A5008236637- Cardiac Ischemia and Reperfusion
- Anesthesia and Neurotoxicity Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Arrest and Resuscitation
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Imaging and Diagnostics
- Bone Tissue Engineering Materials
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Silk-based biomaterials and applications
- High Altitude and Hypoxia
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Food Industry and Aquatic Biology
- Infectious Aortic and Vascular Conditions
- Periodontal Regeneration and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Health and Mental Health
- Philosophical and Historical Studies
- Philosophy, Science, and History
Kemerovo State University
2023-2024
Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences
2023
Tomsk National Research Medical Center
2017-2021
Russian Academy of Sciences
2017-2021
Institute of Cardiology
2019
Academy of Medical Sciences
2014-2015
The purpose of the review is analysis clinical and experimental data on etiology pathogenesis takotsubo syndrome (TS). TS characterized by contractile dysfunction, which usually affects apical region heart without obstruction coronary artery, moderate increase in myocardial necrosis markers, prolonged QTc interval (in 50% patients), sometimes elevation ST segment 19% N-Terminal Pro-B-Type Natriuretic Peptide level, microvascular spasm epicardial arteries 10% edema, life-threatening...
Aim To evaluate 5-year results of the HREVS (Hybrid REvascularization Versus Standarts) study.Material and methods The study included 155 consecutive patients with multivessel coronary artery disease who were randomized into 3 groups: bypass grafting (CABG) (n=50), hybrid revascularization (HCR) (n=52) percutaneous intervention (PCI) (n=53) according to consensus cardiology team on technical clinical feasibility each three strategies. primary endpoint was residual ischemia 12 months after...
Chronic continuous normobaric hypoxia (CNH) increases cardiac tolerance to ischemia/reperfusion injury in vivo and this effect is mediated via µ delta2 opioid receptors (ORs) activation. CNH has also been shown be cardioprotective isolated rat heart. In study, we hypothesize that of by activation ORs preservation mitochondrial function. Hearts from rats adapted (12 % oxygen) for 3 weeks were extracted, perfused the Langendorff mode subjected 45 min global ischemia 30 reperfusion....
One of the ways to reconstruct arterial wall is endarterectomy with a vascular patch. The use prostheses made from existing materials can lead complications need for reoperation. search new manufacture patches that have optimal compatibility vessel still relevant. Aim: To study dynamics and compare morphological features remodeling tissue-engineered silk fibroin (SF) biological xenopericardium (XP) flaps implanted into sheep carotid artery. Material Methods. Matrices 15% SF solution (n = 2)...
Summary Chronic continuous normobaric hypoxia ( CNH ) increases cardiac tolerance to acute ischaemia/reperfusion injury. The objective of this study was find out whether the cardioprotective effect mediated by opioid receptors is associated with preservation mitochondrial function. Rats were adapted (12% oxygen) for 3 weeks. Isolated perfused hearts subjected 45 min global ischaemia and 30 reperfusion; subgroups pretreated non‐selective receptor antagonist naloxone (300 nmol/L) 10 min....
The aim of the study was to make a vascular patch based on regenerated silk fibroin (SF) and its physical mechanical characteristics, biocompatibility matrix properties in comparison with polyhydroxybutyrate/valerate/polycaprolactone incorporated endothelial growth factor (PHBV/PCL/VEGF) commercial bovine xenopericardium (XP) flap experiments vitro.Materials Methods.Tissue-engineered matrices were produced by electrospinning.The surface structure, hemocompatibility (erythrocyte hemolysis,...
There is a growing need for synthetic small-diameter vascular grafts (<6 mm) bypass surgery since the majority of currently developed products have demonstrated unacceptable high frequency thrombosis in preclinical studies. The proprietary composite graft based on nonwoven polymer with anti-thrombogenic and anti-aneurysm effect functional activity aimed at stimulating formation neotissue implantation site. aim investigation to study surface morphology, physical mechanical properties...
Highlights Silk fibroin is resistant to early degradation, focal calcification, adsorbs albumin, and does not cause pronounced local systemic inflammation during subcutaneous implantation in rats, which comparable even superior properties bovine pericardium used vascular surgery. Aim . To study the hydrolytic degradation of silk (SF), evaluate a comparative aspect surface adsorption proteins by matrices from SF (BP), calcification biomaterials, as well their biocompatibility, dynamics...
Objective: to compare the remodeling features of polyurethane (PU) and bovine pericardium (BP) patches that have been implanted in a sheep carotid artery for 6 months. Materials methods. Synthetic matrices were fabricated from 12% PU solution chloroform by electrospinning on Nanon-01A machine (MECC, Japan). Biological made commercially produced (Kem-Periplas Neo, CJSC Neocor, Russia) used comparison. The as vascular into arteries (n = 3). Implantation period was Via ultrasound scan, patency...
The presented data show that tacotsubo syndrome (TS) is characterized by the absence of coronary artery obstruction, cardiac contractile dysfunction, apical ballooning, and heart failure, in some patients, ST-segment elevation prolongation QTc interval. Every tenth patient with TS develops ventricular arrhythmias. Most patients have elevated markers necrosis (troponin I, troponin Т, creatine kinase МВ (CK-МВ), which are considerably lower than acute myocardial infarction (AMI) elevation....
■ ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕЖДИСЦИПЛИНАРНЫЕ ТЕХНОЛОГИИ Актуальность.Сосудистые заплаты, применяемые при реконструктивных операциях, неоптимальны из-за различия в комплаентности материала и тканей стенки артерии.Основные недостатки: тромбозы, аневризмы рестенозы зоне анастомоза.Актуальна проблема оценки их функционирования эндотелизации на разных сроках имплантации.Одним из методов решения данной проблемы является оптическая когерентная томография (ОКТ).Цель -оценить результаты...
Highlights The article describes the features of remodeling polyurethane matrices during long-term implantation into vascular bed sheep. results indicate high biocompatibility and resistance to bioresorption. obtained data are significant for development medical products cardiovascular surgery, in particular, biodegradable prostheses. Abstract Aim. To evaluate a experiment on large animal model. Methods. Matrices made 12% solution chloroform were manufactured by electrospinning at Nanon-01A...
The objectives of this study were to investigate the role endogenous opioids in mediation stress-induced cardiomyopathy (SIC), and evaluate which opioid receptors regulate heart resistance immobilization stress. Wistar rats subjected 24 h Stress-induced injury was assessed by 99mTc-pyrophosphate accumulation heart. receptor (OR) antagonists (naltrexone, NxMB – naltrexone methyl bromide, MR 2266, ICI 174.864) agonists (DALDA, DAMGO, DSLET, U-50,488) administered intraperitoneally prior 12...
The humoral way of the realization cardioprotective effect remote ischemic preconditioning (RIPre) is demonstrated in various models ischemia-reperfusion: upper and lower extremities, liver, occlusion-reperfusion mesenteric renal arteries. As factors RIPre are considered following substances: hydrophobic peptides, opioid adenosine, prostanoids, endovanilloids, endocannabinoids, calcitonin gene-related peptide, leukotrienes, adrenomedullin, microRNA. Norepinephrine which also participate...
Цель обзора - анализ публикаций, посвященных кардиопротекторным эффектам мелатонина в условиях ишемии/реперфузии сердца эксперименте и клинике. Эксперименты анализируемых статьях проводились на крысах с коронароокклюзией реперфузией. Некоторые исследования выполнялись изолированном перфузируемом сердце крысы, которое подвергали ишемии/реперфузии. Для блокады рецепторов использовался Лузиндол. Клинические пациентах острым инфарктом миокарда подъёмом сегмента ST чрескожным коронарным...