A5077398724- DNA and Nucleic Acid Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Epigenetics and DNA Methylation
- Origins and Evolution of Life
- Catalytic C–H Functionalization Methods
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Molecular Junctions and Nanostructures
- RNA and protein synthesis mechanisms
- Nanowire Synthesis and Applications
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Analytical Chemistry and Sensors
Center for NanoScience
2023-2024
Ludwig-Maximilians-Universität München
2020-2024
Alkylations of simple electron‐rich heterocompounds deliver valuable target structures in bioorganic and medicinal chemistry. Herein, we present a straightforward photosensitizer free approach for the photoinduced C–C coupling unsaturated with alkyl bromides using 405 nm 365 irradiation. Comprehensive mechanistic studies indicate involvement 2,6‐lutidine formation non‐covalently bound intermediate to which function is attributed. UV/Vis spectra reveal bathochromic shifted band when...
The question of how RNA, as the principal carrier genetic information evolved is fundamentally important for our understanding origin life. RNA molecule far too complex to have formed in one evolutionary step, suggesting that ancestral proto-RNAs (first ancestor RNA) may existed, which over time into today. Here we show isoxazole nucleosides, are quickly from hydroxylamine, cyanoacetylene, urea and ribose, plausible precursors RNA. nucleoside can rearrange within an RNA-strand give cytidine,...
5-Carboxycytosine (5caC) is a rare epigenetic modification found in nucleic acids of all domains life. Despite its sparse genomic abundance, 5caC presumed to play essential regulatory roles transcription, maintenance and base-excision processes DNA. In this work, we utilize nuclear magnetic resonance (NMR) spectroscopy address the effects incorporation into canonical DNA strands at multiple pH temperature conditions. Our results demonstrate that has pH-dependent global destabilizing...
Abstract Biosensors play key roles in medical research and diagnostics, but there currently is a lack of sensing platforms that combine easy adaptation to new targets, strategies tune the response window relevant analyte concentration ranges allow for incorporation multiple elements benefit from multivalency. Utilizing DNA origami nanostructure as scaffold arranging different sensor components, we here propose an approach development modular tunable single-molecule sensors capable detecting...
Abstract Die Frage, wie sich die RNA als ein Träger der genetischen Information entwickelt hat, ist von grundlegender Bedeutung für unser Verständnis des Ursprungs Lebens. Das RNA‐Molekül viel zu komplex, das es in einem einzigen Evolutionsschritt hat entstehen können, was darauf hindeutet, dass Proto‐RNAs (erste Vorläufer RNA) gegeben haben könnte, im Laufe Zeit heutigen haben. Hier zeigen wir, Isoxazol‐Nukleoside, aus Hydroxylamin, Cyanoacetylen, Harnstoff und Ribose gebildet werden,...
Abstract 5-carboxycytosine (5caC) is a rare epigenetic modification found in nucleic acids of all domains life. Despite its sparse genomic abundance, 5caC presumed to play essential regulatory roles transcription, maintenance and baseexcision processes DNA. In this work, we utilize nuclear magnetic resonance (NMR) spectroscopy address the effects incorporation into canonical DNA strands at multiple pH temperature conditions. Our results demonstrate that has pH-dependent global destabilizing...