A5072880181- Cardiac Ischemia and Reperfusion
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Cardiac Arrest and Resuscitation
- Neuropeptides and Animal Physiology
- Cardiac electrophysiology and arrhythmias
- Forensic Toxicology and Drug Analysis
- Cardiac Imaging and Diagnostics
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Anesthesia and Neurotoxicity Research
- Acute Myocardial Infarction Research
- Eicosanoids and Hypertension Pharmacology
- Heart Rate Variability and Autonomic Control
- Takotsubo Cardiomyopathy and Associated Phenomena
- Plant-based Medicinal Research
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Medicinal Plants and Bioactive Compounds
- Analytical Methods in Pharmaceuticals
- Diet, Metabolism, and Disease
- Atrial Fibrillation Management and Outcomes
- Renin-Angiotensin System Studies
Russian Academy of Sciences
2008-2024
Tomsk National Research Medical Center
2002-2024
Institute of Cardiology
2002-2019
National Research Tomsk State University
2015
Tomsk Polytechnic University
2015
Academy of Medical Sciences
1996-2014
Tomsk State Pedagogical University
2002-2010
Air Force Medical University
2010
Hebrew University of Jerusalem
2010
University of Kentucky
2010
Abstract Background The high mortality rate of patients with acute myocardial infarction (AMI) remains the most pressing issue modern cardiology. Over past 10 years, there has been no significant reduction in among AMI. It is quite obvious that an urgent need to develop fundamentally new drugs for treatment Angiotensin 1–7 some promise this regard. Objective objective article analysis published data on cardioprotective properties angiotensin 1–7. Methods PubMed, Scopus, Science Direct, and...
The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon, also known as microvascular obstruction (MVO). However, studies performed isolated perfused hearts subjected to ischemia/reperfusion (I/R) do not suggest involvement microembolization microthrombi this phenomenon. intracoronary administration alteplase has been found have no effect on occurrence MVO patients with acute myocardial infarction. Consequently, major events...
Abstract Objectives: This study was conducted to test the hypothesis that opioid receptor (OR)‐mediated cardioprotection is agonist specific when administered prior coronary artery occlusion and reperfusion in a rat model. Methods: Anesthetized open‐chest male Wistar rats were subjected 45 minutes of left 2 hours reperfusion. Opioid agonists infused 15 occlusion. Two control groups opioid‐treated studied. Controls with either saline alone ( n = 16) or dimethyl sulfoxide plus...
Ischemic-reperfusion injuries of organs underlie such common pathologies as ischemic stroke and myocardial infarction are the cause death disability in population. In addition, lung damage is observed pulmonary embolism. Advances transplantology, well widespread use coronary artery bypass grafting, raise problem ischemia reperfusion during these manipulations. Progress made over past three decades treatment acute (AMI) has slowed recent years. Since patients with AMI admitted to hospital...
Background . The high mortality rate among patients with acute myocardial infarction (AMI) is an important problem of modern cardiology. In recent years, there has not been a significant decrease in AMI. Drugs used to treat AMI are effective enough, so need develop fundamentally new drugs that can significantly increase the heart’s tolerance ischemia/reperfusion (I/R). Angiotensin 1-7 peptide, which cardiac I/R by activating Mas receptor tissue, could become prototype such drugs. following...
Abstract Objectives The objective of this study was to investigate the role peripheral μ, δ 1 , 2 and nociceptin opioid receptors agonists in regulation cardiac tolerance arrhythmogenic effect ischemia/reperfusion rats. Methods Anesthetized open‐chest male Wistar rats were subjected either 45 minutes left coronary artery occlusion (phase 1a 10 phase 2b 35 minutes) hours reperfusion Experiment or ischemia 2. In 1, saline vehicle controls mu‐specific opioids dermorphin‐H (Derm‐H) ([ d ‐Ala2, N...