A5045693740- Bone Metabolism and Diseases
- Oral microbiology and periodontitis research
- Cancer-related molecular mechanisms research
- Cardiac Arrhythmias and Treatments
- Light effects on plants
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Plant Gene Expression Analysis
- Protease and Inhibitor Mechanisms
- Oral Health Pathology and Treatment
- Lipid metabolism and disorders
- Extracellular vesicles in disease
- Endodontics and Root Canal Treatments
- Bone and Dental Protein Studies
- NF-κB Signaling Pathways
- Regional Development and Environment
- Ultrasound and Hyperthermia Applications
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Shoulder Injury and Treatment
- Adipose Tissue and Metabolism
- Antimicrobial Peptides and Activities
- Spectroscopy and Chemometric Analyses
- Cardiovascular Effects of Exercise
- Genomics, phytochemicals, and oxidative stress
Beijing Anzhen Hospital
2015-2025
Capital Medical University
2020-2025
Changhai Hospital
2024
Second Military Medical University
2024
Jiangxi Agricultural University
2023
Wuhan University
2017-2023
Liaocheng University
2023
Union Hospital
2022-2023
Huazhong University of Science and Technology
2022-2023
Jiang Xi Institute for Drug Control
2015
Periodontitis is a prevalent and chronic inflammatory disease that interrelated with systemic health. can be promoted by tumor necrosis factor α (TNF-α). Cementum, vital part of the periodontium, bone-like mineralized tissue produced cementoblasts. Our laboratory previously revealed TNF-α inhibits cementoblast differentiation mineralization. However, how modulates mineralization remains largely unknown. MicroRNA-155 (miR-155) induced regulates TNF-α-inhibited osteogenic differentiation. In...
Porphyromonas (P.) gingivalis associates tightly with periodontal diseases and it is also a dominant pathogen of periapical periodontitis.However, the influence P. on cementoblasts, root surface cells pivotal in apical areas, possible involvement other molecules remain largely elusive.CXXC5 nuclear protein that regulates gene expression as well cell growth, differentiation, apoptosis.In this study, repressed mineralization capacity cementoblasts by inducing inflammatory reactions inhibiting...
Abstract Tooth cementum is a bone‐like mineralized tissue and serves as microbial barrier against invasion destruction. Cementum also responsible for tooth stability defending pulp from outside stimuli, which formed by cementoblasts. Although it crucial periodontal periapical diseases, the mechanisms underlying pathophysiological changes of cementoblasts their inflammatory responses remain unclear. MiR‐181b found to modulate vascular inflammation endotoxin tolerance. In this study,...
The development of periodontal tissue is a complex process, including cementoblast proliferation and differentiation. Emerging reports suggest that microRNAs (miRNAs) play crucial roles in gene regulatory networks governing numerous biological processes. However, how miRNAs modulate differentiation remains largely unknown. In previous study, we performed miRNA microarray profiling to fully reveal the expression patterns involved We focused on miR-361-3p, which decreased during Overexpression...
Periodontitis is an inflammatory disease of the periodontium. However, hub genes in periodontitis and their correlation with immune cells are not clear. This study aimed to identify infiltration properties explore between cells.Differentially expressed (DEGs) analysis weighted gene co-expression network (WGCNA) were performed both on GSE10334 GSE173078 datasets. Hub identified via WGCNA DEGs. The proportions infiltrating calculated by CIBERSORT algorithm, single-cell RNA-sequencing dataset...
In this study scales and items for the Oral Cancer Quality-of-life Questionnaire (QOL-OC) were designed instrument was evaluated. The QOL-OC developed modified using international definition of quality life (QOL) promulgated by European Organization Research Treatment (EORTC) analysis precedent measuring instruments. contents each item determined in context specific characteristics oral cancer. Two hundred thirteen cancer patients asked to complete both EORTC core questionnaire (EORTC...
To address the issue of pipeline blockage caused by formation waxy deposits inside pipelines, hindering flow petroleum in Shengli oilfield, eight new-style polyacrylic acid pour point depressants (PPD) for crude oil were prepared maleic anhydride and ene monomers with different polar aromatic pendant chains. The synthesized Pour Point Depressants characterized Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), polarizing...
Periodontitis is a chronic inflammatory disease that compromises the integrity of supporting tissues teeth and leads to loss alveolar bone. The Mir338 cluster has been proven be potential target for treatment osteoporosis also enriched in gingival with periodontitis; however, its role periodontitis remains unknown. Here, we aimed use as model expand our understanding osteoimmunology propose new protect against bone during progression. Significant enrichment was validated from patients...
Abstract Background Human periodontitis is a highly prevalent inflammatory disease that leads to connective tissue degradation, alveolar bone resorption, and tooth loss. Angiopoietin‐like 2 (ANGPTL2) regulates chronic inflammation in various diseases functionally involved maintaining homeostasis promoting regeneration, but there limited information about its function periodontitis. Here we investigated the expression explicit role of ANGPTL2 Methods Immunohistochemistry quantitative...
Identification of flowering-time related genes in Arabidopsis thaliana has very important and meaningful to understand the regulation mechanism flowering-time. One late flowering mutant plant which displays a delayed transition was obtained from T-DNA insertion library. SDR6, encodes short-chain dehydrogenase/reductase containing NAD(P)-binding domain Arabidopsis, been identified as novel gene by further analyzing SDR6 complementing plants. The sdr6 plants displayed later than wild-type both...
Abstract Background and Objective Emerging evidence has uncovered that long noncoding RNAs (lncRNAs) messenger (mRNAs) exert biofunctions on cellular mineralization bone formation. In this study, we aimed to identify lncRNA–mRNA expression profiles patterns, explore their underlying during cementoblast mineralization. Materials Methods Cementoblasts were cultured in mineralized medium for 0, 7, 14 days. We used quantitative real‐time polymerase chain reaction (qRT‐PCR) western blot (WB)...
Pulmonary artery remodeling is a characteristic feature of broiler ascites syndrome(BAS). endothelial cells (PAECs) regulated by HIF-1α play critical role in pulmonary remodeling, but the underlying mechanisms BAS remain unclear. In this experiment, primary PAECs were cultured vitro and identified coagulation factor VIII. After hypoxia RNA interference, The mRNA protein expression levels VEGF determined qPCR Western blotting. transcriptome profiles obtained sequencing. Our results showed...