A5021326572- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Signaling Pathways in Disease
- Toxin Mechanisms and Immunotoxins
- Head and Neck Cancer Studies
- RNA and protein synthesis mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Glioma Diagnosis and Treatment
- Phytoplasmas and Hemiptera pathogens
- Myasthenia Gravis and Thymoma
- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Phytochemistry and Bioactive Compounds
- Foreign Language Teaching Methods
- Genomics and Phylogenetic Studies
- DNA and Nucleic Acid Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Intraperitoneal and Appendiceal Malignancies
- Cell Image Analysis Techniques
- Atherosclerosis and Cardiovascular Diseases
- Receptor Mechanisms and Signaling
University of Gothenburg
2021-2023
Albany Medical Center Hospital
2023
Umeå University
2013-2020
Islamic Azad University, Isfahan
2013
Islamic Azad University of Najafabad
2013
Recently, a genome-wide association study showed that single nucleotide polymorphism (SNP) -rs11706832-in intron 2 of the human LRIG1 (Leucine-rich repeats and immunoglobulin-like domains 1) gene is associated with susceptibility to glioma. However, mechanism by which rs11706832 affects glioma risk remains unknown; additionally, it unknown whether expression levels are relevant determinant gliomagenesis. Here, we investigated role Lrig1 in platelet-derived growth factor (PDGF)-induced...
BackgroundThe leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, LRIG3. LRIG1 negatively regulates growth factor signaling, but little is known regarding the functions of LRIG2 In oligodendroglial brain tumors, high expression correlates with poor patient survival. Lrig1 Lrig3 knockout mice are viable, there have been no reports on Lrig2-deficient to date. Methodology/Principal...
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor negative regulator of several receptor tyrosine kinases. The molecular mechanisms by which LRIG1 mediates its effects regulates kinases remain incompletely understood. Here, we performed yeast two-hybrid screen to identify novel LRIG1-interacting proteins mined data from the BioPlex (biophysical interactions ORFeome-based complexes) protein interaction repository. putative interactors identified in were...
Genetic factors confer risk for cardiovascular disease. Recently, large genome-wide population studies have shown associations between genomic loci close to LRIG3 and heart failure plasma high-density lipoprotein (HDL) cholesterol level. Here, we ablated Lrig3 in mice investigated the importance of function lipid levels. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) was used analyze expression hearts wild-type Lrig3-deficient mice. In addition, molecular,...
Abstract In Escherichia coli, replication of both strands genomic DNA is carried out by a single replicase—DNA polymerase III holoenzyme (pol HE). However, in certain genetic backgrounds, the low-fidelity TLS polymerase, V V) gains access to undamaged where it promotes elevated levels spontaneous mutagenesis preferentially on lagging strand. We employed active site mutants pol IIIα_S759N) and V_Y11A) analyze ribonucleotide incorporation removal from E. coli chromosome genome-wide scale under...
Abstract Background Leucine-rich repeats and immunoglobulin-like domains 1 ( LRIG1 ) copy number alterations unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, loss was recently shown predict early late relapse stage I-II Methods We developed droplet digital PCR (ddPCR) assays for the determination of relative numbers used these analyze twelve healthy individuals, 34 tumor samples previously analyzed by fluorescence situ hybridization (FISH), 423...
Ribonucleotides are frequently incorporated into DNA and can be used as a marker of replication enzymology. To investigate on genome-wide scale, how E. coli pol V accesses undamaged chromosomal during the SOS response, we mapped location ribonucleotides by steric gate variants across entire genome. do so, strains that deficient in ribonucleotide excision repair (ΔrnhB), IV polymerase, constitutively express all SOS-regulated genes [lexA(Def)] "activated" RecA* (recA730). The also harbor two...
Hypoxia, i.e., inadequate oxygen supply, is a common condition in glioblastomas and other tumors that appears to promote malignant progression. Many of the cellular effects hypoxia are mediated by transcription factors belonging hypoxia-inducible factor (HIF) family. However, downstream targets HIFs their role progression not fully understood. Leucine-rich repeats immunoglobulin-like domains 1 (LRIG1) proposed tumor suppressor inhibits glioma growth downregulated compared with lower grade...
Abstract Background Leucine-rich repeats and immunoglobulin-like domains 1 ( LRIG1 ) copy number alterations unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, loss was recently shown predict early late relapse stage I-II Methods We developed droplet digital PCR (ddPCR) assays for the determination of relative numbers used these analyze twelve healthy individuals, 34 tumor samples previously analyzed by fluorescence situ hybridization (FISH), 423...
Abstract Introduction/Objective We present the second case of colonic mucocele with dysplasia. To date, only five cases have been reported, all in setting a pouch or bypass, one them showing The exceptional rarity lesion provides unique insight into etiology mucocele. Methods/Case Report A 44-year-old male complex surgical history including pull-through procedure for imperforate anus at birth, and later proctectomy end colostomy due to poor anorectal function, presented worsening low back...
Abstract Background Leucine-rich repeats and immunoglobulin-like domains 1 ( LRIG1 ) copy number alterations unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, loss was recently shown predict early late relapse stage I-II cancer.Methods We developed droplet digital PCR (ddPCR) assays for the determination of relative numbers used these analyze twelve healthy individuals, 34 tumor samples previously analyzed by fluorescence situ hybridization...
Abstract Background: Leucine-rich repeats and immunoglobulin-like domains 1 ( LRIG1 ) copy number alterations unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, loss was recently shown predict early late relapse stage I-II Methods: We developed droplet digital PCR (ddPCR) assays for the determination of relative numbers used these analyze twelve healthy individuals, 34 tumor samples previously analyzed by fluorescence situ hybridization (FISH),...