A5039675137- Ocular Diseases and Behçet’s Syndrome
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Ophthalmology and Eye Disorders
- Glaucoma and retinal disorders
- Ophthalmology and Visual Impairment Studies
- Cytomegalovirus and herpesvirus research
- Vaccine Coverage and Hesitancy
- Retinal Diseases and Treatments
- Immune responses and vaccinations
- Otitis Media and Relapsing Polychondritis
- Cerebral Venous Sinus Thrombosis
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Cerebrovascular and genetic disorders
- COVID-19 and healthcare impacts
- Osteoarthritis Treatment and Mechanisms
- Retinal and Macular Surgery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infrared Thermography in Medicine
- melanin and skin pigmentation
- RNA regulation and disease
- Ophthalmology and Visual Health Research
- Inflammasome and immune disorders
Sheffield Children's NHS Foundation Trust
2015-2025
University of Sheffield
2015-2025
Sheffield Children's Hospital
2013-2025
Royal Hallamshire Hospital
2019-2024
Sheffield Teaching Hospitals NHS Foundation Trust
2018-2023
Royal Victoria Hospital
2023
University of Ulster
2023
University Hospital of Wales
2023
University College London
2023
Dewsbury and District Hospital
2013
We aimed to provide, through the Uveitis in Childhood National Cohort Study, population-based evidence on incidence, distribution and disease characteristics for childhood onset non-infectious uveitis. Eligible children young people (<18 years) were those newly diagnosed with uveitis between 1 March 2020 28 February 2023. Cases identified recruited passive surveillance across a multicentre network. Descriptive analysis of demographic, socioeconomic clinical at diagnosis is reported alongside...
Background Adalimumab has demonstrated efficacy in non-infectious uveitis. With the introduction of biosimilar agents such as Amgevita, we aimed to quantify and tolerability compared Humira a multi-centre UK cohortMethods Patients identified from tertiary uveitis clinics 3 centres, after institution-mandated switching was implemented.Results Data collected for 102 patients, aged 2–75 years, with 185 active eyes. Following switch, rates flare were not significantly different (13 events...
Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology raised intraocular pressure (IOP) in uveitic glaucoma commonly due to increased resistance at the trabecular meshwork-Schlemm canal. By removing this resistance, GATT can potentially control IOP. In addition, approach avoids violating conjunctiva and reduces risk complications including infection,...
Abstract Background Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of adverse health outcomes place an undue financial burden on patient healthcare system given high cost. There great interest for patients to stop adalimumab following...
Aim: We describe the perceptions and experiences of healthcare services during pandemic those newly diagnosed with a rare, chronic eye disorder. Methods: A cross-sectional mixed-methods study nested within multi-center inception cohort study. Participants were UK families adolescents affected by childhood uveitis. Using validated tool (Health Foundation COVID-19 Survey), we captured quantitative (analyzed using descriptive statistics) qualitative content thematic analysis) data. Results:...
Background: Development of modern therapeutic approaches over the last decade has improved short-term well-being in JIA patients. This study examines disease damage and body composition (BC). Aims: Comparison patients’ clinical with matched controls assessing BC, cross-sectional inflammatory markers levels joint uveitis-associated relating to their management. Methods: 112 patients (disease duration ≥5 years) were cross-sectionally compared 127 age, sex, ethnicity deprivation score-matched...
The Sheffield Virtual Adult Strabismus service was already well established and put to real-time trial during the COVID-19 pandemic. We describe a multi-disciplinary adaptation offer safe effective delivery. evaluate efficacy of virtual strabismus pandemic meet clinical demand, streamline patient care, balance care delivery optimise medical input.Prospective data analysis from clinics dated January 2015 November 2021. All information captured at first consultation with comprehensive...
Background: A joint paediatric-adult uveitis transition clinic has recently been established in Sheffield involving staff from the Children's NHS Foundation Trust and Teaching Hospitals Trust.Children adults with are managed using similar treatment strategies encompassing a combination of MTX, MMF biologic treatments.We conducted service evaluation to describe response individuals receiving therapy: MTX MMF.Here we report data paediatric service.Aims: To document pathway for children young...