A5078095735- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Nuclear Physics and Applications
- Monoclonal and Polyclonal Antibodies Research
- Boron Compounds in Chemistry
- Neuroendocrine Tumor Research Advances
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Analytical Chemistry and Chromatography
- Chemical Synthesis and Characterization
- Metal and Thin Film Mechanics
- Radioactive element chemistry and processing
- Cell Adhesion Molecules Research
- Graphite, nuclear technology, radiation studies
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Radioactive Decay and Measurement Techniques
- Nanoparticle-Based Drug Delivery
- S100 Proteins and Annexins
- Muon and positron interactions and applications
- Metal Extraction and Bioleaching
- Cancer, Stress, Anesthesia, and Immune Response
- Trace Elements in Health
Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering
2013-2024
Carol Davila University of Medicine and Pharmacy
2023
Extreme Light Infrastructure - Nuclear Physics
2021
Institutul National de Cercetare si Dezvoltare pentru Fizica Pamantului
2019
Universitatea Națională de Știință și Tehnologie Politehnica București
2015
At the Radiopharmaceutical Research Center (CCR) of Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH), we operate a TR-19 cyclotron radio isotope production. To broaden our spectrum radioisotopes with applications nuclear medicine, add new external beam line towards state-of-the-art solid target station. Besides practical experience implementation Comecer ALCEO metal targetry system, new, more efficient way tuning onto design dedicated neutron local...
Unstable isotopes and their capacity to emit ionizing radiation have been employed in clinical practice not only for diagnostic, but also therapeutic purposes, with significant contribution several fields of medicine primarily the management oncologic patients. Their efficacy is associated ability provide targeted delivery a determined duration. These compounds can be used curative or palliative treatment, as well diagnostic-therapeutic (theranostic) approach. This review summarises most...
Copper, a cofactor for many enzymes, is bioelement that involved in main biochemical processes; although high levels of copper promote the proliferation cancer cells. Further development radiopharmaceuticals based on radioisotopes depend understanding and taking advantage its pathways oncogenesis. As with other radiometals used molecular imaging and/or targeted therapy, biological vectors are employed to transport target, aiming specific uptake at tumor sites precise delivery ionizing...
Antibody and nanobody-based copper-64 radiopharmaceuticals are increasingly being proposed as theranostic tools in multiple human diseases. While the production of using solid targets has been established for many years, its use is limited due to complexity target systems, which available only a few cyclotrons worldwide. In contrast, liquid targets, virtually all cyclotrons, constitute practical reliable alternative. this study, we discuss production, purification, radiolabeling antibodies...
Recent advances and large-scale use of hybrid imaging modalities like PET-CT have led to the necessity improving nano-drug carriers that can facilitate both functional metabolic screening in nuclear medicine applications. In this study, we focused on evaluation four potential nanoparticle structures labelled with 68Ga positron emitter. For purpose, functionalized NHS-activated PEG-gold nanoparticles 68Ga-DOTA-Neuromedin B, 68Ga-DOTA-PEG(4)-BBN(7-14), 68Ga-DOTA-NT N. vitro binding kinetics...
On the verge of a theranostic approach to personalised medicine, copper-64 is one emerging radioisotopes in nuclear medicine due its exploitable and biochemical characteristics. The increased demand for preclinical clinical studies has prompted development production routes. This research aims compare (p,n) reaction on nickel-64 solid versus liquid targets evaluate effectiveness [64Cu]CuCl2 solutions prepared by two As new treatments neurotensin receptor-overexpressing tumours have...
The neurotensin is a tridecapeptide involved in the proliferation of colon cancer, overexpression receptors occurring at an early stage development many tumours. Targeting by using same biological active molecule effective approach for both imaging quantification and treatment. present work aimed to demonstrate ability radiolabelled specifically target cancer cells, substantiate its usefulness targeted radiotherapy, depending on emission coupled radioisotope. Syntheses 68Ga–DOTA–NT...
64Cu is a cyclotron-produced radionuclide suitable for positron emission tomography (PET) and internal radiotherapy. We have been focused on radioisotope due to its favorable nuclear characteristics (β+ emission, 18% β− 39%). Moreover, the electron capture (43%) implies Auger with high linear energy transfer in targeted cells. Also, 12.7 hours half-life allows good uptake distribution of radiopharmaceuticals obtain qualitative images contrast. The production no-carrier-added via...
The use of radioisotopes in nuclear medicine applications became essential for the diagnosis and follow-up imaging many oncological, cardiovascular, neurodegenerative diseases, a safe non-invasive way. Their personalized treatment tumors is on verge to change oncological patient management. Optimization production aims maximize efficiency while minimizing side reactions costs. A practical approach balance these non-converging ways employ simulation tools process design phase experimental...
18 F-FDG is a glucose analog in which the hydroxyl group on second carbon substituted with F, being used as an indicator of uptake and cell viability.The aim this work was to synthesize validate methodology for assessment its both radiochemical chemical purities, according European Pharmacopoeia.The proposed encompasses three chromatographic methods: radio-HPLC, radio-TLC HS/GC.Radiochemical impurities may originate from radionuclide production, incomplete purification radiolysis after...
Due to combined therapeutical emissions, a high linear energy transfer Auger-electrons with the longer ranged β- particles, 64Cu-based radiopharmaceuticals raise particular theragnostic interest in cancer, by joined therapeutic and real-time PET imaging properties. The vitro study aimed investigate biological molecular background of 64CuCl2 therapy analyzing damages stress responses inflicted various human normal tumor cell lines. Colon (HT29 HCT116) prostate carcinoma (DU145) lines, as well...
The aim of this work was the development and validation a fast analytical method to determine residual solvents content in radiopharmaceuticals such as: 18F-Fluorodeoxyglucose (18F-FDG), 18F-Fluoroestradiol (18F-FES), 18F-Fluorothymidine (18F-FLT),18F-Fluoromisonidazole (18F-FMISO). Radiopharmaceuticals are radioactive preparations for medical purposes used nuclear medicine as tracers diagnostic imaging treatment certain diseases. Positron Emission Tomography (PET) is technique that consists...
Radioisotopes have a growing impact in various fields of industry and medicine. Especially modern medicine, based on the synergies nuclear physics, radiochemistry, radiobiology, demand for more readily available, higher quality, also new radioisotopes is constantly increasing. As key components radiopharmaceuticals, they are used many ways diagnostics imaging, treatments cancer or other health issues. Diagnostics precise positioning imaging photons improved due to recent advances molecular...
A dosimetric experiment was performed at the Medico-Technical Complex in Joint Institute for Nuclear Research, Dubna, to investigate effects of metallic dental implants treatment head and neck tumours with proton therapy. The goal study evaluate 2D dose distributions different clinical plans measured an anthropomorphic phantom, compare them predictions from a planning system. phantom sliced into horizontal segments. Two grade 4 Titanium were inserted between 2 slices, corresponding maxillary...
The most important radioisotope for nuclear medicine is [Formula: see text]Tc. After the supply crisis of text]Mo starting in 2008, availability text]Tc became a worldwide concern. Alternative methods producing medical imaging isotope are actively being developed around world. reaction text]Mo(p, 2n)[Formula: provides direct route that can be incorporated into routine production centers possess cyclotrons other isotopes, such as those used Positron Emission Tomography. This paper describes...