A5075284713- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Anesthesia and Neurotoxicity Research
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Mechanical Circulatory Support Devices
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Renin-Angiotensin System Studies
- Cancer, Lipids, and Metabolism
- Metabolism, Diabetes, and Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Cell death mechanisms and regulation
- Neuroscience of respiration and sleep
Tomsk National Research Medical Center
2021-2024
Russian Academy of Sciences
2022-2024
Institute of Cardiology
2022
Catecholamines and β-adrenergic receptors (β-ARs) play an important role in the regulation of cardiac tolerance to impact ischemia reperfusion. This systematic review analyzed molecular mechanisms cardioprotective activity β-AR ligands.
Abstract Background The high mortality rate of patients with acute myocardial infarction (AMI) remains the most pressing issue modern cardiology. Over past 10 years, there has been no significant reduction in among AMI. It is quite obvious that an urgent need to develop fundamentally new drugs for treatment Angiotensin 1–7 some promise this regard. Objective objective article analysis published data on cardioprotective properties angiotensin 1–7. Methods PubMed, Scopus, Science Direct, and...
The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon, also known as microvascular obstruction (MVO). However, studies performed isolated perfused hearts subjected to ischemia/reperfusion (I/R) do not suggest involvement microembolization microthrombi this phenomenon. intracoronary administration alteplase has been found have no effect on occurrence MVO patients with acute myocardial infarction. Consequently, major events...
The acute myocardial infarction (AMI) and sudden cardiac death (SCD), both associated with ischemia, are one of the leading causes adult in economically developed countries. development new approaches for treatment prevention AMI SCD remains highest priority medicine. A study on cardiovascular effects chronic hypoxia (CH) may contribute to these methods. Chronic exerts positive adverse effects. infarct-reducing, vasoprotective, antiarrhythmic effects, which can lead improvement contractility...
Microvascular obstruction (MVO) of coronary arteries increases the mortality rate and major adverse cardiac events in patients with acute myocardial infarction (AMI) percutaneous intervention (PCI). According to preliminary data platelets, inflammation, Ca2+ overload, neuropeptide Y, endothelin-1 could be involved pathogenesis MVO. Many questions related MVO remain unanswered. The role endothelial cell damage formation AMI PCI is unknown. It unclear whether nitric oxide (NO) production...
Background . It is known that the protective effect of adaptation and conditioning influence weakened in animals with metabolic syndrome. Metabolic syndrome may be basis for failure cardioprotection clinical settings. The aim study To identify relationship between disorder carbohydrate lipid metabolism a decrease effectiveness infarct-limiting moderate chronic normobaric hypoxia; to check possibility correcting reduced by normalizing metabolism. Methods included 64 Wistar rats. was induced...
Abstract Background Currently, there is no effective therapy for takotsubo syndrome (stress‐induced cardiac injury in humans) the clinics. It has previously been shown that β 2 ‐adrenergic receptor (β ‐AR) agonist formoterol reduces cardiomyocyte experimental syndrome. Objectives The aim of this study was to investigate whether prevents apoptosis and necrosis cardiomyocytes endothelial cells stress‐induced cardiomyopathy. Methods Stress‐induced induced by immobilization rats 2, 6, 24 hours....
Age and diabetes are a risk factor for arterial hypertension. In the presented work, morphological basis of an increase in blood pressure under influence high-carbohydrate high-fat diet old rats was investigated. It determined connective tissue growth levels changes aortic wall. A study carried out male Wistar weighing 350–400 g, 140 day 530-620 540 at end research. All procedures conformed to Directive 2010/63/EU European Parliament FASEB Statement Principles use Animals Research Education....
Background. It is known that adaptation to chronic continuous hypoxia leads a pronounced cardioprotective effect. The efficiency of acute reduced in metabolic syndrome. However, the effectiveness myocardial infarct size-limiting effect syndrome remains an understudied fact. aim. To study development rats with Materials and methods. was carried out on 43 Wistar rats. Adaptation animals performed during 21 days hypoxic chamber (12 % O2, 0.3 CO 2 ). Metabolic modeled by keeping...
It is known that moderate chronic hypoxia leads to an increase in myocardial resistance ischemia-reperfusion. The receptor mechanisms of this phenomenon are poorly understood. aim the study was identify participation adenosine and cannabinoid receptors infarction-limiting effect normobaric hypoxia. experiments were carried out on male Wistar rats weighing 250–300 g. All procedures conformed Directive 2010/63/EU European Parliament FASEB Statement Principles for use Animals Research...