A5084335252- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Inorganic and Organometallic Chemistry
- Polymer Surface Interaction Studies
- Computational Drug Discovery Methods
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Telomeres, Telomerase, and Senescence
- Protein Interaction Studies and Fluorescence Analysis
- Bone Tissue Engineering Materials
- Additive Manufacturing and 3D Printing Technologies
- Synthesis and biological activity
- Bee Products Chemical Analysis
- Analytical Chemistry and Chromatography
- Nanoparticles: synthesis and applications
- Analytical Methods in Pharmaceuticals
- Marine Bivalve and Aquaculture Studies
- 3D Printing in Biomedical Research
- Metabolomics and Mass Spectrometry Studies
- Antibiotic Use and Resistance
- COVID-19 Clinical Research Studies
- Marine Invertebrate Physiology and Ecology
- Magnesium Alloys: Properties and Applications
- Heme Oxygenase-1 and Carbon Monoxide
Carol Davila University of Medicine and Pharmacy
2017-2024
Sivas Cumhuriyet Üniversitesi
2021
Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering
2021
Human immunodeficiency virus (HIV) is a significant global health issue that affects substantial number of individuals across the globe, with total 39 million living HIV/AIDS. ART has resulted in reduction HIV-related mortality. Nevertheless, medication resistance obstacle management The unique genetic composition HIV enables it to undergo rapid mutations and adapt, leading emergence drug-resistant forms. development drug can be attributed various circumstances, including noncompliance...
The pandemic caused by the SARS-CoV-2 virus has produced significant changes in socio-cultural life, diet, and interpersonal relationships across world’s population. present study aims to identify lifestyle diet among Romanian population one year after onset of COVID-19 pandemic. An online questionnaire with 58 items (addressing following aspects: socio-demographic anthropometric data, current eating habits, changes) was distributed using institutional mailing lists social media. A total...
Mussels have a particular nutritional value, representing highly valued food source and thus sought after worldwide. Their meat is real culinary delicacy, rich in proteins, lipids, carbohydrates, trace elements, enzymes, vitamins. The seasonal variation of mussels' biochemical composition has been studied to determine the best harvesting period capitalize on various biologically active fractions. In this work determinations performed fresh flesh samples Mytilus galloprovincialis specimens...
Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N′-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized characterized by different physico-chemical techniques including elemental thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well IR (infrared), 1H-NMR 13C-NMR (hydrogen carbon nuclear resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), mass...
(1) Background: The mussel (Mytilus edulis, Mytilus galloprovincialis) is the most widespread lamellibranch mollusk, being fished on all coasts of European seas. Mussels are also widely grown in Japan, China, and Spain, especially for food purposes. This paper shows an original technique shell processing preparation calcium salts, such as levulinate. process involves synthesis levulinate by treatment galloprovincialis shells with levulinic acid. advantage utilization results more...
5‐methoxy‐2‐(((2chloro‐5‐(trifluoromethyl)phenyl)imino)methyl)phenol) (HL) and its cobalt (II), copper manganese nickel palladium platinum (II) complexes, [Co(L) 2 ]·4H O ( 1 ), [Cu(L) ] [Mn(L) (H O) ]·H 3 [Ni(L) 4 [Pd(L) 5 [Pt(L) 6 were synthesized characterized. The compounds investigated by different physico‐chemical techniques including IR, H‐NMR, 13 C‐NMR, UV‐Vis, mass spectroscopies, elemental thermal analysis, magnetic susceptibility measurements, molar electric conductivity....
The pharmaceutical industry faces significant challenges when promising drug candi-dates fail during development due to suboptimal ADME (absorption, distribution, metab-olism, excretion) properties or toxicity concerns. Natural compounds are subject the same pharmacokinetic considerations. In silico approaches offer a compelling advantage: they eliminate need for physical samples and laboratory facilities, while providing rapid cost-effective alternatives expensive time-consuming...
Background/Objectives: Approximately 90% of newly developed active pharmaceutical ingre-dients (APIs) exhibit low solubility in aqueous environments. The formation cyclodextrin (CD)-guest inclusion complexes (ICs) is one method increasing the poorly soluble drugs. In contrast to its crystalline state, a compound more amorphous solid state. Methods: purpose this work was investigate how solid-state characteristics ti-cagrelor (TICA) are affected by complexation with specific cyclodextrins....
Honey and other bee products have been used for food therapeutic purposes since ancient times. There are many varieties of honey with time-proven properties, in both traditional modern medicine, along various beekeeping products. In this study, conducted based on the dissemination a questionnaire 43 questions, an evaluation consumption different types was carried out. Hence, frequency evaluated, as well pharmaceutical forms utilized purposes, population’s trust their potential, quality among...
