A5101451912- Cancer Research and Treatments
- Antibiotic Resistance in Bacteria
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Nitric Oxide and Endothelin Effects
- Listeria monocytogenes in Food Safety
- Bacterial Identification and Susceptibility Testing
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Neuroblastoma Research and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- 3D Printing in Biomedical Research
- Photodynamic Therapy Research Studies
- Antibiotic Use and Resistance
- Protease and Inhibitor Mechanisms
- Nanoplatforms for cancer theranostics
- Analytical Methods in Pharmaceuticals
- Virus-based gene therapy research
- Genetic and Kidney Cyst Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
Peking University Shenzhen Hospital
2024
Sichuan Provincial Library
2022-2023
Sichuan University
2022-2023
Xinxiang University
2018
National Institute of Environmental Health Sciences
2018
Sunnybrook Research Institute
2014-2016
Sunnybrook Health Science Centre
2011-2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Abstract Purpose: Increased tumor hypoxia and hence elevated hypoxia-inducible factor-1α (HIF1α) is thought to limit the efficacy of vascular endothelial growth factor (VEGF) pathway–targeting drugs by upregulating adaptive resistance genes. One strategy counteract this combine antiangiogenic with agents able suppress HIF1α. such possibility investigational drug CRLX101, a nanoparticle–drug conjugate (NDC) containing payload camptothecin, known topoisomerase-I poison. Experimental Design:...
Efflux is a primary fluoroquinolone resistance mechanism in Listeria monocytogenes. In the present study, ciprofloxacin resistant strains were selected by exposure of sensitive strain to progressively increasing concentrations and then roles efflux pumps Lde MdrL development also investigated L. Ciprofloxacin monocytogenes exhibited reduced susceptibility this antibiotic after induction. Cross-resistance ethidium bromide (EtBr) was observed ciprofloxacin-induced strains. However,...
Several approaches are being evaluated to improve the historically limited value of studying transplanted primary tumors derived by injection cells from established cell lines for predicting subsequent cancer therapy outcomes in patients and clinical trials. These include use genetically engineered mouse models (GEMMs) spontaneous tumors, or patient tumor tissue xenografts (PDXs). Almost all such studies utilizing involve treatment tumors. An alternative approach we have developed involves...
Regulatory factor X4 (RFX4) isoform 1 is a recently discovered of the winged helix transcription RFX4, which can bind to X-box consensus sequences that are enriched in promoters cilia-related genes. Early insertional mutagenesis studies mice first identified this isoform, and demonstrated it was crucial for mouse brain development. RFX4 only significantly expressed fetal adult brain. In study, we evaluated conditional knock-out (KO) one or two floxed alleles Rfx4 were deleted early...
Background: Bacterial persisters are thought to be responsible for the recalcitrance and relapse of persistent infections, they also lead antibiotic treatment failure in clinics. In recent years, researches on bacterial have attracted worldwide attention number related publications is increasing. The purpose this study was better understand research trends by identifying bibliometrics analyzing top 100 cited field. Methods: Web Science Core Collection utilized retrieve highly persisters,...
In the past two decades, surge of research on bacterial persisters has been inspired as increasingly concerning about frequent failure antibiotics treatment. This study was aimed at presenting a bibliometric and visualized analysis relative publications persisters, which offered insights into development trends this field.The Web Science Core Collection Ovid MEDLINE databases were utilized to retrieve relevant from 2001 2021. After manual selection, data including titles, authors, journals,...
Background: As an acute phase protein, α1-antitrypsin (AAT) has been extensively studied in coronary syndrome, but it is unclear whether a relationship exists between AAT and stable angina pectoris (SAP). The purpose of the present study was to investigate association plasma levels SAP. Methods: Overall, 103 SAP patients diagnosed by angiography clinical manifestations 118 control subjects matched for age gender were enrolled this case-control study. Plasma AAT, high-sensitivity C-reactive...
Cyclin D3 (CCND3), a member of the cyclin D family, is known to promote cell cycle transition. In this study, we found that CCND3 was downregulated in cisplatin-resistant (
Abstract Despite the approval of seven different VEGF-pathway targeting agents, such as bevacizumab, for ten cancer types, VEGF inhibition has shown only modest survival benefits - especially in breast cancer. One hypothesis this is adaptive resistance that emerges, increased tumor hypoxia and elevated hypoxia-inducible factor 1α (HIF-1α), which up-regulates genes causing angiogenesis, metastasis. Here we evaluated bevacizumab paired with a potent cytotoxic investigational drug called...