A5046655006- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Immune responses and vaccinations
- Infective Endocarditis Diagnosis and Management
- Diphtheria, Corynebacterium, and Tetanus
- Aquaculture Nutrition and Growth
- Respiratory Support and Mechanisms
- Plant Virus Research Studies
- HIV Research and Treatment
- Inhalation and Respiratory Drug Delivery
- Long-Term Effects of COVID-19
- Coccidia and coccidiosis research
- Neonatal Respiratory Health Research
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders
- Mosquito-borne diseases and control
- Aquatic life and conservation
- Congenital Diaphragmatic Hernia Studies
- Agricultural pest management studies
- Viral Infections and Vectors
- Water Quality Monitoring Technologies
- interferon and immune responses
- Eosinophilic Disorders and Syndromes
University of California, Davis
2021-2025
Livestock Breeding and Veterinary Department
2022
California Department of Public Health
2022
Smithsonian Institution
2022
Zoological Society of San Diego
2022
Veterinary Medical Teaching Hospital
2021
Brown University
2020
University of Pennsylvania
2019
The global impact of the COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), persists in part due to emergence new variants. Understanding variant-specific infection dynamics and pathogenesis murine models is crucial for identifying phenotypic changes guiding development countermeasures. To address limitations earlier studies that investigated only a few variants or used small sample sizes, we evaluated clinical disease, kinetics, viral titers, cellular...
Despite a substantial body of research, we lack fundamental understanding the pathophysiology COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) including pulmonary and cardiovascular outcomes, in part due to limitations murine models. Most models use transgenic mice (K18) that express human (h) angiotensin converting enzyme ( ACE2 ), knock-in (KI) mice, or mouse-adapted strains SARS-CoV-2. Further, many SARS-CoV-2 variants produce fatal neurologic disease K18...
Canine acute eosinophilic dermatitis with oedema (CAEDE) and sterile neutrophilic dermatosis have overlapping clinical histopathological features.The objective of this study was to identify features that differentiate these entities.Forty dogs.Retrospective case series. Forty cases diagnoses either CAEDE and/or were included based on review. Medical records (29 40 dogs) reviewed for findings historical data. Commercially available immunohistochemical stains granulocytes a Luna stain...
Abstract The utility of COVID-19 convalescent plasma (CCP) for treatment immunocompromised patients who are not able to mount a protective antibody response against SARS-CoV-2 and have contraindications or adverse effects from currently available antivirals remains unclear. To better understand the mechanism protection in CCP, we studied viral replication disease progression infected hamsters treated with CCP obtained recovered COVID that had also been vaccinated an mRNA vaccine, hereafter...
Definitive data demonstrating the utility of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) for treating immunocompromised patients remains elusive. To better understand mechanism action CCP, we studied viral replication and progression in severe acute respiratory syndrome 2 (SARS-CoV-2)-infected hamsters treated with CCP obtained from recovered COVID-19 that were also vaccinated an mRNA vaccine, hereafter referred to as Vaxplas. Vaxplas transiently enhanced severity lung...
The rapid emergence and global dissemination of SARS-CoV-2 that causes COVID-19 continues to cause an unprecedented health burden resulting in nearly 7 million deaths. While multiple vaccine countermeasures have been approved for emergency use, additional treatments are still needed due sluggish rollout, hesitancy, inefficient vaccine-mediated protection. Immunoadjuvant compounds delivered intranasally can guide non-specific innate immune responses during the critical early stages viral...
Abstract Nonhuman primates living in proximity to humans increase risks for sylvatic arbovirus transmission. We collected serum samples from nonhuman Hlawga National Park near Yangon, Myanmar, and detected antibodies against chikungunya (33%) Japanese encephalitis (4%) viruses. Buffer zones between primate human communities might reduce cross-species
Background: The axis formed by CXC chemokine receptor 4 (CXCR4), expressed on mesenchymal stromal cells (MSCs), and cell-derived factor-1 (SDF-1), in recipient organs, is a critical mediator of MSC migration non-pulmonary injury models. role regulation SDF-1 expression preterm lungs, potential relevance for MSC-based cell therapy bronchopulmonary dysplasia (BPD), unknown. aim this study was to determine the spatiotemporal pattern CXCR4/SDF-1 lungs extremely infants at risk BPD.Methods:...
Twenty-one white-rumped shamas (19 necropsied, 2 biopsied) ( Copsychus malabaricus) housed at the San Diego Zoo between 1992 and 2020 were diagnosed with Isospora infection based on evaluation of histologic sections. Review these cases revealed a consistent lesion characterized by nodular aggregates atypical epithelioid macrophages containing few intracytoplasmic protozoa, or without lymphocytic infiltrates. Of 19 necropsied cases, 16 (84%) had systemic lesions variably affecting liver,...
Introduction Percussive stunning is a widely used and ethically supported method of fish per welfare standards as part one- or two-step slaughter process. In this study, the use non-penetrative captive bolt (NPCB) gun was evaluated an effective one-step improving for juvenile adult farmed white sturgeon (Acipenser transmontanus) at slaughter. Methods A Jarvis HPS-1 NPCB operated pressures 120, 135, 145 PSI (827.37, 930.79, 999.74 kPa, respectively) (n = 3 operating pressure) 175, 200, 225...
ABSTRACT The rapid emergence and global dissemination of SARS-CoV-2 that causes COVID-19 continues to cause an unprecedented health burden resulting in nearly 7 million deaths. While multiple vaccine countermeasures have been approved for emergency use, additional treatments are still needed due sluggish rollout, hesitancy, inefficient vaccine-mediated protection. Immunoadjuvant compounds delivered intranasally can guide non-specific innate immune responses during the critical early stages...