A series of Cu(II), Co(II), Pd(II), Pt(II), Zn(II), Cd(II) and Fe(III) complexes were designed synthesized using Schiff base 1‐phenyl‐2,3‐dimethyl‐4‐( N ‐3‐formyl‐6‐methylchromone)‐3‐pyrazolin‐5‐one (HL). The new metal investigated various physicochemical techniques including elemental thermal analyses, molar electric conductivity magnetic susceptibility measurements, as well spectroscopic methods. Also, the crystal structures ligand HL Pd(II) complex determined single‐crystal X‐ray...
Extensive research has been conducted on ZrO2 nanostructures due to their favorable biocompatibility, low toxicity, and promising prospects in various biomedical applications. They can be used as drug carriers, facilitating the administration of therapeutic substances into body while enhancing effectiveness safety. This is achieved by regulating timing, location, rate at which drugs are released within body. Several factors influence loading onto nanostructures, such physicochemical...
Copper, a cofactor for many enzymes, is bioelement that involved in main biochemical processes; although high levels of copper promote the proliferation cancer cells. Further development radiopharmaceuticals based on radioisotopes depend understanding and taking advantage its pathways oncogenesis. As with other radiometals used molecular imaging and/or targeted therapy, biological vectors are employed to transport target, aiming specific uptake at tumor sites precise delivery ionizing...
Osteoprotegerin (OPG), a member of the tumour necrosis factor receptor (TNFR) superfamily proteins known to be involved in large number biological systems, plays pivotal role bone remodelling. In addition roles OPG metabolism, it has been reported associated with high cardiovascular risk patients metabolic syndrome. most cases, exact functions remain established; however, widespread expression suggests that this molecule may have multiple activities, mainly cardiometabolic environment. The...
A bidentate NO donor Schiff base, 2‐(((2‐chloro‐5‐ (trifluoromethyl)phenyl)imino)methyl) phenol ( HL 1 ) and its complexes [Co(L 2 (H O) ] ), [Cu(L [Mn(L 3 [Ni(L 4 [Pd (L (OAc) ·1.16H O] 5 [Pt(L 6 were synthesized characterized by different physico‐chemical techniques including elemental thermal analysis, magnetic susceptibility measurements, molar electric conductivity, IR, H‐NMR, 13 C‐NMR, UV–Vis, mass spectroscopies X‐ray powder diffraction (XRD). The molecular structures of ligand two...
ABSTRACT The antimicrobial, antitumor and antioxidant potential of Co(II), Cu(II), Mn(II), Ni(II), Pd(II), Pt(II) complexes with 2‐(((2‐chloro‐5‐(trifluoromethyl)phenyl)imino)methyl)phenol HL ligand was investigated. A molecular docking study carried out to estimate the predicted binding affinity compounds protein targets involved in proliferative bacterial activities. Fluorescence quenching studies synchronous spectra were used examine metal interactions CT‐DNA BSA protein. DNA have...
3D printing offers the key for manufacturing new pharmaceutical forms and devices with complex structures geometry that meet individual needs of patients, improving compliance, accessibility affordability medicines.Also, due to technologies, on demand fabrication products in critical situations may be an easy task future.In this review we focused main printers software platforms widely used at present.Also, discuss most important achievements have been obtained lately using field.
By adjusting the synthesis process, silver nanoparticles (AgNp) of various shapes, sizes, and structures can be obtained, all which have a substantial impact on biological effect, notably, regulation antibacterial activity in present circumstances growing bacterial resistance. Due to their relatively small size, may disseminated evenly throughout body experimental animal, even at low doses, exert more potent activities. Our research was centered synthesis, production, evaluation...
This paper compares two types of polylactic acid (PLA) coating on AZ31 alloy obtained by dip and electrospinning. Both were loaded with gentamicin sulphate (GS) the drug-loading efficiency release assessed. A higher encapsulation GS was seen for (73% 49.53%, respectively) compared to nanofiber (65% 12.37%, respectively). Furthermore, antibacterial effect samples without assessed using Gram-negative (Escherichia coli) Gram-positive (Staphylococcus aureus) bacteria, showing that drug...
The traditional knowledge about the therapeutic and nutritional value of fish has been unanimously recognized among population since ancient times. So, thanks to virtues these marine animals, it was possible develop therapies for certain pathologies as well use bioactive compounds adjunctive incorporated into treatment regimen patients. In present study, stingray liver oil from wild species collected Romanian coast Black Sea isolated analyzed. Fatty acid analysis performed by gas...
Given the important role of antioxidants in cellular degeneration process, as well increased interest recent years related to use natural therapy, present study aims investigate antioxidant activity a new pharmaceutical product containing extracted from plant raw materials. In first step, conventionally named “CILTAG”, mixture equal proportions 10% hydroalcoholic extractive solutions dried materials Medicaginis herba, Trifolii pratense flores, Ginkgo bilobae folium, Myrtilli fructus, and...