen broad-leaved forest plant in the south subtropical and middle regions of China. It has high utilization value wood production soil erosion protection. Here, we first reported characterized complete chloroplast (cp) genome sequence C. based on Illumina paired-end sequencing data. The cp was 160,853 base pairs (bp) length which contained two inverted repeats (IRs) 25,699 bp separated by large single-copy (LSC) small single copy (SSC) 90,474...
Polyphenols, widely distributed in the genus
As a part of our systematic study on Castanopsis genus (Fagaceae), one new triterpene hydrolysable tannin (1) and two phenol glucosides (2 3) were isolated from the leaves eyrei (Champ. ex Benth.) Hutch. Compound 1 was identified as hexahydroxydiphenoyl (HHDP) ester. This type compounds has only been genus. The structures 1-3 elucidated by combination spectroscopic analysis (MS, D 2 NMR) chemical evidence.
In a continuing phytochemical investigation of the Castanopsis species (Fagaceae), two new galloyl glucosides, 5-O-β-D-(6'-O-galloyl)glucopyranosyl pyran-2-one (1) and 4-hydroxymethyl-2-methoxyphenol 1-O-β-D-(6'-O-galloyl)glucoside (2), were isolated from ethanolic extract bark fargesii, together with six known compounds.Their structures elucidated on basis spectroscopic data analysis.The oxygen radical absorbance capacity (ORAC) values all compounds measured compound...
Phytochemical investigation of the Leaves Castanopsis eyrei led to isolation two new natural truxinate derivatives and a phenyldilactone. The structures compounds were determined by spectroscopic methods chemical evidence as 3,3',4,4'-tetrahydroxy-β-truxillic acid (1), 3,3',4,4'-tetrahydroxy-δ-truxillic (2), 3'-hydroxymaysedilactone A (3). Establishment Caenorhabditis elegans lipid metabolism model using GFP mCherry fluorescently labeled droplets screen compound 3 for its activity in...
Abstract Three ursolic acid-piperazine-dithiocarbamate ruthenium(II) polypyridyl complexes Ru1–Ru3 were designed and synthesized for evaluating antitumor activity. All the exhibited high in vitro cytotoxicity against MGC-803, T24, HepG2, CNE2, MDA-MB-231, MCF-7, A549, A549/DDP cell lines. Ru1, Ru2, Ru3 11, 8 10 times, respectively, more active than cisplatin A549/DDP. An vivo study on MGC-803 xenograft mouse models demonstrated that representative Ru2 an effective inhibitory effect tumor...