A5074116517- Cardiovascular Health and Disease Prevention
- Blood properties and coagulation
- Thermoregulation and physiological responses
- Blood Pressure and Hypertension Studies
- Erythrocyte Function and Pathophysiology
- Heart Rate Variability and Autonomic Control
- Spaceflight effects on biology
- Non-Invasive Vital Sign Monitoring
- Peripheral Artery Disease Management
- Electromagnetic Fields and Biological Effects
- Optical Imaging and Spectroscopy Techniques
- Climate Change and Health Impacts
- Diabetic Foot Ulcer Assessment and Management
- Neurological Disorders and Treatments
- Curcumin's Biomedical Applications
- Human Health and Disease
- Photoacoustic and Ultrasonic Imaging
- Advancements in Transdermal Drug Delivery
- Healthcare Systems and Public Health
- Acute Ischemic Stroke Management
- Diagnosis and Treatment of Venous Diseases
- Optical Coherence Tomography Applications
- Digital Imaging for Blood Diseases
- Solar and Space Plasma Dynamics
- Advanced Scientific Research Methods
Lomonosov Moscow State University
2018-2024
Moscow State University
2020-2021
Space Research Institute
2019
Russian Railways
1996-2018
Moscow Clinical Scientific Center
2017
Russian Academy of Sciences
2010-2014
Abstract Optical clearing agents (OCAs) are substances that temporarily modify tissue's optical properties, enabling better imaging and light penetration. This study aimed to assess the impact of OCAs on nail bed blood using in vivo vitro methods. In part, were applied bed, coherence tomography digital capillaroscopy used evaluate their effects capillary flow, respectively. collected samples incubated with OCA aggregation properties estimated diffuse scattering techniques. The results...
The study is aimed to determine the digital capillaroscopy possibilities in early diagnostics of an arterial hypertension. A total 123 adult persons were examined study. first group consisted 40 patients with prehypertension (BP 130–139/85–89 mm Hg). second included 36 1-2 stage hypertension (mean systolic BP 152.7±12 Patients both groups did not receive regular drug therapy. volunteers (n=47) healthy adults without signs cardiovascular pathology. capillary circulation was on nailbed using...
Aim. To assess the potential of integral assessment cardiovascular system status in patients with arterial hypertension (AH), based on evaluation parameters microcirculation (non-invasive digital capillaroscopy) and macrocirculation (pulse wave velocity (PWV) endothelial function). Material methods. The study included 188 people aged 40 years older: 32 systolic blood pressure (BP) levels 120–139 mm Hg (“PreAH” group), 36 Stage 1–2 AH (“AH” 85 who achieved target BP due to antihypertensive...
Aim. To reveal the features of microcirculatory parameters in compensated and decompensated type 2 diabetes mellitus (T2DM). Subjects methods. A total 196 patients with T2DM were examined divided into groups: 1) 52 (40.4% men) aged 52.8±8.7 years (glycated hemoglobin (HbA1с), 6.3±0.5%); 2) 68 (38.2% 52.8±8.1 (HbA1с, 9.4±1.7%). Both patient groups had concomitant hypertension (its prevalence, degree, stage comparable). control group consisted 76 volunteers (40.8% 52.2±8.7 normal carbohydrate...
Development of computer technologies and image processing techniques provides rapid improvement imaging quality in digital capillaroscopy enabling much better observation identification tiny capillaries, measurement blood flow determination capillary parameters. The main idea the study was to determine applicability optical for diagnostics early stages arterial hypertension. Diameters venous segments, perivascular zone size, velocity, degree loops narrowing density network were estimated...
The dynamics of the erythrocyte sedimentation rate (ESR) in patients with ischemic disease shows a significantly different pattern days raised geomagnetic activity as compared to quiet days. This is revealed by greater intensity ESR variations during storms when there was little or no sun (quiet sun). Such behavior red blood cells reflects patient's individual sensitivity field fluctuations. article discusses possible mechanism variations.
This study is aimed to define the extent of digital capillaroscopy possibilities for quantification and estimation microvascular abnormalities in type 2 diabetes mellitus (T2DM). A total 196 adult persons were enrolled including group compensated T2DM (n = 52), decompensated diabetics 68), healthy volunteers 76) with normal blood glucose without signs cardiovascular pathology. All participants examined optical capillaroscope ("AET", Russia). instrument equipped an image-processing program...
Aim . To study microrheological properties of RBCs and capillary blood flow parameters using optical methods in patients with arterial hypertension (AH) type 2 diabetes mellitus (DM2). Methods aggregation were evaluated vitro laser aggregometry trapping. Сapillary nail refill was vivo nailfold digital capillaroscopy. Results. The suffering from AH higher compared to healthy subjects who demonstrated a decrease the time by 29±9%. A similar trend observed DM2. comparison results obtained...
Objective: Early diagnosis of fluid retention as a complication arterial hypertension severity and prediction acute decompensation is complicated due to the absence specific symptoms objective measurable criteria. Here we present new non-invasive indicator based on digital high-resolution soft tissue optical imaging in nail-fold capillaries. Design method: One hundred twenty-nine (129) adults with were enrolled study, including 79 patients NYHA I–III functional classes heart failure, 50...
ABSTRACT In this study, the parameters of blood microcirculation and microrheology were measured using methods laser aggregometry optical tweezers in vitro, as well method digital capillaroscopy vivo. It was shown that patients suffering from type 2 diabetes mellitus, an increase number RBC aggregates passing through narrow capillaries leads to a significant decrease velocity capillary flow, which can be explained by increased viscosity whole decreased deformability RBCs. Also, for group...