A5101858387- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Blood disorders and treatments
- Effects and risks of endocrine disrupting chemicals
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Arsenic contamination and mitigation
- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Advanced Glycation End Products research
- Phytochemistry and biological activities of Ficus species
- Amyotrophic Lateral Sclerosis Research
- Wound Healing and Treatments
- PARP inhibition in cancer therapy
- Renin-Angiotensin System Studies
- Body Composition Measurement Techniques
- Enterobacteriaceae and Cronobacter Research
City of Hope
2018-2024
Beckman Research Institute
2018-2024
Tarbiat Modares University
2023
Semnan University of Medical Sciences
2019-2022
Tabriz University of Medical Sciences
2022
Toronto Western Hospital
2021
Torbat Heydarieh University of Medical Sciences
2020
Mazandaran University of Medical Sciences
2018-2019
Tehran University of Medical Sciences
2017
The University of Sydney
2012-2017
Transforming growth factor-β1 (TGF-β)-induced fibrotic and inflammatory genes in renal mesangial cells (MCs) play important roles glomerular dysfunction associated with diabetic nephropathy (DN). TGF-β regulates gene expression MCs by altering key chromatin histone modifications at target promoters. However, the role of repressive H3 lysine 27 trimethylation (H3K27me3) modification is unclear. Here we show that reduces H3K27me3 Ctgf, Serpine1, Ccl2 promoters rat (RMCs) reciprocally...
Abstract Diabetic kidney disease (DKD) is a major complication of diabetes. Expression members the microRNA (miRNA) miR-379 cluster increased in DKD. miR-379, most upstream 5′-miRNA cluster, functions endoplasmic reticulum (ER) stress by targeting EDEM3. However, vivo remain unclear. We created knockout (KO) mice using CRISPR-Cas9 nickase and dual guide RNA technique characterized their phenotype screened for targets renal mesangial cells from WT vs. miR-379KO AGO2-immunopreciptation CLASH...
Autophagy plays a key role in the pathogenesis of kidney diseases, however its diabetic nephropathy (DN), and particularly glomerular mesangial cells (MCs) is not very clear. Transforming Growth Factor- β1 (TGF-β), player DN, regulates expression various microRNAs (miRNAs), some which are known to regulate autophagy genes. Here we demonstrate that miR-192, induced by TGF-β signaling, an important regulating DN. The genes was decreased kidneys streptozotocin-injected type-1 type-2 (db/db)...
Long noncoding RNAs (lncRNAs) are increasingly implicated in the pathology of diabetic complications. Here, we examined role lncRNAs monocyte dysfunction and inflammation associated with human type 2 diabetes mellitus (T2D). RNA sequencing analysis CD14+ monocytes from patients T2D versus healthy controls revealed downregulation antiinflammatory antiproliferative genes, along several lncRNAs, including a potentially novel divergent lncRNA regulated (DRAIR) its nearby gene CPEB2. High glucose...
Background: Obesity and diabetes are associated with elevated free fatty acids like palmitic acid (PA), which promote chronic inflammation impaired resolution cardiometabolic disorders. Long noncoding RNAs (lncRNAs) implicated in inflammatory processes; however, their roles PA-regulated unclear. Methods: We performed RNA-sequencing analysis to identify coding genes novel lncRNAs CD14 + monocytes from healthy volunteers. investigated the regulation function of an uncharacterized PA-induced...
ABSTRACT Background Type 2 diabetes (T2D) is associated with accelerated vascular complications like hypertension and atherosclerosis. “Phenotypic switching” of smooth muscle cells (SMC), a major driver these complications, enhanced in diabetes. Despite adequate glycemic control, SMC dysfunction can persist due to “metabolic memory” prior hyperglycemia. However, the mechanisms hyperglycemic memory persistent are unclear. Here, leveraging single-cell (sc) multi-omics, we examined effect...
Chitosan-coated Fe3O4 nanoparticles were developed with the purpose of removing arsenic from aqueous solution. Chitosan was first carboxymethylated and then covalently bounded on surface via carbodiimide activation. The grafted chitosan contributed to enhancement adsorption capacity, because strong ability chitosan's multiple hydroxyl amino groups adsorb arsenic. prepared magnetic adsorbent characterized by Transmission electron microscopy (TEM), vibrating sample magnetometer, Fourier...
