A5057630618- Blood transfusion and management
- Erythropoietin and Anemia Treatment
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Vaccine Coverage and Hesitancy
- Blood donation and transfusion practices
- Health Policy Implementation Science
- Prenatal Screening and Diagnostics
- Child Nutrition and Water Access
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antimicrobial Resistance in Staphylococcus
- Health and Wellbeing Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Clostridium difficile and Clostridium perfringens research
- Acute Myocardial Infarction Research
- Menstrual Health and Disorders
- Streptococcal Infections and Treatments
University of Pittsburgh
2021-2025
Emory University
2020-2022
London School of Hygiene & Tropical Medicine
2021
University of Arkansas for Medical Sciences
2021
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain. To estimate the efficacy of 4 individual thresholds (<10 g/dL [<100 g/L], <9 [<90 <8 [<80 <7 [<70 g/L]) in MI anemia. Prespecified secondary analysis MINT (Myocardial Ischemia Transfusion) trial using target emulation methods. (ClinicalTrials.gov: NCT02981407). 144 clinical sites 6 countries. 3492 participants a level below 10 g/dL. Four...
Risk-benefit tradeoffs between restrictive versus liberal red blood cell transfusion strategies may vary across individuals. This exploratory analysis aimed to derive and evaluate individualized treatment effects of defined in patients with acute MI anemia the goal minimizing adverse cardiovascular outcomes. study analyzed 3,447 (98.4%) randomized MINT (Myocardial Ischemia Transfusion) trial April 2017 2023. Outcomes for this included 30-day death or recurrent MI, death, major events (MACE,...
Qualitative research has documented menstruator’s challenges, particularly in water and sanitation poor environments, but quantitative assessment is limited. We created validated a culturally-grounded measure of Menstrual Insecurity to assess women’s menstruation-related concerns negative experiences. With cross-sectional data from 878 menstruating women rural Odisha, India, we carried out Exploratory (EFA) Confirmatory (CFA) Factor Analyses reduce 40-item pool identify confirm the scale...
Abstract Background Process evaluations of public health programs are critical to understand if were delivered as intended and identify improvements for future implementations. Here we present a mixed methods process evaluation the Sundara Grama intervention , which sought improve latrine use safe child feces disposal among latrine-owning households in rural Odisha, India. Methods The was 36 villages Puri district by grassroots non-governmental organization (NGO) included eight activities:...
Objective To characterise individual and area-level risks associated with invasive or skin soft tissue (SSTIs) Staphylococcus aureus infections comparing methicillin-resistant S. (MRSA) methicillin-sensitive (MSSA); highlight differences between children adults. Setting A population-based study from 21 reporting laboratories located in Georgia Health District 3 (HD3), an eight-county catchment area around metro Atlanta. Participants case is a resident of HD3 whom had been isolated 2017....
Abstract Background The hemoglobin (Hgb) threshold at which red blood cell transfusion affords greatest benefit, without increasing transfusion-associated risks, is uncertain for patients with acute myocardial infarction (MI). Myocardial Ischemia and Transfusion (MINT) trial recently showed a restrictive strategy (Hgb &lt;7-8g/dL) resulted in 15% increased risk of 30-day all-cause death or recurrent MI (death/MI) compared liberal &lt;10g/dL) 3,504 adults anemia. However, the effect...
Importance In patients with acute myocardial infarction (MI), limited physiologic adaptation to anemia might lead greater benefit from a liberal red blood cell (RBC) transfusion strategy. Data on such possible are lacking. Objectives To compare chronic and post-MI outcomes estimate the differential effect of restrictive RBC strategy compared according acuity. Design, Setting, Participants A prespecified subgroup analysis Myocardial Ischemia Transfusion (MINT) multicenter randomized clinical...
Abstract BackgroundProcess evaluations of public health programs are critical to understand if were delivered as intended and identify improvements for future implementations. The aim this paper is describe a mixed methods process evaluation the Sundara Grama intervention, which sought improve latrine use safe child feces disposal among latrine-owning households in rural Odisha, India.MethodsThe intervention was 36 villages Puri district by grassroots NGO included eight activities: palla...