A5080978823- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Bacillus and Francisella bacterial research
- Cardiovascular Function and Risk Factors
- Metabolism, Diabetes, and Cancer
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Neuroendocrine Tumor Research Advances
- Peroxisome Proliferator-Activated Receptors
- Neuroblastoma Research and Treatments
- Cardiovascular and exercise physiology
- Advanced MRI Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Renin-Angiotensin System Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Muscle Physiology and Disorders
- Neuroscience and Neuropharmacology Research
- Cancer, Lipids, and Metabolism
- Neuropeptides and Animal Physiology
- Bacterial Genetics and Biotechnology
Umeå University
2001-2023
Norwegian University of Science and Technology
2005-2014
Ericsson (Hungary)
2014
NTNU Samfunnsforskning
2010
St Olav's University Hospital
2005
Lund University
1980-2004
Helsingborgs lasarett
2004
University of Missouri–Kansas City
2002
KTH Royal Institute of Technology
2000
Swedish Defence Research Agency
1995-1997
AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is in response to an shortage imposed by physical activity and caloric restriction. We here report on the identification PAN-AMPK activator O304, which — diet-induced obese mice increased glucose uptake skeletal muscle, reduced β cell stress, promoted rest. Accordingly, O304 fasting plasma levels homeostasis model assessment insulin resistance (HOMA-IR) proof-of-concept phase IIa clinical trial type 2 diabetes...
Ketogenic low-carbohydrate high-fat (LCHF) diets are popular among young, healthy, normal-weight individuals for various reasons. We aimed to investigate the effect of a ketogenic LCHF diet on low-density lipoprotein (LDL) cholesterol (primary outcome), LDL subfractions and conventional cardiovascular risk factors in blood women. The study was randomized, controlled, feeding trial with crossover design. Twenty-four women were assigned 4 week (4% carbohydrates; 77% fat; 19% protein) followed...
The adaptation of facultative intracellular bacteria to host macrophages involves regulation the synthesis bacterial proteins. We analyzed protein Francisella tularensis LVS growing intracellularly in macrophage-like murine cell line J774 and extracellularly culture medium. After pulse-labeling with [35S] methionine separation by one- two-dimensional polyacrylamide gel electrophoresis, induction a few proteins during growth was demonstrated. One them, 23-kDa protein, prominently induced also...
Excess body fat is a major health issue and risk factor for the development of numerous chronic diseases. Low-carbohydrate diets like Atkins Diet are popular rapid weight loss, but long-term consequences remain subject debate. The Scandinavian low-carbohydrate high-fat (LCHF) diet, which has been in countries about decade, very low carbohydrate content (~5 E %) rich includes high proportion saturated fatty acids. Here we investigated metabolic physiological diet with macronutrient...
Journal Article Persistence of Cell-Mediated Immunity and Decline Humoral to the Intracellular Bacterium Francisella tularensis 25 Years after Natural Infection Get access Mats Ericsson, Ericsson Department Infectious Diseases, University Umeå, Microbiology, National Defense Research Establishment, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Gunnar Sandström, Sandström Anders Sjöstedt, Sjöstedt Arne Tärnvik Reprints or correspondence: Dr. Tärnvik,...
The response of the facultative intracellular bacterium Francisella tularensis LVS to stress was assayed by pulse-labeling with [35S]methionine followed two-dimensional gel electrophoresis and autoradiography. A temperature increase from 37 42 degrees C or exposure 5 mM hydrogen peroxide induced increased syntheses at least 15 proteins. Among these proteins were a 75-, 60-, 10-kDa protein. By N-terminal sequence analysis, three found be extensively homologous highly conserved chaperone DnaK,...
Acetylsalicylic acid (ASA) is a cornerstone in the treatment of coronary artery disease (CAD) due to its antiplatelet effect. Cessation aspirin before bypass grafting (CABG) often recommended avoid bleeding, but practice controversial because it suggested worsen underlying CAD. The aims present prospective, randomized study were assess if ASA administration until day CABG decreases oxidative load through reduction inflammation and myocardial damage, compared with patients preoperative...
