A5035855334- Ethnobotanical and Medicinal Plants Studies
- Malaria Research and Control
- Moringa oleifera research and applications
- Research on Leishmaniasis Studies
- Cancer therapeutics and mechanisms
- Hibiscus Plant Research Studies
- Tuberculosis Research and Epidemiology
- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Mosquito-borne diseases and control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacological Effects of Medicinal Plants
- Phytochemistry and Bioactivity Studies
- Phytochemistry and biological activities of Ficus species
- Bioactive Compounds and Antitumor Agents
- Diverse Scientific Research Studies
- Traditional and Medicinal Uses of Annonaceae
- Natural Antidiabetic Agents Studies
- Bioactive natural compounds
- Phytochemistry and Bioactive Compounds
- Biochemical Acid Research Studies
- HIV/AIDS Research and Interventions
- Insect Pest Control Strategies
- Garlic and Onion Studies
Kenya Medical Research Institute
2009-2025
University of Cape Town
2014-2021
South African Medical Research Council
2014-2021
This study evaluated Ocimum gratissimum and Rhoicissus tridentata for their In vitro antimalarial activity safety. The plant samples collected from Keiyo South in Kenya were processed compounds extracted using inorganic organic solvents. Phytochemical screening, antiplasmodial bioassays, cytotoxicity tests, statistical analyses conducted to validate compare the efficacies of two used traditionally treatment malaria Kenya. O. extracts showed strong inhibition low toxicity, with methanol as...
Malaria is a global health crisis. Drug resistance underscores the urgency of developing new antimalarial treatments. Currently, medicinal plants are being explored for potential solutions, offering hope in fight against deadly disease. This study examines Ocimum gratissimum and Rhoicissus tridentate through comprehensive analyses their phytochemical, nutritional, mineral profiles, aiming to assess malaria treatment. The O. R. aqueous methanol solvents extracts yields were quantified...
Background: Whereas the efficacy of Entada abyssinica (fabaceae) extracts against various ailments has been scientifically validated, its safety not established. This study was undertaken to evaluate toxicity effects methanolic stem bark extract E. on biochemical, haematological and histological parameters Wistar albino rats following repeated oral administration. Methods: both sexes were randomized into groups orally administered daily with determined doses (150, 300 600 mg/kg) using 1%...
Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third antimicrobial resistance (AMR) deaths annually. We aimed identify synergistic anti-TB drug combinations with the capacity restore therapeutic efficacy against drug-resistant mutants causative
Welw ex. Oliver (Fabaceae) is one of the plants used by herbalists in East Africa community to prepare herbal remedies for management symptoms TB. Despite its widespread use, antimycobacterial activity this plant was uninvestigated and there contradicting information regarding cytotoxicity.
Tuberculosis (TB), an airborne disease, is among the ten leading deadly diseases worldwide. Despite efforts of WHO and its partners to eradicate it, it still a public health issue especially with rise multi-drug resistant tuberculosis (MDR-TB) extensively drug- (XDR-TB). Commiphora species (Burseraceae family) are known in Kenyan traditional medicine treat respiratory including TB. In search new anti-TB alternative drugs, plant materials from mildbraedii Engl. (root bark stem bark), edulis...
Abstract Malaria has continued to be a major global public health problem and concern in most of African countries. An estimated 350–500 million cases malaria each year result about one million deaths, mainly children under five. The rate infection is increasing rapidly partly due drug resistance by the Plasmodium falciparum. cost current drugs prohibitive poor. There therefore urgent need identify new antimalarial agents that are effective, safe affordable. In our continuous search for...
Chlorpromazine (CPZ) metabolites naturally generated <italic>in vivo</italic> were synthesized <italic>via</italic> a non-classical Polonovski reaction. CPZ and the exhibited clear synergy when tested in combination with number of antituberculosis drugs.
1. Esterases may play a major role in the clearance of drugs with functional groups amenable to hydrolysis, particularly case ester prodrugs. To understand processes involved elimination such drugs, it is necessary determine esterases involved. However, tools currently available for this enzyme phenotyping are relatively scarce. 2. The work was aimed at summarizing selectivity esterase inhibitors carboxylesterases 1 and 2 (CES1 CES2) human liver clarify their suitability phenotyping....
Abstract Background Vector control is an essential component in prevention and of malaria endemic areas. Insecticide treated nets one the standard tools recommended for vector control. The objective study was to determine physical integrity insecticidal potency long-lasting (LLINs) used Kirinyaga County, Kenya. Method targeted households area which had received LLINs during mass net distribution 2016 from Ministry Health. A total 420 were sampled using systematic sampling method, where...