A5062289502- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cervical Cancer and HPV Research
- Cancer Mechanisms and Therapy
- Jewish and Middle Eastern Studies
- Ovarian cancer diagnosis and treatment
- Multiple Myeloma Research and Treatments
- COVID-19 and healthcare impacts
- Genomic variations and chromosomal abnormalities
- Jewish Identity and Society
- Lymphoma Diagnosis and Treatment
- Innovative Teaching Methods
- Advanced biosensing and bioanalysis techniques
- Inflammatory Biomarkers in Disease Prognosis
- AI in cancer detection
- Surgical site infection prevention
- Pharmacological Effects and Toxicity Studies
- Indian History and Philosophy
- PARP inhibition in cancer therapy
- Media, Gender, and Advertising
- American Jewish Fiction Analysis
- Infectious Encephalopathies and Encephalitis
King George's Medical University
2012-2025
Creative Commons
2023
University of Münster
2003-2010
University Hospital Münster
2006
Vanderbilt University
2003
Friedrich Schiller University Jena
2003
Osaka University
2003
Hospital for Sick Children
2001
Abstract Based on the principle of dual prediction by segment hydrophobicity and nonpolar phase helicity, in concert with imposed threshold values these two parameters, we developed automated program TM Finder that can successfully locate most transmembrane (TM) segments proteins. The uses results experiments a series host‐guest mimic peptides prototypic sequence KK AAA X AAAAA AAWAA KKKK‐amide (where = each 20 commonly occurring amino acids) through which an HPLC‐derived hydropathy scale,...
Epigenetic changes play an important role in leukemia pathogenesis. DNA methylation is among the most common alterations leukemia. The potential of as a biomarker unknown. In addition, lack molecular markers precludes minimal residual disease (MRD) estimation for patients with hematologic malignancies. We analyzed aberrant promoter MRD acute leukemias. Quantitative real-time PCR methods bisulfite-modified were established to quantify based on estrogen receptor alpha (ERalpha) and/or...
<title>Abstract</title> <bold>Introduction:</bold>Active learning techniques like Case-Based Learning (CBL) and Jigsaw are effective small group methods. They promote higher-order cognitive skills improved collaboration. Both compared to didactic lectures. The study aims evaluate a comprehensive comparison of these regarding their impact on knowledge retention, the development clinical reasoning, overall student satisfaction. <bold>Material & Methods:</bold> Sixty postgraduate medical...
Posthumanism has emerged as a crucial conceptual framework in the field of literature. While future remains uncertain, humanity's innate curiosity about its relationship with nature, animals and non-living entities always been core topic discussion. The ethical principles put forth by posthumanism are significant today’s rapidly evolving world, emphasizing interconnectedness all beings, whether or not people acknowledge this bond. Hungry Tide Amitav Ghosh uses theory to critique...
Background and Introduction: Chromosomal abnormality is found in about half of first-trimester abortions. Karyotype the gold standard to detect chromosomal abnormalities. Multiplex ligation-dependent probe amplification (MLPA) offers advantage over karyotype terms lower failure rate, faster turnaround time, much higher resolution than conventional karyotyping be 98% concordant with karyotype.We performed this study look for utility MLPA diagnosing abnormalities abortions.MLPA using...
Important progress has been achieved in the knowledge about pathogenesis of cancer. However, despite these advances, therapeutic strategies are still limited. Leukemias often characterized by specific balanced translocations, with t(8;21) translocation being most frequent chromosomal aberration acute myeloid leukemia (AML). This produces AML1-ETO fusion protein, which binds to AML1 target promoter sequences. Transcriptional repression AML1-dependent genes and associated corepressors...
Introduction: Cardiac disorders complicate approximately 1%–3% of pregnancies and present a real challenge to treating healthcare providers.Maternal mortality may be as high 7% when New York Heart Association (NYHA) Classes III IV patients are combined. In contrast, I II combined yield 0.5%. Similarly, fetal maybe 30% in Class patients, contrast 2% for II. Managing pregnant with complex cardiac disease mandates participation from multidisciplinary team early the pregnancy. Audit misses near...
<h3>Introduction/Background</h3> Every year, 240,000 women are diagnosed with ovarian cancer a five-year survival rate of less than 45%. Majority (85% to 90%) is epithelial in origin. Therefore, both surgery and chemotherapy required for comprehensive disease treatment.Standard includes three weekly carboplatin paclitaxel. Dose dense paclitaxel regimen new approach this showing higher efficacy lesser side effects some trials. <h3>Methodology</h3> It was prospective pilot study conducted over...
Aim: To assess impact of early diagnostic laparoscopy and hysteroscopy in cases primary secondary infertility on fertility outcome.Methodology: This was a prospective study conducted the Department Obstetrics & Gynaecology at KGMU, 175 evaluated by laparoscopy, from January 2018 to December were enrolled.Thorough history examination done.Any positive findings per any therapeutic intervention done noted.Results: Out total 110 (62.8%) infertility, 65 (37.14%) infertility.Majority patients age...
This study traces the fascinating development of witch archetype, from a vilified character to potent representation tenacity and empowerment feminism. It reveals how patriarchal civilizations have deftly exploited social conventions religion subjugate women through an analysis foundational literature such as “Malleus Maleficarum”(1487) “The Witch Cult in Western Europe” (1921). The employs theories gender performativity existential feminism, drawing on profound insights notable feminists...
Background: Surgical site infection (SSI) is most common nosocomial (15%) among surgical patient’s and contributes significantly to morbidity mortality. CDC (2015) provides “bundled intervention for prevention of SSI. The present study was planned evaluate the feasibility usefulness these bundled in reducing SSI our setup. Objectives this effect interventions on gynaecologic surgery.Methods: A total 50 cases undergoing gynecological surgery elective OT included pilot group followed compared...
Sentinel lymph node (SLN) mapping is a standard of care in gynecological cancers but with limited resources and equipment, intraoperative use methylene blue for SLN may be more useful.To authenticate the dye cases early-stage cancers.This pilot study was conducted tertiary teaching hospital.The included 14 cervical, 4 endometrial, 1 vulvar, synchronous cervical-vulvar cancer wherein 21 mappings were done. Four ml injected submucosally cervix cervical endometrial cancer. It around tumor...
Extramedullary disease in acute myeloid leukemia is a known phenomenon with reported incidence of 2.5-9.1 %. However, kidney injury due to direct infiltration malignant cells only 1% cases leukemia. We report case who developed failure at presentation, was diagnosed renal and pancreatic by FDG-PET scan treated successfully hypomethylating agent venetoclax. PET-CT can be non-invasive modality for diagnosing extramedullary monitoring response therapy these cases. Early initiation anti-leukemia...