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play key roles in diabetic kidney disease (DKD). The miR-379 megacluster of miRNAs its host transcript lnc-megacluster (lncMGC) are regulated by transforming growth factor-β (TGF-β), increased the glomeruli mice, promote features early DKD. However, biochemical functions lncMGC unknown. Here, we identified lncMGC-interacting proteins
Neutrophils are important for wound repair, but their persistence can impair the healing process. express matrix metalloproteinases including MMP-9 and its regulator neutrophil gelatinase associated lipocalin (NGAL). Whether wounding affects NGAL in diabetic animals is not known. Skin tissue was examined by qRT-PCR immunohistochemistry control, insulin treated rats. The temporal expression of mRNA, activity NGAL/MMP-9 complex also investigated an implant model circulating neutrophils....
We investigated the role of microRNA (miR-379) in pathogenesis obesity, adipose tissue dysfunction, and insulin resistance (IR). used miR-379 knockout (miR-379KO) mice to test whether loss affects high-fat diet (HFD)-induced obesity IR via dysregulation key targets tissue. Increases body weight, hyperinsulinemia, wild-type (WT)-HFD were significantly attenuated miR-379KO-HFD with some sex differences. Relative control chow-fed mice, WT-HFD expression C/EBP homologous protein (
Obesity is associated with increased risk for diabetes and damage to the kidneys. Evidence suggests that miR-379 plays a role in pathogenesis of diabetic kidney disease. However, its involvement obesity-induced injury not known was therefore investigated this study by comparing renal phenotypes high-fat diet (HFD)-fed wild-type (WT) knockout (KO) mice. Male female WT mice on HFD 10 or 24 wk developed obesity, hyperinsulinemia, dysfunction manifested albuminuria glomerular injuries. these...
Postoperative outcome following deep brain stimulation (DBS) of the subthalamic nucleus is variable, particularly with respect to axial motor improvement. We hypothesized a genetic underpinning response surgical intervention, termed "surgicogenomics".We aimed identify variants associated clinical heterogeneity in DBS Parkinson's disease (PD) patients that could then be applied clinically target selection leading improved outcome.Retrospective data was extracted from 150 patient's charts....
We investigated the role of endoplasmic reticulum (ER) stress-regulated long noncoding RNA (lncRNA) lncMGC in pancreatic islets and pathology type 1 diabetes (T1D), as well potential lncMGC-based therapeutics.
Purpose: To evaluate the efficacy and safety of intravitreal injection (IVI) bevacizumab (IVB) versus aflibercept (IVA) in premature infants with type 1 prethreshold retinopathy prematurity (ROP) posterior Zone II. Methods: The study was a multicenter, historical cohort newborns diagnosed ROP II, treated IVB or IVA. Demographic features, complications, treatment outcomes were then compared between two groups. Results: Seventy-six patients received (the IVA group), 210 group). groups not...
The β-cyclodextrin coated magnetic nanoparticles were prepared by the surface modification of Fe3O4 using carboxymethyl-β-cyclodextrin. Prepared characterized X-ray diffraction analysis, transmission electron microscope, Fourier transform infrared spectroscopy, dynamic light scattering and vibrating sample magnetometer. modified have a narrow size distribution with mean diameter about 10 nm. They exhibit superparamagnetic properties at room temperature saturation magnetization 48 emu/g....
Rituximab, a chimeric monoclonal antibody against the CD20 B-cell antigen, is used to treat malignancies, rheumatoid arthritis, and autoimmune blistering diseases.Adverse events seen with rituximab include infusion reactions, infections, late or early-onset neutropenia.Specifically, neutropenia classified as grade III, an absolute neutrophil count (ANC) of 0.5-1.5 x 10 9 /L, IV, ANC less than 0.5 /L.In this case, we present bullous pemphigoid (BP) patient IV rituximabinduced safe...
Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown. We describe a novel AngII-induced lncRNA Alivec (Angiotensin II-induced VSMCs eliciting phenotype) implicated VSMC chondrogenesis. In rat VSMCs, and the nearby gene Acan, marker, were induced by growth factors AngII PDGF inflammatory cytokine TNF-α. co-regulated Acan through activation type1 receptor Sox9, master...