Objective An electron paramagnetic resonance (EPR) technique using the spin probe cyclic hydroxylamine 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) was introduced as a versatile method for high precision quantification of reactive oxygen species, including superoxide radical in frozen biological samples such cell suspensions, blood or biopsies. Materials and Methods Loss measurement accuracy due to variations sample size shape were minimized by assembling well-defined...
Cytokine expression was determined in the livers of mice inoculated subcutaneously with Francisella tularensis LVS. During first 48 h infection, there a logarithmic increase bacteria liver, doubling time 2.5 h. Within h, tumor necrosis factor alpha (TNF-alpha), interleukin 10 (IL-10), IL-12, and gamma interferon (IFN-gamma) mRNAs were expressed, production TNF-alpha IFN-gamma demonstrated. There no within 96 mRNA from IL-2, IL-3, or IL-4. After subcutaneous inoculation heat-killed LVS, any...
Abstract Age is associated with progressively impaired, metabolic, cardiac and vascular function, as well reduced work/exercise capacity, mobility, hence quality of life. Exercise exhibit positive effects on age-related dysfunctions diseases. However, for a variety reasons many aged individuals are unable to engage in regular physical activity, making the development pharmacological treatments that mimics beneficial exercise highly desirable. Here we show pan-AMPK activator O304, which...
The groE operon of Francisella tularensis LVS, encoding the heat shock proteins chaperone-10 (Cpn10) and Cpn60, was sequenced characterized, T-cell response LVS-vaccinated individuals to two third major chaperone, Ft-DnaK, assayed. cpn10 cpn60 genes were amplified by PCR with degenerate oligonucleotides derived from N-terminal sequence proteins. analysis revealed expected open reading frames, estimated Mrs 10,300 57,400. deduced amino acid sequences closely resembled Cpn10 Cpn60 other...
Decades after recovery from tularemia, circulating alphabeta T cells are known to still recognize a variety of membrane proteins Francisella tularensis. We studied the cell response 3 cytoplasmic heat shock organism: DnaK, chaperone-60 (Cpn-60) and Cpn-10. Determination subpopulations responding was special interest as it has been suggested that homologs these conserved may be recognized by human gammadelta cells. Compared with reference subjects no history tularemia or vaccination, who had...
A consecutive series of 11 patients with post-traumatic acute acalculous cholecystitis is reviewed. Three had sustained multiple trauma, whereas 6 recently undergone alimentary tract surgery and 2 orthopaedic or gynaecological surgery. All were treated by cholecystectomy. Four cases required reoperation because an abdominal abscess a subcutaneous abscess. One patient was re-explored due to haemorrhage from the gallbladder bed, another occlusion coeliac axis. The mortality rate 18 per cent....
Francisella tularensis is used as a model organism in studies of mechanisms behind the induction protective T-cell response mammalian host. Protective immunity associated with CD4 and CD8 towards mosaic proteins F. due to HLA restriction, each individual selects her own mosaic. No single protein has so far been shown be immunodominant. Only live affords effective host protection. Subcellular antigen preparations induce only marginal even when combined potent adjuvants such immunostimulating...
Non-invasive imaging methods like echocardiography and magnetic resonance (MRI) are very valuable in longitudinal follow-up studies of cardiac function small animals. To be able to compare results from using different methods, explain possible differences, it is important know the agreement between these methods. As both self-gated high-field MRI high-frequency (hf-echo) M-mode potential for evaluation left ventricular (LV) healthy mice, our aim was assess two Fifteen female C57BL/6J mice...
Estrogen deficiency promotes bone loss and skeletal muscle dysfunction. Peroxisome proliferator-activated receptors (PPARs) have 3 subtypes (α, δ, γ). PPARγ agonists induce loss, whereas PPARα increase mass. Although PPARδ are known to influence metabolism, the effects unsettled. This study investigated musculoskeletal of agonist GW501516 in ovariectomized (OVX) rats. Female Sprague Dawley rats, 12 weeks age, were allocated a sham-operated group OVX groups; high-dose (OVX-GW5), low-dose...